A New Avenue to the Synthesis of Symmetrically Substituted Pyridines Catalyzed by Magnetic Nano–Fe₃O₄: Methyl Arenes as Sustainable Surrogates of Aryl Aldehydes

Abstract

A straightforward strategy has designed for the efficient synthesis of 2,4,6-triarylpyridinesvia a three component reaction of acetophenone, methyl arenes and ammonium acetate. The total transformation is successfully achieved using a magnetic nano-Fe 3 O 4 . The method developed is sustainable, using low cost feed stocks, operationally simple, and provide good to excellent yields.

Magnetically recoverable catalysts for the preparation of pyridine derivatives: an overview

“…Gajaganti and his co-workers utilised nano-Fe 3 O 4 as a catalyst in the synthesis of 2,4,6-tri-arylpyridines 71 via a three-component reaction of acetophenone derivatives 22, methyl arenes 70, and ammonium acetate 10 ( Scheme 25 ). 52 …”

A New Avenue to One-Pot Four-Component Synthesis of Spiro[indoline-3,4′-quinoline] Derivatives Using DABCO as a Green Catalyst

“…The philosopher's stone is catalysis in chemical industries, which acts as a driving force for chemical reactions. 1,2 Catalysts play an important role in forming an extensive range of value-added products crucial to humans. A coherent and scientific design of proficient catalysts is vital to improving the performance of chemical reactions.…”