A new Bi₂MoO₆ nano-tremella-based electrochemical immunosensor for the sensitive detection of a carcinoembryonic antigen

Abstract

Novel Bi2MoO6 nanohybrids with a tremella-like structure modified with gold nanoparticles were used to fabricate an electrochemical immunosensing platform of CEA.

A frogspawn-like Ag@C core–shell structure for an ultrasensitive label-free electrochemical immunosensing of carcinoembryonic antigen in blood plasma

“…The regression equations of both anodic ( I pa ) and cathodic ( I pc ) peaks were I pa = 199.09 v 1/2 + 25.13 and I pc = −174.46 v 1/2 − 30.35, respectively, indicating that the redox reaction was controlled by diffusion. 35 Generally, the electro-active surface area of the modified electrode can be calculated according to the Randles–Sevcik equation I = 2.69 × 105 A × D 1/2 n 3/2 v 1/2 C , 36 where n is the number of electrons transferred in the redox reaction ( n = 1), A is the electrode electrochemical active area, D is the diffusion coefficient (6.70 × 10 −6 cm 2 s −1 , 25 °C), C is the concentration of the reactant (5 × 10 −3 mol L −1 Fe(CN) 6 3−/4− ), v is the scan rate (V s −1 ) and I is the peak current (μA) of the CV measurement. Here, the electro-active surface area of Ag@C NFSs/GCE was calculated to be 0.0827 cm 2 , 1.17 times higher than the initial surface area of the bare GCE ( d = 3 mm, 0.0707 cm 2 ), suggesting that Ag@C NFSs would greatly enlarge the surface area of the modified electrode, leading to remarkably accelerated electron transfer on the electrode surface.…”

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

“…The developed immunosensor showed good repeatability and excellent selectivity with potentials in clinical usage. Wang and his group [43] reported an EC immunosensor developed by using bismuth oxide doped with molybdenum using a one-pot synthesis method and then modified with NH 2 group and AuNPs to form Au@Bi 2 MoO 6 nanotubes with a tremella-like crystal structure (Figure 3). This was used as the electroactive material to coat the glassy carbon electrode via the drop-drying method.…”

Bismuth Molybdate/Graphene Nanocomposite for Electrochemical Detection of Mercury

“…In particular, bismuth molybdate (BiM) has been selected as a promising electrode material due to its ample active sites, tunable bandgap (2.5–2.8 eV), good surface area, low toxicity, high redox activities, cycling stability, and variable valence states. − There are three different types of BiM phases, such as α-Bi 2 Mo 3 O 12 , β-Bi 2 Mo 2 O 9, and γ-Bi 2 MoO 6 , with variable physicochemical properties . Among these phases, γ-Bi 2 MoO 6 has gained special attention and is widely studied for various electrochemical applications .…”