A new atypical antipsychotic: quetiapine-induced sexual dysfunctions

Atmaca, Murad; Kuloğlu, Murat; Tezcan, Ertan

doi:10.1038/sj.ijir.3901260

Cited by 35 publications

(25 citation statements)

References 7 publications

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“…Unlike the more traditional and lengthy scales for assessing sexual dysfunctions, the ASEX can be completed in approximately 5 minutes 27 , it is a brief 5-item questionnaire designed to measure sexual functioning in the following domains: sexual drive, arousal, penile erection/vaginal lubrification, ability to reach orgasm, and satisfaction with orgasm over the past week 25 . The frequency of sexual dysfunctions was very high, a finding consistent with previous studies conducted in different countries 6,11,15,[32][33][34][35] . Females had a much higher rate (79.2%) than males (33.3%).…”

Section: Discussionsupporting

confidence: 80%

A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia

Nunes¹,

Dieckmann²,

Lacaz³

et al. 2009

Rev. psiquiatr. clín.

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Background: Sexual dysfunction is frequent in patients with schizophrenia, it is reported as one of the most distressing antipsychotic's adverse effects and it is directly related to treatment compliance. Objectives: a) to evaluate the accuracy of the Arizona Sexual Experience Scale (ASEX) to identify sexual dysfunction; b) to assess the frequency of sexual dysfunction in a sample of outpatients with schizophrenia and schizoaffective disorder under antipsychotic therapy; and c) to investigate the effect of different antipsychotics on sexual function. Method: Outpatients with schizophrenia or schizoaffective disorder were asked to fulfill both the ASEX and the Dickson Glazer Scale for the Assessment of Sexual Functioning Inventory (DGSFi) at a single interview. Results: 137 patients were interwied. The sensitivity and specificity of the ASEX in relation to DGSFi were: 80.8%, (95% CI = 70.0%-88.5%) and 88.1% (95% CI = 76.5%-94.7%), and the misclassification rate was 9.5%. The ROC curve comparing the ASEX and the DGSFi scores revealed a value of 0.93 (CI = 0.879-0.970), with the optimum cut-off point of ASEX being 14/15. Sexual dysfunction measured was higher in females (79.2%) than in males (33.3%) (χ 2 = 27.41, d.f. = 1, p < 0.001). Discussion: Patients under antipsychotic treatment showed a high level of sexual complaints, and the ASEX proved to be an accurate instrument to identify sexual dysfunction in an outpatient sample of patients with schizophrenia spectrum. Females showed a higher frequency of sexual dysfunctions and sexual drive and ability to reach orgasm were the most affected areas. The use of antipsychotics, especially the combinations, was more likely to impair sexual functioning.

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Section: Discussionsupporting

confidence: 80%

A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia

Nunes¹,

Dieckmann²,

Lacaz³

et al. 2009

Rev. psiquiatr. clín.

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“…Overall, these adverse events are consistent with quetiapine's pharmacology, perhaps with the exception of increased desire for sex. While studies have found antipsychotics, including quetiapine, to typically decrease libido (Atmaca et al 2005;Novick et al 2009), case reports of increased libido have also been found in the clinical literature (Menon et al 2006). In short, while quetiapine was generally well tolerated in this study (only one dose-reduction requested), identifying an optimal dose that can maximize both tolerability and efficacy remains a priority.…”

Section: Discussionmentioning

confidence: 87%

A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving

et al. 2011

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“…Melkersson has also reported an overall sexual dysfunction of 89% due to risperidone. [15] Up to 93% of risperidone-treated patients reported an overall impairment of sexual functioning in yet another study. [16] Even in the case of olanzapine and quetiapine, a frequency of overall sexual impairment, comparable to our study, was observed in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…[18] Of late, another study reported that impaired desire (44%) was the most common sexual dysfunction due to risperidone. [15] One more study reported that impaired libido is commonly seen even with quetiapine. [19] These finding are supported by the present study, which reports an impaired libido of 80% with risperidone, 72% with quetiapine, and 78% with olanzapine.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of sexual dysfunction involving risperidone, quetiapine, and olanzapine

Nagaraj

Pai

Rao

2009

Indian J Psychiatry

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Background:With the advent of newer antipsychotic drugs, side effects such as sexual dysfunction have been a major contributor toward treatment compliance. There are only a few studies that have compared different atypical antipsychotic agents regarding sexual dysfunction. We have not come across any data in this area on Indian population.Aims:To determine and compare the frequency of sexual dysfunction associated with risperidone, olanzapine, and quetiapine, among patients with clinically stable schizophrenia.Settings and Design:It is a cross-sectional hospital-based study. The subjects were recruited for the study by the purposive sampling technique.Materials and Methods:The total sample size was 102, consisting of 25 each in the quetiapine and risperidone groups, 22 in the olanzapine group, and 30 healthy volunteers. A Brief Psychiatric Rating Scale and Sexual Functioning Questionnaire (SFQ) were administered. The Kruskal Wallis test was used to compare the variables in the demographic data and the mean chlorpromazine equivalent doses of the study groups. To analyze the sexual dysfunction, the mean scores on all the domains of sexual functioning in SFQ were compared across the study groups using the Chi square test, for proportions.Results and Conclusion:Twenty-three percent of the healthy volunteers had some impairment in one or more domains of sexual functioning. For the medication groups this was 96, 88, and 90%, respectively for risperidone, quetiapine, and olanzapine. However, there was statistically no significant difference across the study groups although it was relatively less with quetiapine.

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A new atypical antipsychotic: quetiapine-induced sexual dysfunctions

Cited by 35 publications

References 7 publications

A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia

A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia

A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving

A comparative study of sexual dysfunction involving risperidone, quetiapine, and olanzapine

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