A new antimalarial agent; effects of extracts of Artemisia diffusa against Plasmodium berghei

Rustaiyan, Abdolhossein; Nahrevanian, Hossein; Kazemi, Masoud; Larijani, K.

doi:10.1055/s-2007-987000

Cited by 22 publications

(24 citation statements)

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“…233 The extract of the aerial parts of Artemisia diffusa contains tehranolide 399, a new type of sesquiterpene lactones with an endoperoxide group. 234 Successful biomimetic syntheses of the litseaverticillol family of sesquiterpenes have been achieved, using singlet oxygen chemistry. 235 In this work, the structure of the previously reported litseaverticillol E 236 has been revised to 400.…”

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confidence: 99%

Peroxy natural products

Liu

2013

Nat. Prod. Bioprospect.

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confidence: 99%

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Liu

2013

Nat. Prod. Bioprospect.

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“…In this study, aiming to search for new effective anti-malarial agent, we found, for the first time, in vitro anti-plasmodial activities of the Tehranolide. In addition to anti-malarial effects of Tehranolide on murine malaria parasites, which were published earlier by this group of authors (Rustaiyan et al, 2009a(Rustaiyan et al, , 2011Taherkhani et al, 2013), it may have similar ability to apply for human malaria therapy. Alternatively, new therapies can be performed based on the use of combination therapy such as artediffusin combination therapy (Rustaiyan et al, 2011).…”

Section: Discussionmentioning

confidence: 88%

“…The results of in vivo trial in mice indicated no significant toxicity after treatment with Tehranolide extract (Rustaiyan et al, 2009a(Rustaiyan et al, , 2011. Results indicated no effects of low concentration of Tehranolide on parasitaemia (2 mg mLG 1 ), therefore, in this study, the concentrations of 10, 30 and 50 mg mLG 1 were considered for comparison of antiplasmodial activities.…”

Section: Resultsmentioning

confidence: 99%

“…The search for new drugs and drug targets is a consistent demand in respect of this disease. Traditional medicinal plants and Artediffusin (Tehranolide) is reported as a new candidate of anti-malarial agent (Rustaiyan et al, 2009a;Rustaiyan and Vahedi, 2012). Tehranolide, is reported to have some antiparasitic properties in vivo on chloroquine-sensitive P. berghei murine malaria (Rustaiyan et al, 2009b;Taherkhani et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Previously the anti-malaria activity of Artediffusin (Tehranolide) a sesquiterpene lactone with an endoperoxide group on P. berghei in vivo was investigated ( Fig. 1) (Rustaiyan et al, 2009a(Rustaiyan et al, , 2011. …”

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confidence: 99%

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An Investigation on Anti-malarial Effects of Tehranolide Isolated from Artemisia diffusa Against Human Malaria Parasite, Plasmodium falciparum in vitro

Rustaiyan¹,

Nahrevania²,

Zamani³

et al. 2015

Research J. of Parasitology

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Tehranolide which has been isolated from Artemisia diffusa has similar functional group to Artemisinin. More attention has been paid to Artemisia annua L., for its anti-plasmodial properties. In the present study, we investigated the anti-malarial effects of Tehranolide against human malaria parasite, Plasmodium falciparum in vitro. The chloroquine (CQ)-sensitive strain (3D7) of P. falciparum was continuously cultured in PRMI medium with addition of HT serum Albumax, RBC of O + blood group, 05% CO 2 at 37°C. The anti-malarial activity was determined by using different concentrations including 10, 30, 50 mg mLG 1 of Tehranolide were made in drug vehicle including distilled water, methanol, DMSO and applied for therapy. Percentage of parasitaemia was counted after 24, 48 and 72 h after treatment for each concentration. Results indicated no effects of low concentration of Tehranolide on parasitaemia, however the concentrations of 10, 30 and 50 mg mLG 1 represented their anti-plasmodial activities. The cytotoxic effects of high concentration occurred by destroying both parasites and RBCs in culture medium. Inhibition concentration of 50% (IC 50 ) on plasmodial survival was observed at concentration of 10 mg mLG 1 after 48-72 h of treatment. It is concluded that, Tehranolide seems to be a promising drug exhibiting good anti-malarial effects in this human malaria P. falciparum model in vitro. However, more research is required before Tehranolide can be used for malaria treatment in human cases.

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An investigation on the volatile composition of some Artemisia species from Iran

Costa

Fina

Valentino

et al. 2009

Flavour & Fragrance J

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The compositions of the essential oils of four species of Artemisia (A. kopetdaghensis Krasch ex. Poljakov, A. austriaca Jacq., A. oliveriana J. Gay ex. Besser, A. diffusa Krasch ex. Poljakov), endemic of Iran, were studied by means of GC-MS and GC-FID, using the internal standard method and relative response factors. Around 150 compounds were determined in total, representing 82.1 g/100 g in A. austriaca, 57.4 g/100 g in A. kopetdaghensis, 84.1 g/100 g in A. diffusa and 71.6 g/100 g in A. oliveriana, respectively.

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A new antimalarial agent; effects of extracts of Artemisia diffusa against Plasmodium berghei

Cited by 22 publications

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Peroxy natural products

Peroxy natural products

An Investigation on Anti-malarial Effects of Tehranolide Isolated from Artemisia diffusa Against Human Malaria Parasite, Plasmodium falciparum in vitro

An investigation on the volatile composition of some Artemisia species from Iran

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