A new approach to target chemistry for the iodine-123 production via the 124Te(p, 2n) reaction

Production of Some Medically Important Short-Lived Neutron-Deficient Radioisotopes of Halogens

“…There are four possible routes for the production of 75 Br, namely the 3 He-or α-particle induced reactions on arsenic, the p-or d-induced reactions on enriched 76 Se, β + EC the 75 Kr -r* 75 Br precursor system, and the 4.2 min 78 Kr (ρ, a) 7S Br reaction on enriched 78 Kr.…”

“…76] and considerable advances in targetry and chemical separation of radioiodine have been reported [cf. 77,78,80,81]. Two approaches have been utilized.…”

“…Some mixed arsenic oxides were tried but were found to be suitable only for low to medium current irradiations [42,45], The intermetallic compound Pb 78 Se, investigated at BNL, was foünd to withstand beam currents up to 15 μ A. The separation of radiobromine and recovery of the enriched 78 Se, however, place heavy demand on radiochemical work. As far as the 77 Kr->- 77 Br precursor method is concerned, an on-line system for removing 77 Kr from a NaBr target was first reported by the Jülich group [46], However, the system can withstand only medium power densities.…”

“…The 78 Kr(p, a) 75 Br reaction may be feasible [66] for medium scale production at low energy machines if technology for handling highly expensive 78 Kr is developed; large batch yields, however, are not to be expected. The (p, 2n) and (d, 3n) reactions on 76 Se are expected to give very high thick-target yields.…”

“…A summary of the direct methods of production [73][74][75][76][77][78][79][80][81][82][83][84] is given in Table 6. These consist of a-and 3 Heparticle induced nuclear reactions on antimony, as well as proton and deuteron induced reactions on isotopically enriched tellurium targets.…”