A new application of surfactant-free microemulsion: Solubilization and transport of drugs and its transdermal release properties

Han, Ying; Liu, Shuhui; Du, Yifan; Li, Deqiang; Pan, Ning; Chai, Jinling; Li, Dejie

doi:10.1016/j.jtice.2022.104473

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…31,32 However, SFME has mainly been constructed using compounds that are not cosmetically approved and is applied to solubilize hydrophobic bioactive molecules. 33 For example, Chai et al 34 found that diethyl malonate/ethanol/water SFME has a strong solubilization ability for biomolecules, such as riboflavin. Li's team 35 developed an SFME using ethyl benzoate, ethanol, and water and investigated its applications in the encapsulation and delivery of curcumin.…”

Section: ■ Introductionmentioning

confidence: 99%

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Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin

Zhang,

Song,

Zhao

et al. 2024

Langmuir

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Surfactant-free microemulsions (SFMEs) exhibited remarkable advantages and potential, attributed to their similarity to traditional surfactant-based microemulsions and the absence of surfactants. Herein, a novel SFME was developed utilizing cosmetically approved materials, such as short-chain alcohol as an amphi-solvent, triethyl citrate (TEC) as the nonpolar phase, and water as the polar phase. 1,2-Pentanediol (PtDO)/TEC/water combination can form the largest monophasic zone, accounting for ∼74% of the total phase diagram area, due to an optimal hydrophilic (water)–lipophilic (TEC) balance. Comparable to surfactant-based microemulsion, PtDO/TEC/water SFME can also be categorized into three types: water-in-oil, discontinuous, and oil-in-water. As TEC or water is increased, or PtDO is decreased, the nanoaggregates in PtDO/TEC/water SFME grow from <5 nm to tens of nanometers. The addition of α-arbutin (ABN) does not disrupt PtDO/TEC/water SFME, but rather enhances its formation, resulting in a larger monophasic area and consistent size (2.8–3.8 nm) through participating in interface assembly. Furthermore, ABN-loaded PtDO/TEC/water SFME exhibits remarkable resistance to dilution, exceptional stability, and minimal irritation. Notably, PtDO/TEC/water SFME significantly boosts ABN’s solubility in water by 2 times, its percutaneous penetration rate by 3–4 times, and enables a slow-release DPPH• radical scavenging effect. This SFME serves as a safe and cosmetically suitable nanoplatform for the delivery of bioactive substances.

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Section: ■ Introductionmentioning

confidence: 99%

“…However, SFME has mainly been constructed using compounds that are not cosmetically approved and is applied to solubilize hydrophobic bioactive molecules . For example, Chai et al found that diethyl malonate/ethanol/water SFME has a strong solubilization ability for biomolecules, such as riboflavin.…”

Section: Introductionmentioning

confidence: 99%

Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin

Zhang,

Song,

Zhao

et al. 2024

Langmuir

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“…Noteworthily, the microemulsion without the surfactant composition was defined as surfactant-free microemulsion (SFME), which showed great solubilization, less adsorption, as well as low toxicity . The SFMEs were already used in various fields, such as synthesis of nanoparticles, photocatalysts, and solubilization of drugs. − Recently, the SFME composed of tertiary amines showed CO 2 -regulated microstructural transitions, implying the recyclability of SFME. − Some scholars also conducted numerous research studies on CO 2 , e.g., the significance of in situ CO 2 for enhanced oil recovery, the research in carbon capture, transportation, utilization, and storage, and the Karstified geothermal reservoirs. − And tertiary amines were commonly regarded as CO 2 convertible hydrophilic solvents. − Liu et al prepared the CO 2 response SFME system by combining N , N -dimethylcyclohexylamine, N , N -dimethylethanolamine, and water and verified its responsiveness . Jiang et al proposed the extraction application of CO 2 -responsive SFME consisting of hexane/ tert -butanol/water in cleaning oil-based cuttings .…”

Section: Introductionmentioning

confidence: 99%

Sustainable Utilization of Surfactant-Free Microemulsion Regulated by CO₂ for Treating Oily Wastes: A Interpretation of the Response Mechanism

Song,

Jia,

Zhang

et al. 2023

Langmuir

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Surfactant-free microemulsions (SFMEs) have been explored extensively to avoid the residual surfactant problem caused by traditional surfactant microemulsions. Many researchers focused on the SFMEs with tertiary amine, which exhibited the typical CO 2 response behavior. In this study, the phase diagram of the SFMEs consisting of tripropylamine (TPA), ethanol, and water was readily prepared via the measurements of electrical conductivity. The CO 2 response behavior of SFME was confirmed by determination of conductivity and measurement of the average diameter of SFME, which was mainly dependent on the protonation of TPA induced by the additional CO 2 . The transition of protonated TPA to a more hydrophilic nature from lipophilicity to hydrophilicity should be responsible for the variation of SFME average diameter. In addition, the SFMEs exhibited remarkable solubilizing capacity of crude oil, and three types of SFMEs achieved more than 80% oil removal rate in the washing process of oil sands. It was noted that both oil-in-water and bicontinuous SFMEs could be circularly utilized at least three times with a relatively high oil removal rate (%). Our work provided the insight perspective on the mechanism of SFMEs with a CO 2 response behavior.

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Novel stable and high-loaded natural UV filter microemulsion based on optimized emulsifiers system

Su,

Luo,

Zheng

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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A new application of surfactant-free microemulsion: Solubilization and transport of drugs and its transdermal release properties

Cited by 6 publications

References 49 publications

Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin

Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin

Sustainable Utilization of Surfactant-Free Microemulsion Regulated by CO₂ for Treating Oily Wastes: A Interpretation of the Response Mechanism

Novel stable and high-loaded natural UV filter microemulsion based on optimized emulsifiers system

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A new application of surfactant-free microemulsion: Solubilization and transport of drugs and its transdermal release properties

Cited by 6 publications

References 49 publications

Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin

Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin

Sustainable Utilization of Surfactant-Free Microemulsion Regulated by CO2 for Treating Oily Wastes: A Interpretation of the Response Mechanism

Novel stable and high-loaded natural UV filter microemulsion based on optimized emulsifiers system

Contact Info

Product

Resources

About

Sustainable Utilization of Surfactant-Free Microemulsion Regulated by CO₂ for Treating Oily Wastes: A Interpretation of the Response Mechanism