A New Antigen of B. Typhosus

Félix, Arthur; Pitt, R. M.

doi:10.1016/s0140-6736(00)44360-6

Cited by 161 publications

(57 citation statements)

References 7 publications

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“…All the positive sera were examined repeatedly against several strains of the inagglutinable type and most of them were also tested for Vi agglutination after the H and 0 agglutinins had been removed by absorption with the strain H901, which is devoid of Vi antigen. The Vi titres recorded in the table represent those determined with the strain " Watson " as test strain and are therefore directly comparable with the titres of the rabbit and horse immune sera published in previous papers (Felix and Pitt, 1934b;Felix, 1935).…”

Section: Antibody In the Blood Serum Of Patients And Convalescentssupporting

confidence: 83%

“…For the same reason the agglutination tests were performed on the spot, to avoid variation in the content of Vi antigen of the cultures occurring during transport from one laboratory to the other. The technique of the agglutination tests was as described in a previous paper (Felix and Pitt, 1934a), and the procedure adopted in the present investigation is illustrated in Table I.…”

Section: Antigen In Freshly Isolated Strains Of B Typhosus All Thmentioning

confidence: 99%

“…The contrast in this respect between strains of the intermediate type and those of the highly virulent type is very sharp. It may well be recalled that one of the most virulent and inagglutinable strain (Ty2), used in the experiments of Felix and Pitt (1934a) was isolated so long ago as 1918 and has since been maintained on plain agar in many hundreds of subcultures.…”

Section: Antigen In Freshly Isolated Strains Of B Typhosus All Thmentioning

confidence: 99%

“…From previous experiments with old laboratory strains (Felix and Pitt, 1934b) evidence has already been obtained of the presence of Vi antigen in strains of intermediate agglutinability and virulence, which represent the most common type of B. typhosus. This is now corroborated by the results of the investigation of cultures freshly isolated from typhoid patients.…”

Section: Antigen In Freshly Isolated Strains Of B Typhosus All Thmentioning

confidence: 99%

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The Occurrence of Typhoid Bacilli Containing Vi Antigen in Cases of Typhoid Fever and of Vi Antibody in their Sera

Félix

Krikorian

Reitler

1935

J. Hyg.

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The investigation recorded in the present paper was undertaken as a corollary to the clinical trials with a new antityphoid serum, the results of which were recently published (Felix, 1935). Its object was to enquire into:(i) the occurrence of Vi antigen in strains of B. typhosus freshly isolated from cases of typhoid fever;(ii) the occurrence of Vi antibody in the blood serum of typhoid patients and convalescents.

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Section: Antibody In the Blood Serum Of Patients And Convalescentssupporting

confidence: 83%

Section: Antigen In Freshly Isolated Strains Of B Typhosus All Thmentioning

confidence: 99%

Section: Antigen In Freshly Isolated Strains Of B Typhosus All Thmentioning

confidence: 99%

Section: Antigen In Freshly Isolated Strains Of B Typhosus All Thmentioning

confidence: 99%

See 2 more Smart Citations

The Occurrence of Typhoid Bacilli Containing Vi Antigen in Cases of Typhoid Fever and of Vi Antibody in their Sera

Félix

Krikorian

Reitler

1935

J. Hyg.

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“…The Vi capsule polysaccharide was first identified as being associated with virulence in mice, and as an antigen distinct from that of O or H antigens [18,19]. Structurally, it is a polymer of Nacetylaminohexuronic acid [20].…”

Section: Capsule Polysaccharide Operonmentioning

confidence: 99%

SPI-7: Salmonella’s Vi-Encoding Pathogenicity Island

Seth-Smith

2008

J Infect Dev Ctries

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Salmonella Pathogenicity Island-7 (SPI-7) is a large, mosaic, genetic island, found in several serovars of Salmonella enterica subsp. enterica associated with systemic disease. As well as encoding genes which may aid its own transmission, it carries genes for potential virulence factors such as Vi antigen, SopE effector and type IVB pili. The stability of SPI-7 is of interest with respect to typhoid fever and related vaccines.

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A New Typhoid Vaccine Composed of the Vi Capsular Polysaccharide

Plotkin

Cam²

1995

Arch Intern Med

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Typhoid is still prevalent in many parts of the world. We reviewed all published and unpublished studies of a newly licensed vaccine composed of the Vi capsular polysaccharide of Salmonella typhi, the causative agent of the disease, which had been licensed previously outside the United States. These included observational studies and double-blind randomized studies done in the United States, Europe, and the developing world in which children and adults unexposed to typhoid or those living in endemic areas were enrolled. A single dose of 25 micrograms of the purified polysaccharide was given by intramuscular injection. The vaccine was well tolerated, inducing only minor reactions in fewer than 10% of subjects. An antibody response occurred in about 90% of subjects and lasted about 3 years. Seroconversion was shown in children as young as 2 years. Protective efficacy was evaluated in two studies conducted in areas in which typhoid is endemic; the efficacy was 55% and 75%, respectively, in adults and in children older than 5 years. The Vi vaccine compares favorably with other typhoid vaccines in regard to safety, patient compliance, immunogenicity, and efficacy. Vi polysaccharide is a well-standardized antigen that is effective in a single parenteral dose, is safer than whole-cell vaccine, and may be used in children 2 years of age or older.

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A New Antigen of B. Typhosus

Cited by 161 publications

References 7 publications

The Occurrence of Typhoid Bacilli Containing Vi Antigen in Cases of Typhoid Fever and of Vi Antibody in their Sera

The Occurrence of Typhoid Bacilli Containing Vi Antigen in Cases of Typhoid Fever and of Vi Antibody in their Sera

SPI-7: Salmonella’s Vi-Encoding Pathogenicity Island

A New Typhoid Vaccine Composed of the Vi Capsular Polysaccharide

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