A New Apocarotenoid of Cinnamomum burmannii

Lin, Rong-Jyh; Kao, C. L.; Liu, S. L.; Yeh, H. C.; Song, Ping; Li, H. T.; Wang, Hui‐Min David; Chang, Hong-Po; Chen, C. Y.

doi:10.1007/s10600-020-03103-1

Cited by 7 publications

(2 citation statements)

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“…BURA (MW 296) was purified from the roots of C. burmannii as previously described [21]. Broadly, the roots of C. burmannii (203.4 g) were air-dried for MeOH (1 L × 3) extraction.…”

Section: Bura Preparationmentioning

confidence: 99%

“…Some homosesquiterpenoids [20] and amides have been isolated from C. burmannii stems. Using C. burmannii roots, we identified a new apocarotenoid and a novel β-ionone derivative, burmannic acid (BURA) [21], with a carboxylic acid group binding to C-5 of 3-hydroxy-5,6-epoxy-β-ionone. However, its molecular functioning has not yet been reported, according to a PubMed search carried out by the authors.…”

Section: Introductionmentioning

confidence: 99%

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Burmannic Acid Inhibits Proliferation and Induces Oxidative Stress Response of Oral Cancer Cells

Liu

Yang

et al. 2021

Antioxidants

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Burmannic acid (BURA) is a new apocarotenoid bioactive compound derived from Indonesian cinnamon; however, its anticancer effect has rarely been investigated in oral cancer cells. In this investigation, the consequences of the antiproliferation of oral cancer cells effected by BURA were evaluated. BURA selectively suppressed cell proliferation of oral cancer cells (Ca9-22 and CAL 27) but showed little cytotoxicity to normal oral cells (HGF-1). In terms of mechanism, BURA perturbed cell cycle distribution, upregulated mitochondrial superoxide, induced mitochondrial depolarization, triggered γH2AX and 8-hydroxy-2-deoxyguanosine DNA damage, and induced apoptosis and caspase 3/8/9 activation in oral cancer cells. Application of N-acetylcysteine confirmed oxidative stress as the critical factor in promoting antiproliferation, apoptosis, and DNA damage in oral cancer cells.

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“…BURA (MW 296) was purified from the roots of C. burmannii as previously described [21]. Broadly, the roots of C. burmannii (203.4 g) were air-dried for MeOH (1 L × 3) extraction.…”

Section: Bura Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%