A new behavioral test for antidepressant drugs

Nomura, Soichiro; Shimizu, Jun; Kinjo, Masatate; Kametani, Hideki; Nakazawa, Tsuneyuki

doi:10.1016/0014-2999(82)90248-5

Cited by 100 publications

(39 citation statements)

References 1 publication

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“…The number of rotations of the wheel, recorded automatically, is considered an index of attempts to escape. This procedure, adopted by other authors (Galina and Kastin 1985;Kastin et al 1984), gives different results from FST (see Nomura et al 1982b), and therefore data obtained by this procedure were not included in this review. As pointed out previously, due to the great variability in animal response, larger groups of mice (10 20) were used as compared to rats (8-10).…”

Section: Methodological Considerationsmentioning

confidence: 99%

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988

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Section: Methodological Considerationsmentioning

confidence: 99%

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988

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“…The relevance of using the FST for this new ways of research needs clinical correlations to validate also the FST for this utilization. The development of clinically effective antidepressant Nomura et al (1982) drugs with novel mechanisms should give answers to this question. Another point is the utilization of the FST for genetically modified animals that is applicable to study mechanisms of action of antidepressant on the test.…”

Section: Construct Validitymentioning

confidence: 98%

Forced swimming test in mice: a review of antidepressant activity

Petit-Demoulière¹,

Chenu²,

Bourin³

2004

Psychopharmacology

839

531

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“…The antidepressant action of the astmgal preparations was evaluated by measuring the number of turns of a wheel rotated by rats in a swimming pool [4], the test being modified as described in [5]. The effect of the plant preparation was compared to the action of amitriptylin (antidepressant) and caffeine (psychostimulator).…”

Section: Experimental Partmentioning

confidence: 99%

Psychotropic properties of mongolian astragal

Молодавкин

Aldarmaa²,

Воронина³

et al. 1998

Pharm Chem J

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Tranquilizers of the benzodiazepine group, albeit widely used in clinical practice, are known to exhibit a number of side effects (myorelaxant, sedative, and amnesic) and have a risk of inducing a drug dependence. For this reason, there is continuing search for alternative, more safe tranquilizers producing "soft" anxiolytic action. In particular, some medicinal plants may serve as such tranquilizers. These preparations are usually administered as sedative agents [1], although the question as to whether they also possess a tranquilizer and antidepressant activity requires additional investigation.The purpose of this work was to study the anxiolytic and antidepressant properties and possible side effects of some medicinal herbs occurring in Russia and Mongolia.In this park we have studied the effects of astragalus mongolensis (fabaceous family), allium odoratum (liliaceae family), paeonia anomala (Ranunculaceae family), and patrinia montana (valeriana family). The maximum activity was observed for the plants of astragal; therefore, preparations of this plant were studied in more detail. EXPERIMENTAL PARTExperiments were performed on a group of white mongrel male rats weighing 200 -250 g.The anxiolytic activity of the medicinal plant preparations was studied using a model of conflict situation (drinking motivation versus electroshock pain irritation) and evaluated by monitoring the number of penalized water takes from a dish at an electric current strength of 0.5 or 1 mA [2,3]. The reference drug was the well-known tranquilizer phenazepam.The antidepressant action of the astmgal preparations was evaluated by measuring the number of turns of a wheel rotated by rats in a swimming pool [4], the test being modified as described in [5]. The effect of the plant preparation was compared to the action of amitriptylin (antidepressant) and caffeine (psychostimulator).

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A new behavioral test for antidepressant drugs

Cited by 100 publications

References 1 publication

Is the forced swimming test a suitable model for revealing antidepressant activity?

Is the forced swimming test a suitable model for revealing antidepressant activity?

Forced swimming test in mice: a review of antidepressant activity

Psychotropic properties of mongolian astragal

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