A new bioactive material which transforms in situ into hydroxyapatite

Aza, Piedad N. De; Guitián, Francisco; Aza, S. De

doi:10.1016/s1359-6454(98)80038-4

Cited by 41 publications

(30 citation statements)

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“…A new approach to overcoming this problem was proposed by De Aza et al [101][102][103][104][105][106].This is based on designing dense bioactive ceramic materials with the ability to develop an in situ porous hydroxyapatite-like (HA) structure when they are implanted into a living body. The material was composed of …”

Section: Wollastonite-tricalcium Phosphate (Bioeutectic ® )mentioning

confidence: 99%

Crystalline Bioceramic Materials

Aza

2006

ChemInform

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A strong interest in the use of ceramics for biomedical engineering applications developed in the late 1960´s. Used initially as alternatives to metallic materials in order to increase the biocompatibility of implants, bioceramics have become a diverse class of biomaterials, presently including three basic types: relatively bioinert ceramics; bioactive or surface reactive bioceramics and bioresorbable ceramics. This review will only refer to bioceramics "sensus stricto", it is to say, those ceramic materials constituted for nonmetallic inorganic compounds, crystallines and consolidated by thermal treatments of powders to high temperatures. Leaving bioglasses, glass-ceramics and biocements apart, since, although all of them are obtained by thermal treatments to high temperatures, the first are amorphous, the second are obtained by desvitrification of a glass and in them vitreous phase normally prevails on the crystalline phases and the third are consolidated by means of a hydraulic or chemical reaction to room temperature. A review of the composition, physiochemical properties and biological behaviour of the principal types of crystalline bioceramics is given, based on the literature data and on the own experience of the authors. Key words: alumina, zirconia, zirconia-toughened alumina, graphite, hydroxyapatite, bioactive silicates, bioeutectic � , tricalcium phosphate Materiales biocerámicos cristalinosA finales de los años sesenta se despertó un gran interés por el uso de los materiales cerámicos para aplicaciones biomédicas. Inicialmente utilizados como una alternativa a los materiales metálicos, con el propósito de incrementar la biocompatibilidad de los implantes, las biocerámicas se han convertido en una clase diversa de biomateriales, incluyendo actualmente tres tipos: cerámicas cuasi inertes; cerámicas bioactivas o reactivas superficialmente y cerámicas reabsorbibles o biodegradables. En la presente revisión se hace referencia a las biocerámicas en sentido estricto, es decir, a aquellos materiales constitutitos por compuestos inorgánicos no metálicos, cristalinos y consolidados mediante tratamientos térmicos a altas temperaturas. Dejando aparte los biovidrios, los vitrocerámicos y los biocementos, puesto que, si bien todos ellos son obtenidos por tratamiento térmicos a altas temperaturas, los primeros son amorfos, los segundos son obtenidos por desvitrificación de un vidrio, prevaleciendo normalmente la fase vítrea sobre las fases cristalinas, y los terceros son consolidados mediante una reacción química o hidráulica a temperatura ambiente. Así pues, teniendo en cuenta la abundante bibliografía sobre el tema y la experiencia propia de los autores, se presenta una revisión de la composición, propiedades fisicoquímicas, aplicaciones y comportamiento biológico de los principales tipos de biocerámicas cristalinas.

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Section: Wollastonite-tricalcium Phosphate (Bioeutectic ® )mentioning

confidence: 99%

Crystalline Bioceramic Materials

Aza

2006

ChemInform

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“…In a previous study, a new ceramic material called Bioeutectic 1 (a composition of 60%CS/40%TCP), prepared by slow solidification through the eutectic temperature region of the wollastonite-tricalcium phosphate system, was found to be reactive in SBF fluid and human parotid saliva. [13][14][15] Huang et al also prepared the wollastonite-tricalcium composites with a composition of 60 wt % W and 40 wt % TCP. 16 However, they only studied the bioactivity in SBF, no further studies on this composite were reported.…”

Section: Introductionmentioning

confidence: 99%

β‐CaSiO₃/β‐Ca₃(PO₄)₂ composite materials for hard tissue repair: In vitro studies

