A new bicyclic sesquiterpene from the marine sponge associated fungus Emericellopsis minima

Pinheiro, Ângela; Dethoup, Tida; Bessa, Júlia; Silva, Artur M. S.; Kijjoa, Anake

doi:10.1016/j.phytol.2011.10.002

Cited by 26 publications

(13 citation statements)

References 6 publications

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“…4-Hydroxymellein ( 2 ) has been isolated from many fungi such as Ascochyta sp. [ 16 ], Botryosphaeria mamane [ 17 ], Botryosphaeria obtusa [ 9 , 18 ], Botryosphaeria rhodina [ 19 ], Cercospora taiwanensis [ 20 ], Dinemasporium strigosum [ 21 ], Emericellopsis minima [ 22 ], Lasiodiplodia theobromae [ 23 ], Meliotus dentatus [ 24 ], Penicillium sp. [ 25 ], Seimatosporium sp.…”

Section: Resultsmentioning

confidence: 99%

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

et al. 2012

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The endophytic fungus Hyalodendriella sp. Ponipodef12 was isolated from the hybrid ‘Neva’ of Populus deltoides Marsh × P. nigra L. In this study, four benzopyranones were isolated from the ethyl acetate extract of Hyalodendriella sp. Ponipodef12, and identified as palmariol B (1), 4-hydroxymellein (2), alternariol 9-methyl ether (3), and botrallin (4) by means of physicochemical and spectroscopic analysis. All the compounds were evaluated for their antibacterial, antifungal, antinematodal and acetylcholinesterase inhibitory activities. 4-Hydroxymellein (2) exhibited stronger antibacterial activity than the other compounds. Palmariol B (1) showed stronger antimicrobial, antinematodal and acetylcholinesterase inhibitory activities than alternariol 9-methyl ether (3) which indicated that the chlorine substitution at position 2 may contribute to its bioactivity. The results indicate the potential of this endophytic fungus as a source of bioactive benzopyranones.

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Section: Resultsmentioning

confidence: 99%

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

et al. 2012

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“…214 Both helicascolide C and helicascolide A, 215 previously isolated from the fungus Helicascus kanaloanus, have been synthesised by acid catalysed acetonide deprotection, followed by a one-pot intramolecular lactonisation as the key step. 216 The endophyte Emericellopsis minima (sponge Hyrtios erecta, Similan Islands, Thailand) was the source of the sesquiterpene 221, 217 while an Epicoccum sp. (sponge Callyspongia sp., Sanya, China) provided the pyronepolyene C-glucoside iso-D8646-2-6 222 along with the known isomer D8646-2-6.…”

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2014

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This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…Compound 35 did not have a cytotoxic effect against MRC-5 and AGS cell lines[91]. Moreover, 6 possessed no cytotoxic capacity against NCIH460, MCF-7, and A375-C5 cell lines using the protein binding dye SRB method[92]. The cytotoxic abilities against A549, NB4, MCF7, SHSY5Y, and PC3 tumor cell lines of 38, 52, 53, 127, 137, 251, and 301 were tested [93].…”

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confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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A new bicyclic sesquiterpene from the marine sponge associated fungus Emericellopsis minima

Cited by 26 publications

References 6 publications

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

Benzopyranones from the Endophytic Fungus Hyalodendriella sp. Ponipodef12 and Their Bioactivities

Marine natural products

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

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