A New Automated Computerized Analyzing System Simplifies Readings and Reduces the Variability in Ultrasound Measurement of Intima-Media Thickness

Wendelhag, Inger; Liang, Qi; Gustavsson, Tomas; Wikstrand, John

doi:10.1161/01.str.28.11.2195

Cited by 334 publications

(305 citation statements)

References 16 publications

Supporting

Mentioning

282

Contrasting

Unclassified

Order By: Relevance

“…Following previously prescribed protocols, 25 these segments were imaged and measured by the same observer. The images were digitized and imported into the Artery Measurement Systems automated software 26,27 for dedicated analysis of intima-media thickness. A maximal 10-mm segment with good image quality was chosen for analysis.…”

Section: Cardiovascular Measurementsmentioning

confidence: 99%

Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA study

et al. 2012

View full text Add to dashboard Cite

Hypertension and obesity are serious health burdens in sub-Saharan Africa. Urbanized Africans seem to be more susceptible to the development of these diseases than Caucasians. Current research suggests that leptin may be an important contributor to the development of hypertension and atherosclerosis. The aim of this study was to investigate leptin levels and their associations with cardiovascular function in urbanized Africans and Caucasians. Serum leptin, ambulatory blood pressure and carotid intima-media thickness were measured, and the cross-sectional wall area (CSWA) was calculated. The results showed that Africans had higher leptin levels (Po0.001), ambulatory blood pressure (Po0.001), carotid intima-media thickness (Po0.01) and CSWA (Po0.01) than Caucasians. As we found no interaction between ethnicity and gender for the association between leptin and the cardiovascular variables, we focused mainly on the total group of Africans and Caucasians. In single, partial and multiple regression analyses, positive associations of ambulatory systolic blood pressure (b ¼ 0.256; Po0.001), diastolic blood pressure (b ¼ 0.143; P ¼ 0.012), pulse pressure (b ¼ 0.327; Po0.001) and CSWA (b ¼ 0.107; P ¼ 0.038) with leptin were observed. Even after adjusting for body mass index (BMI), the association between CSWA (b ¼ 0.107; P ¼ 0.038) and leptin remained. Our findings therefore suggest that leptin may contribute to the development of atherosclerosis, independent of BMI.

show abstract

Section: Cardiovascular Measurementsmentioning

confidence: 99%

Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA study

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The images were digitized and imported into the AMS automated software for dedicated analyses of CIMT. 34,35 A maximal 10 mm segment with good image quality was chosen for analysis. The program automatically identifies the borders of the intima-media of the near and far wall, and the inner diameter of the vessel and calculates the CIMT and diameter from around 100 discrete measurements through the 10 mm segment.…”

Section: Measurements Of Sub-clinical Target Organ Damagementioning

confidence: 99%

Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: The SABPA Study

Schutte

Huisman

et al. 2011

Hypertens Res

View full text Add to dashboard Cite

The prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant risk for cardiovascular disease. We therefore compared 24-h BP variability with various traditional and advanced BP measurements, regarding their association with sub-clinical organ damage in black and white South Africans. The study included 409 African and Caucasian teachers aged 25-60 yrs. We measured office BP, 1-min continuous (finger) BP, ambulatory BP, BP reactivity and determined weighted 24-h BP variability. Albumin-to-creatinine ratio, Cornell product and carotid cross-sectional wall area (CSWA) were measures of organ damage. Africans had higher 24-h BP, BP variability, BP reactivity and sub-clinical organ damage (Po0.001). Correlations of BP variability with organ damage were overall weak when compared with other BP measurements. In normotensive groups, we found an independent association of 24-h systolic BP (SBP) variability with Cornell product only in Africans (r¼0.37; P¼0.01), confirmed in multiple regression models, with 24-h SBP included in the model. Only in hypertensive Caucasians, a significant correlation between CSWA and 24-h SBP variability was evident (r¼0.30; P¼0.01), although CSWA indicated stronger correlations with office or 24-h SBP than 24-h SBP variability. To conclude, 24-h SBP variability could potentially be an effective measure for the early detection of normotensive Africans at increased risk for the development of cardiovascular complications. Its usefulness based on associations with target organ damage in hypertensive groups seems to be less than traditional office or 24-h BP measurements. Hypertension Research (2011Research ( ) 34, 1127Research ( -1134 doi:10.1038/hr.2011; published online 28 July 2011Keywords: albumin-to-creatinine ratio; ethnicity; intima-media thickness; left ventricular hypertrophy INTRODUCTIONThe prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention in the literature. [1][2][3][4][5][6][7][8][9][10] Where some papers emphasize the importance of BP variability in prediction of risk of vascular events, 1,2,6,9 others question its prediction of cardiovascular outcome. 4,5,10 Despite this upsurge of recent papers, consistent evidence over the past three decades lends support that both target organ damage and the rate of cardiovascular events of hypertensive patients are significantly and independently related to the degree of BP variability. [11][12][13][14][15] A limitation of many of these papers is that either BP variability alone was investigated, or various measures of BP variability (such as s.d. of 24-h BP, average real variability index 16 and weighted 24-h BP s.d. 17 ) were being compared, regarding the strength of their association with target organ damage.The question therefore arises how BP variability would benchmark against a comprehensive range of both traditional and advanced

show abstract

“…Measurements were done in the far wall according to the leading edge principle using a specially designed, computer-assisted image analyzing system based on automated detection of the echo structures but with the option for manual corrections of the operator [23].…”

Section: Measurement Of Imtmentioning

confidence: 99%

Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: The Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS)

et al. 2011

Self Cite

View full text Add to dashboard Cite

A New Automated Computerized Analyzing System Simplifies Readings and Reduces the Variability in Ultrasound Measurement of Intima-Media Thickness

Cited by 334 publications

References 16 publications

Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA study

Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA study

Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: The SABPA Study

Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: The Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS)

Contact Info

Product

Resources

About