A new approach to vocal cord leukoplakia and evaluation of proton pump ınhibitor treatment

Göktaş, Seda Sezen; Doğan, Remzi; Yenigün, Alper; Çalım, Ömer Faruk; Özturan, Orhan; Tuğrul, Selahattin

doi:10.1007/s00405-018-05273-9

Cited by 14 publications

(34 citation statements)

References 20 publications

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“…From these, 64 were related to VF granuloma, 129 to laryngotracheal stenosis, 100 to laryngeal infections, and 48 to leukoplakia. Among these articles, 31 met our inclusion criteria and were kept for analysis ( Figure 1 ): 8 related to VF granuloma ( Table 1 ), 20-27 4 to laryngeal infections ( Table 1 ), 28-31 5 to leukoplakia ( Table 2 ), 7,32-35 and 10 to laryngotracheal stenosis ( Table 3 ). 36-45 Four additional basic research studies were identified concerning the relationship between reflux and the development of laryngotracheal stenosis.…”

Section: Resultsmentioning

confidence: 99%

“…This potential association was indirectly supported by Yang et al and Sezen Goktas et al in their recent studies. 7,34 Yang et al identified LPR symptoms and esophagitis in 31.8% of patients with leukoplakia, but they included patients with a history of smoking, oropharyngeal cancer, or head and neck radiation. 34 Sezen Goktas et al observed a leukoplakia regression in 29% of patients treated by PPI therapy.…”

Section: Resultsmentioning

confidence: 99%

“…7,24-27,29,32,33,37-39,42,45 Among these studies, some authors considered GERD symptoms for the diagnosis without considering LPR-associated complaints. 7,32,39,42,45 The objective approaches used for the reflux diagnosis included x-ray 20 ; gastrointestinal endoscopy findings 20,34 ; single-probe, 20,43 dual-probe, 21-23,28 triple-probe, 36,40 or oropharyngeal 41 pH monitoring; manometry 20 ; and pepsin detection. 30,31,35 Impedance pH was used in 1 study, but the authors did not consider the nonacid data.…”

Section: Resultsmentioning

confidence: 99%

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Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review

Lechien¹,

Akst

Saussez

et al. 2020

Otolaryngol.--head neck surg.

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Objectives To investigate the existing published evidence supporting the role of laryngopharyngeal reflux (LPR) in the development of the select nonfunctional laryngeal diseases of laryngotracheal stenosis, granuloma, leukoplakia, and laryngeal infections Data Sources PubMed, Cochrane Library, and Scopus. Review Methods A systematic review was performed by 3 independent investigators for studies providing information about the prevalence and role of LPR in the development of laryngotracheal stenosis, granuloma, leukoplakia, and laryngeal infections. Diagnostic criteria and clinical outcome evaluation of included studies were analyzed with PRISMA criteria. Results Of the 64 relevant publications, 27 clinical and 4 basic science studies were included. Ten studies used objective reliable examinations for LPR diagnosis (eg, dual- or triple-probe or oropharyngeal pH monitoring, multichannel intraluminal impedance–pH monitoring, or pepsin detection). According to the bias analysis and the results of studies, the association between LPR and laryngotracheal stenosis, leukoplakia, laryngeal papillomatosis, or vocal fold granuloma remains poorly demonstrated. There is a notable heterogeneity among included studies regarding their inclusion criteria, diagnostic methods, and clinical outcome evaluation. Although some experimental findings support the involvement of bile salts and other gastroduodenal proteins active in alkaline pH, no included clinical studies assessed the role of nonacid and mixed reflux through multichannel intraluminal impedance–pH monitoring. Conclusion The involvement of LPR in the development of leukoplakia, laryngotracheal stenosis, vocal fold granuloma, and laryngeal papillomatosis is currently not demonstrated. The potential relationship between LPR and these select nonfunctional laryngeal diseases must be confirmed through future clinical and experimental studies considering acid, nonacid, and mixed LPR.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review

Lechien¹,

Akst

Saussez

et al. 2020

Otolaryngol.--head neck surg.

