A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping

Mohammadi, Mehdi; Zare, Mohammad Javad; Madadi, Hojjat; Sellarès, J.; Casals‐Terré, Jasmina

doi:10.1007/s00216-016-9629-2

Cited by 27 publications

(23 citation statements)

References 34 publications

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“…Furthermore, it has been shown that polymeric devices, which are so common in iDEP separations, are not as efficient as glass devices for dissipating heat [118]. Because of the importance of Joule heating effects, several leading DEP research groups have devoted significant efforts toward the assessment and understanding of Joule heating non-linear EK effects [67,89,99,101,119,[122][123][124][125][126][127][128][129][130][131][132].…”

Section: Joule Heating and Electrothermal Flows In Idep Devicesmentioning

confidence: 99%

On the recent developments of insulator‐based dielectrophoresis: A review

2018

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Insulator-based dielectrophoresis (iDEP), also known as electrodeless DEP, has become a well-known dielectrophoretic technique, no longer viewed as a new methodology. Significant advances on iDEP have been reported during the last 15 years. This review article aims to summarize some of the most important findings on iDEP organized by the type of dielectrophoretic mode: streaming and trapping iDEP. The former is primarily used for particle sorting, while the latter has great capability for particle enrichment. The characteristics of a wide array of devices are discussed for each type of dielectrophoretic mode in order to present an overview of the distinct designs and applications developed with iDEP. A short section on Joule heating effects and electrothermal flow is also included to highlight some of the challenges in the utilization of iDEP systems. The significant progress on iDEP illustrates its potential for a large number of applications, ranging from bioanalysis to clinical and biomedical assessments. The present article discusses the work on iDEP by numerous research groups around the world, with the aim of proving the reader with an overview of the state-of-the-art in iDEP microfluidic systems.

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Section: Joule Heating and Electrothermal Flows In Idep Devicesmentioning

confidence: 99%

On the recent developments of insulator‐based dielectrophoresis: A review

2018

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“…Furthermore, modeling these phenomena can lead to highly complex models and resource consuming computations, which may preclude researchers from performing a large number of simulations to test an array of system configurations and conditions, defeating the sole purpose of mathematical modeling. A common approach that has been adopted by several leading research groups in the field of iDEP devices is the use of heuristic correction factors, which are added to a mathematical model in order to reach agreement between the model predictions and experimental results [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

On the use of correction factors for the mathematical modeling of insulator based dielectrophoretic devices

Hill

Lapizco‐Encinas

2019

Electrophoresis

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Mathematical modeling is a fundamental component in the development of new microfluidics techniques and devices. Modeling allows for the rapid testing of new system configurations while saving resources. Microscale electrokinetic (EK) techniques have significantly benefited by the advances in modeling programs and software packages. However, EK phenomena are complex to model, as they dynamically affect system characteristics, including the physical properties of the particles and fluid within the system. Insulator‐based dielectrophoresis (iDEP) is an EK technique that has received important attention during the last two decades. In particular, numerous research groups that study iDEP systems employ a combination of modeling and experimentation for developing new iDEP systems. An important fraction of these research groups has adopted the practice of employing “correction factors” to account for EK phenomena that cannot be accurately predicted in their models due to model complexity and limitations in computing resources. The present review article aims to provide the reader with an overview of the most common approaches in the use of correction factors for the modeling of iDEP systems.

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“…[74][75][76][77][78] Insulated pillars in microchannels change the distribution of electric fields and form strong DEP forces at the edge of insulated structure to capture cells. LaLonde et al presented an insulator-based dielectrophoresis (iDEP) device for the detection and stable capture of low abundant polystyrene particles and yeast cells, as show in Fig.…”

Section: Dielectrophoresismentioning

confidence: 99%

Microfluidics cell sample preparation for analysis: Advances in efficient cell enrichment and precise single cell capture

et al. 2017

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Single cell analysis has received increasing attention recently in both academia and clinics, and there is an urgent need for effective upstream cell sample preparation. Two extremely challenging tasks in cell sample preparation-highefficiency cell enrichment and precise single cell capture-have now entered into an era full of exciting technological advances, which are mostly enabled by microfluidics. In this review, we summarize the category of technologies that provide new solutions and creative insights into the two tasks of cell manipulation, with a focus on the latest development in the recent five years by highlighting the representative works. By doing so, we aim both to outline the framework and to showcase example applications of each task. In most cases for cell enrichment, we take circulating tumor cells (CTCs) as the target cells because of their research and clinical importance in cancer. For single cell capture, we review related technologies for many kinds of target cells because the technologies are supposed to be more universal to all cells rather than CTCs. Most of the mentioned technologies can be used for both cell enrichment and precise single cell capture. Each technology has its own advantages and specific challenges, which provide opportunities for researchers in their own area. Overall, these technologies have shown great promise and now evolve into real clinical applications. Published by AIP Publishing. [http://dx

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A new approach to design an efficient micropost array for enhanced direct-current insulator-based dielectrophoretic trapping

Cited by 27 publications

References 34 publications

On the recent developments of insulator‐based dielectrophoresis: A review

On the recent developments of insulator‐based dielectrophoresis: A review

On the use of correction factors for the mathematical modeling of insulator based dielectrophoretic devices

Microfluidics cell sample preparation for analysis: Advances in efficient cell enrichment and precise single cell capture

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