A New Antitumor Antibiotic, Kidamycin. I

Kanda, Nobuo

doi:10.7164/antibiotics.24.599

Cited by 50 publications

(7 citation statements)

References 3 publications

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“…Eighteen monosaccharide units are represent among pluramycin glycosides where N-alkyl aminosugars are a predominate feature known to be critical for pluramycin metabolite DNA interaction and cytotoxicity. 940,1153,1168,[1172][1173][1174][1175][1176][1177] Among the sugars found as C-…”

Section: Pluramycinsmentioning

confidence: 99%

A comprehensive review of glycosylated bacterial natural products

et al. 2015

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A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites reported in the scientific literature up through early 2013 is presented. This comprehensive analysis of 15 940 bacterial natural products revealed 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique opportunities for future biosynthetic study and glycodiversification efforts.

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Section: Pluramycinsmentioning

confidence: 99%

A comprehensive review of glycosylated bacterial natural products

et al. 2015

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“…In regard to the structures described in the current study, the closest structural relatives of the saliniquinones include the indomycinones,[20] and the aglycones of kidamycin and hedamycin. [5, 21, 22] Hedamycin shares an identical core skeleton with 5 and 6 but fashions a six carbon bis-epoxide side chain at C-2 and two C-glycosylated amino sugars at C-5 and C-8. In a cloning experiment, Bililign et al were the first to describe the biosynthetic gene cluster responsible for the production of hedamycin in Streptomyces griseoruber .…”

Section: Discussionmentioning

confidence: 99%

Saliniquinones A - F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine Actinomycete Salinispora arenicola

et al. 2010

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Six new anthraquinone-γ-pyrones, saliniquinones A–F (1–6), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomycete Salinispora arenicola (strain CNS-325). Their structures were determined by analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data. The relative and absolute configurations of compounds 1–6 were determined by analysis of NOESY NMR spectroscopic data and by comparison of circular dichroism and optical rotation data with model compounds found in the literature. Saliniquinone A (1) exhibited potent inhibition of the human colon adenocarcinoma cell line (HCT-116) with an IC50 of 9.9 × 10−9 M. In the context of the biosynthetic diversity of S. arenicola, compounds 1–6 represent secondary metabolites that appear to be strain specific and thus occur outside of the core group of compounds commonly observed from this species.

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“…Aryl and heteroaryl C -glycosides constitute an important class of stable glycoconjugates of biological and therapeutic relevance, , as evidenced by representative examples, including the antidiabetic drug Steglatro, the immunomodulator bergenin, and the antibiotic kidamycin (Figure ).…”

Section: Introductionmentioning

confidence: 99%