A new approach to the synthesis of substituted 4-imidazolidinones as potential antiviral and antitumor agents

Khodair, Ahmed I.; Bertrand, Philìppe

doi:10.1016/s0040-4020(98)00170-7

Cited by 90 publications

(41 citation statements)

References 21 publications

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“…Compounds derived from nitroimidazole ring system (Table 1) form the basis of several important drugs exhibiting novel biological activities [1,2]. Among these, metronidazole and tinidazole are well-known antimicrobial drugs as well as sensitizers of hypoxic tumors in conjunction with radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric determination of tinidazole in pharmaceutical tablets using carbon paste electrode

Taye¹,

Amare²

2016

Bull. Chem. Soc. Eth.

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ABSTRACT. Cyclic voltammetry was used to study the electrochemical behavior of tinidazole at carbon paste electrode. Tinidazole showed an irreversible reduction peak at about -440 mV. The differential pulse voltammetric peak current of tinidazole showed linear dependence on concentration in the range 5.0-200 μM with LOD and LOQ of 5.1  10 -7 and 1.7  10 -6 μM, respectively. Relative to most of the reported works on the determination of tinidazole, the developed method using carbon paste electrode which is an environmentally friendly, cheap, and simple working electrode exhibited linear dependence of peak current on concentration in the lower concentration region with relatively low LOD. Excellent recovery results with low % RSD for spiked standard tinidazole in tablet samples showed the potential applicability of the developed method for the determination of tinidazole in real samples.

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Section: Introductionmentioning

confidence: 99%

Voltammetric determination of tinidazole in pharmaceutical tablets using carbon paste electrode

Taye¹,

Amare²

2016

Bull. Chem. Soc. Eth.

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“…Antimicrobial 13 , antiviral, 14,15 inhibitors of Methionine Aminopeptidase-2, 16 Anhydrase inhibitors, 17 anti-cancer 18 , antiinflammatory, 19 inhibitors of the HIV-1, 20 analgesic 21 and antioxidant 22 .As well the compounds of Schiff base derivatives displayed broader properties and applications such as nonlinear optical devices 23 liquid crystalline 24,25 , dyes 26 , biological [27][28][29] and pharmaceutical 30 applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Ability of New 5-amino-1,2,4-Triazole Derivatives Containing 2,6-dimethoxyphenol

Hussain¹

2016

Orient. J. Chem

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4-amino-3-(4-(((4-hydroxy-3,5dimethoxybenzyl)oxy)methyl)phenyl)-1,2,4-triazole-5-thione was synthesized by to method the first one from melt reaction of 4-(((4-hydroxy-3,5-dimethoxybenzyl) oxy)methyl)benzoic acid with Thiocarbonyldihydrazide, the second method from convert the corresponded acid hydrazide to potassium 2-(4-(((4-hydroxy-3,5-dimethoxybenzyl)oxy)methyl) benzoyl)hydrazinecarbodithioate salt then react with hydrazine hydrate. Newly Schiff base (7a-7f) were synthesized from reaction the 4-amino-1,2,4-triazol with substituted hydroxybenzaldehyde. The resulting compounds were characterized by IR, 1 H-NMR, 13 C-NMR, and HRMS data. 2,2-Diphenyl-1-picrylhydrazide (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to screened the antioxidant properties of the synthesized compounds. Compounds 7d , 7e and 7f exhibited significant free-radical scavenging ability in both assays.

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“…These compounds are also valuable intermediates for synthesis of heterocyclic compounds [1], show biological activities including antibacterial [2], antifungal [3] and antitumor [4], form complexes with transition metals [5], and are used as nonlinear optical materials [6] and in designing of liquid crystals [7].…”

Section: Introductionmentioning

confidence: 99%

Tautomerism in 2-ketomethylquinolineazines

Loghmani-Khouzani¹,

Minaeifar²,

Gawinecki³

2013

Journal of Molecular Structure

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A new approach to the synthesis of substituted 4-imidazolidinones as potential antiviral and antitumor agents

Cited by 90 publications

References 21 publications

Voltammetric determination of tinidazole in pharmaceutical tablets using carbon paste electrode

Voltammetric determination of tinidazole in pharmaceutical tablets using carbon paste electrode

Synthesis and Antioxidant Ability of New 5-amino-1,2,4-Triazole Derivatives Containing 2,6-dimethoxyphenol

Tautomerism in 2-ketomethylquinolineazines

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