A New Bioactive Sesterterpene and Antiplasmodial Alkaloids from the Marine Sponge <i>Hyrtios</i> cf. <i>erecta</i>

Kirsch, G.; Kong, Guimei; Wright, Anthony D.; Kaminsky, Ronald

doi:10.1021/np990555b

Cited by 101 publications

(90 citation statements)

References 27 publications

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“…35 Several alkaloids isolated from marine organisms such as sponges, ascidians and tunicates have been evaluated for their antitrypanosomal activity. 38 Two pyridoacridone alkaloids, ascididemin 37 and 2-bromoascididemin 38 are other marine metabolites. Compound 37 is a pentacyclic DNA intercalating agent with marked cytotoxic activities.…”

Section: Alkaloidsmentioning

confidence: 99%

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

et al. 2004

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This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp., T. congolense and T. vivax) isolated from natural sources and is organized according to the structure of the metabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from the mid-1980s up to June 2003 is reviewed and 89 references are cited. Sara Hoet was born in

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Section: Alkaloidsmentioning

confidence: 99%

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

et al. 2004

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“…In favour of this hypothesis is the finding of both types of metabolites in a sample of Hyrtios cf. erecta from Fiji (Kirsch et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Chemical and biological aspects of sponge secondary metabolites

Braekman¹,

Daloze²

2004

Phytochem Rev

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Sponge secondary metabolites have been investigated to find potential lead compounds for the development of commercially interesting products. During the Camellia project entitled 'Environmentally compatible antifouling coatings for the protection of ships, water systems, fish cages and other immersed structures against aquatic growth,' several analogues of terpenes containing isocyano, thioisocyano, thiocyano and formamide functionalities were synthesized and evaluated for their antifouling activity against the settlement of the barnacle Balanus amphitrite. The best activities were obtained with N-formylated alkylamines the length of the carbon chain of which is comprised between C-11 and C-14. In the aromatic series, the isocyano derivatives showed high antifouling activities. But they were too toxic against many microorganisms to be incorporated in paint formulations. During the Symbiosponge project entitled 'Biology of sponge natural products' the methanolic extract of about 230 sponges were submitted to bioassays guided fractionation to isolate bioactive compounds. Several cytostatic sesquiterpene quinones and tryptamine-derived alkaloids were isolated from 4 sponges of the genus Hyrtios. A new 4-sphingenine analogue and a novel polyacetylenic derivative were found to be responsible for the bioactivities of the methanolic extracts of Haliclona vansoesti and Callyspongia pseudoreticulata, respectively.

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“…The CH 2 Cl 2 extract of a Fijian collection of the sponge Hyrtios cf. erecta inhibited p56 lck TK activity by 80% at 100 μg/mL [283]. Upon further investigation three known compounds with extremely weak inhibitory activity were isolated, Fig.…”

Section: Signal Transduction Tyrosine-specific Protein Kinasesmentioning

confidence: 92%

Mechanism Targeted Discovery of Antitumor Marine Natural Products

Nagle¹,

Zhou²,

Mora³

et al. 2004

Current Medicinal Chemistry

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Antitumor drug discovery programs aim to identify chemical entities for use in the treatment of cancer. Many strategies have been used to achieve this objective. Natural products have always played a major role in anticancer medicine and the unique metabolites produced by marine organisms have increasingly become major players in antitumor drug discovery. Rapid advances have occurred in the understanding of tumor biology and molecular medicine. New insights into mechanisms responsible for neoplastic disease are significantly changing the general philosophical approach towards cancer treatment. Recently identified molecular targets have created exciting new means for disrupting tumor-specific cell signaling, cell division, energy metabolism, gene expression, drug resistance, and blood supply. Such tumor-specific treatments could someday decrease our reliance on traditional cytotoxicity-based chemotherapy and provide new less toxic treatment options with significantly fewer side effects. Novel molecular targets and state-of-the-art molecular mechanism-based screening methods have revitalized antitumor research and these changes are becoming an ever-increasing component of modern antitumor marine natural products research. This review describes marine natural products identified using tumor-specific mechanism-based assays for regulators of angiogenesis, apoptosis, cell cycle, macromolecule synthesis, mitochondrial respiration, mitosis, multidrug efflux, and signal transduction. Special emphasis is placed on natural products directly discovered using molecular mechanism-based screening.

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A New Bioactive Sesterterpene and Antiplasmodial Alkaloids from the Marine Sponge Hyrtios cf. erecta

Cited by 101 publications

References 27 publications

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

Chemical and biological aspects of sponge secondary metabolites

Mechanism Targeted Discovery of Antitumor Marine Natural Products

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