A New Approach to Fluorinated 4(3H)‐Quinazolinones.

Abstract

A New Approach to Fluorinated 4(3H)-Quinazolinones. -Fluorinated quinazolinones are synthesized based on the reaction of o-halogen substituted benzoyl chlorides with S-ethyl isothiourea and subsequent intramolecular cyclization of the S-ethyl N-benzoylisothioureas obtained. Nucleophilic substitution reactions at positions C-2 and C-7, as well as alkylation at C-1 of quinazolinones are described. (Some yields not given). -(LAYEVA, A. A.; NOSOVA, E. V.; LIPUNOVA, G. N.; TRASHAKHOVA, T. V.; CHARUSHIN*, V. N.; J. Fluorine Chem. 128 (2007) 7, 748-754; Postovsky Inst. Org. Synth., Russ. Acad. Sci., Ekaterinburg 620219, Russia; Eng.) -H. Toeppel 44-152