Lin

Chang

et al. 2007

J Biomedical Materials Res

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In this study, a series of beta-CaSiO(3) (CS)/beta-Ca(3)(PO(4))(2) (TCP) composites with different ratios were prepared to produce new bioactive and biodegradable biomaterials for potential bone repair. The mechanical properties of CS-TCP composites increased steadily with the increase of TCP amounts in composites. Formation of bone-like apatite on a range of CS-TCP composites with CS weight percentage ranging from 0 to 100 has been investigated in simulated body fluid (SBF). The presence of bone-like apatite layer on the composite surface after soaking in SBF was demonstrated by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and fourier transform infrared reflection spectroscopy (FTIR). The results showed that the apatite formation ability of the CS-TCP composite was enhanced with increasing CS content in the composites. For composites with more than 50% CS contents, the samples were completely covered by a layer of dense bone-like apatite just after 3 days immersion. Dissolution tests in Tris-HCl buffer solution showed obvious differences with different CS contents in composites. The dissolution rate increased with the increase of CS content, which suggested that the solubility of biphasic composites could be tailored by adjusting the initial CS/TCP ratio. In vitro cell experiments showed that higher content of CS phase in composites promoted cell proliferation and differentiation. When the CS amount in the composite increased to 50%, the proliferation rate and ALP activities of osteoblast-like cells showed significant difference compared with pure TCP (p < 0.05). Results of the study suggested that the CS-TCP composites with more than 50% CS content might be promising bone repair materials.

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“…As the surface Ap layer becomes thicker the inner reaction is slowed down until it finally stops (31)(32)(33)(34). Bioeutectic ® reacted in a similar way when SBF was substituted by human parotid saliva but in lesser extension R. GARCíA-CARRODEGUAS (31)).…”

Section: Eqmentioning

confidence: 98%

“…Such a material should be composed of at least two phases, one bioactive and the other resorbable (30)(31)(32)(33)(34). S. De Aza knew very well the thermodynamic and kinetic rules of binary systems with and eutectic invariant point.…”

Section: Bioeutectic ® : the First Bulk-bioactive Materialsmentioning

confidence: 99%

“…De Aza et al studied the system and found the exact eutectic composition and temperature are CaSiO 3 60 wt.-%, Ca 3 (PO 4 ) 2 40 wt.-%, and 1402 ± 3 ºC, respectively (37). Then they prepared a ceramic material with a microstructure formed by rounded colonies (rosettes) by slow solidification of a melt with the eutectic composition, under a radial gradient of heat extraction (31)(32)(33)(34)38). Figure 3 …”

Section: Bioeutectic ® : the First Bulk-bioactive Materialsmentioning

confidence: 99%

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Las principales contribuciones de Salvador de Aza a las Biocerámicas

Carrodeaguas¹,

Aza²

2011

Bol. Soc. Esp. Ceram. Vidr.

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A full compilation of Salvador De Aza works on biomedical materials is a huge task beyond the aim of this paper; instead it is intended to stand out De Aza's thoughts and leadership in the field of Bioceramics and to pay tribute to his memory. The most outstanding works of Professor Salvador De Aza related to Bioceramics, from the point of view of the authors, are commented and discussed. Topics the authors chose among many other De Aza's works on biomedical materials are: The prediction and demonstration of bioactivity in pseudo-wollastonite ceramics; the use of phase diagrams to design bulk-bioactive ceramics with eutectic microstructures; the relationship between bioactivity and microstructure in ceramic biomaterials; and the studies on the polymorphic phase transitions in tricalcium phosphate. Keywords: Bioceramics, Bioeutectic, Wollastonite, Pseudowollastonite, Tricalcium Phosphate, Microstructure, Polymorphic Transformation Las principales contribuciones de Salvador de Aza a las BiocerámicasUna recopilación completa de la obra de Salvador De Aza sobre materiales biomédicos es una tarea enorme más allá del objetivo de este trabajo, que está destinado a destacar sus enfoques y liderazgo en el campo de las Biocerámicas y rendir merecido tributo a su memoria. Para ello se discuten y comentan aquellos trabajos del Profesor Salvador De Aza sobre Biocerámicas que a juicio de los autores resultan más sobresalientes. Entre muchos otros trabajos de De Aza sobre materiales biomédicos, los autores han elegido los siguientes tópicos: la predicción y demostración de la bioactividad de las cerámicas de pseudo-wollastonita; el uso de diagramas de fase para el diseño de materiales bioactivos en masa con microestructura eutéctica; y sus estudios sobre la transición polimorfica de fases en el fosfato tricálcico.

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A new bioactive material which transforms in situ into hydroxyapatite

Cited by 41 publications

References 10 publications

Crystalline Bioceramic Materials

Crystalline Bioceramic Materials

β‐CaSiO₃/β‐Ca₃(PO₄)₂ composite materials for hard tissue repair: In vitro studies

Las principales contribuciones de Salvador de Aza a las Biocerámicas

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A new bioactive material which transforms in situ into hydroxyapatite

Cited by 41 publications

References 10 publications

Crystalline Bioceramic Materials

Crystalline Bioceramic Materials

β‐CaSiO3/β‐Ca3(PO4)2 composite materials for hard tissue repair: In vitro studies

Las principales contribuciones de Salvador de Aza a las Biocerámicas

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β‐CaSiO₃/β‐Ca₃(PO₄)₂ composite materials for hard tissue repair: In vitro studies