A new approach for the identification of modifier genes in heart failure

Identifying modifier genes of monogenic disease: strategies and difficulties

“…Another example involves dilated cardiomyopathy, where candidate genes in diVerent pathways are being studied, in particular the beta-adrenergic pathway and the renin-angiotensin-aldosterone system. New approaches have also been used based on animal models, which allow a better control of the environment (Komajda and Charron 2004). In a candidate gene or pathway approach, both linkage and association information may be used as it is important to recall that these two kinds of information are complementary and not redundant (Clerget-Darpoux and Bonaiti-Pellie 1992).…”

Gene Profiling, Energy Metabolism, and Remodeling of the Failing Heart

“…Komajda and Charron 35 have noted that because of the small size of the populations available studies cannot be considered as definitive because of their lack of replication and ethnic stratification. Komajda and Charron 35 have noted that because of the small size of the populations available studies cannot be considered as definitive because of their lack of replication and ethnic stratification.…”

“…Komajda and Charron 35 have noted that because of the small size of the populations available studies cannot be considered as definitive because of their lack of replication and ethnic stratification. 35 For example, the modifier loci identified may not be specific to the animal HF induced by CSQ overexpression, implying that studies of other models of HF are warranted. This low statistical power prevents the analysis of gene-gene and gene-environment interactions, which are likely to play a major role in this multifactorial syndrome as HF.…”