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“…According to both laryngologists and non-laryngologists, poor diet (42.7%), non-compliance with treatment (18.7%), severity of reflux (12.3%), and nonacid LPR are the most important causes of resistance to treatment. Of otolaryngologists, 16.4% responded that they did not know possible causes of treatment failure. The management of patients with recalcitrant LPR varies significantly between laryngologists and non-laryngologists (P = .001).…”

Section: Causes and Management Of Recalcitrant Lprmentioning

confidence: 99%

“…Since then, an increasing number of studies support association of LPR with the development of many prevalent ear, nose, and throat (ENT) diseases such as chronic rhinosinusitis, 8 acute and chronic media otitis, [9][10][11] or cancer. 12,13 The involvement of LPR in ENT diseases is particularly high in laryngeal diseases, such as laryngotracheal stenosis, 14 spasmodic dysphonia, 15 leukoplakia, 16,17 granuloma, 18 and benign lesion of the vocal folds. 19 However, the current knowledge and practices of laryngologists have never been extensively assessed or perhaps compared with non-laryngologists.…”

Section: Introductionmentioning

confidence: 99%

Do Laryngologists and General Otolaryngologists Manage Laryngopharyngeal Reflux Differently?

et al. 2020

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Objective To investigate current practices of laryngologists and non‐laryngologists in management of Laryngopharyngeal Reflux (LPR). Methods An online survey was sent to members of otolaryngology societies about LPR, and subgroup analysis was performed between laryngologists and non‐laryngologists. This survey was conducted by the LPR Study Group of Young Otolaryngologists of the International Federation of Otolaryngological Societies. Results A total of 535 otolaryngologists completed the survey. Among them, 127 were laryngologists and 408 were non‐laryngologists. Collectively, symptoms most commonly attributed to LPR are cough after lying down/meal, throat clearing, and acid brash; most common findings are thought to be arytenoid erythema and posterior commissure hypertrophy. Respectively, 12.5% and 5% of non‐laryngologists and laryngologists believe that ≥50% of LPR patients suffer from heartburn (P = .010). Non‐laryngologists are more aware about some extra‐laryngeal findings associated with LPR (eg, pharyngeal erythema) than laryngologists. Neither laryngologists nor non‐laryngologists associated development of benign lesions of the vocal folds with reflux. The management of LPR substantially differs between groups, with laryngologists indicating increased awareness of (impedance)‐pH monitoring as well as the prevalence and treatment of nonacid/mixed LPR. Conversely, non‐laryngologists are much more likely to include gastroenterology referral in their management of presumed LPR. Respectively, 44.8% and 27.6% of non‐laryngologists and laryngologists believe themselves not sufficiently knowledgeable about LPR. Conclusions Significant differences exist between laryngologists and non‐laryngologists in diagnosis and treatment of LPR. Overall only one‐third of responders believe themselves to be sufficiently educated about LPR. Level of Evidence 4 Laryngoscope, 130:E539–E547, 2020

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Polymorphisms of acetaldehyde dehydrogenase 2 and alcohol dehydrogenase 1B on the malignant transformation of vocal cord leukoplakia: A Chinese cohort

Han

Liang

et al. 2022

Molecular Carcinogenesis

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Severe dysplasia of vocal cord leukoplakia (VCL) is more likely to occur in laryngeal carcinoma. Alcohol dehydrogenase and acetaldehyde dehydrogenase are both important enzymes in alcohol metabolism. This study aimed to investigate the incidence rate of malignant transformation in patients with VCL and the role of drinking habits and ALDH2 and ADH1B genetic polymorphisms in the malignant transformation of VCL. From January 2007 to January 2017, 136 cases of VCL were included in this retrospective analysis. Information on medical history, alcohol and tobacco consumption habits, ALDH2 and ADH1B genotypes, gastroesophageal reflux, and clinical pathological characteristics of VCL was collected. As a result, patients had a median follow‐up of 9.6 years (interquartile range: 7.5–12.5 years). Twenty‐three of 136 VCL patients finally developed laryngeal carcinoma, resulting in a cumulative malignant transformation rate of 16.9%. Cox regression analysis demonstrated that the independent risk factors for the malignant transformation of VCL included age over 60 years (hazard ratio [HR]: 13.872, p < 0.001), ALDH2 *2 allele status (HR: 9.694, p < 0.001), alcohol (HR: 10.011, p < 0.001) and tobacco (HR: 8.869, p < 0.001) exposure after operation, and drinking frequency (HR: 2.178, p = 0.016). Therefore, among patients over 60 years old, an ALDH2‐inactivating mutation and excessive ethanol and tobacco consumption are potential contributors to the malignant transformation of VCL.

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A new approach to vocal cord leukoplakia and evaluation of proton pump ınhibitor treatment

Cited by 14 publications

References 20 publications

Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review

Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review

Do Laryngologists and General Otolaryngologists Manage Laryngopharyngeal Reflux Differently?

Polymorphisms of acetaldehyde dehydrogenase 2 and alcohol dehydrogenase 1B on the malignant transformation of vocal cord leukoplakia: A Chinese cohort

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