A New Antibody Recognizing the vIII Mutation of Human Epidermal Growth Factor Receptor

Öhman, Linda; Gedda, Lars; Hesselager, Göran; Larsson, Rolf; Nistér, Monica; Stigbrand, Torgny; Wester, Kenneth; Carlsson, Jörgen

doi:10.1159/000059704

Cited by 34 publications

(2 citation statements)

References 15 publications

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“…Its expression is tightly linked to EGFR gene amplification with some exceptions [7,25]. Furthermore, the antibodies used may also influence the results of EGFRvIII expression [61,69,70]. Concerning prognosis, the data appear somewhat complex due to additional genetic and clinical factors.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Significance of EGFR Gene Amplification and Overexpression in Diffuse Astrocytomas—A Literature Study

Hagen¹,

Torp²

2012

OJPathology

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Epidermal growth factor receptor (EGFR) has been shown to play an important role in the malignant progression of diffuse astrocytomas. Numerous studies have investigated the clinical significance of overexpression and amplification of the EGFR gene in these tumours with ambiguous results. The aim of this study was therefore to review the literature to get the current prognostic and diagnostic status. The PubMed database was used to search for papers in English in the time period 1987-2010 using the following keywords: astrocytoma, glioma, c-erbB1, EGFR, glioblastoma, HER1 and prognosis. Other inclusion criteria were: 1) studies with more than 50 patients; 2) patient age over 18 years; 3) tumour grading according to the latest World Health Organization (WHO) classification (2007) and 4) EGFR overexpression assessed by immunohistochemistry. A total of 47 publications were included and several reported positive correlations between both EGFR gene amplification and overexpression with histological malignancy grade and survival. The results are, however, encumbered with elements of uncertainty involving for instance methodological diversities and small number of patients. Larger studies with standardized procedures are necessary to fully clarify the clinical role of EGFR in human astrocytomas.

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Section: Resultsmentioning

confidence: 99%

Prognostic Significance of EGFR Gene Amplification and Overexpression in Diffuse Astrocytomas—A Literature Study

Hagen¹,

Torp²

2012

OJPathology

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“…However, applying them via systemic administration could lead to systemic toxicity due to the expression of wildtype EGFR on healthy tissues. Despite the generation of EGFRvIII-specific antibodies [65,66,67], implementing them as TRNT vehicles has not reached clinical examination yet.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases

et al. 2019

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Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities. The delicate nature of the brain further complicates the decision of eliminating as much tumorous tissue as possible while protecting healthy tissue. Despite recent advances in immunotherapy, radiotherapy and systemic treatments, prognosis of newly diagnosed patients remains dismal, and recurrence is still a universal problem. Several strategies are now under preclinical and clinical investigation to optimize delivery and maximize the cytotoxic potential of pharmaceuticals with regards to brain tumors. This review provides an overview of targeted radionuclide therapy approaches for the treatment of primary brain tumors and brain metastases, with an emphasis on biological targeting moieties that specifically target key biomarkers involved in cancer development.

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A survey of the year 2002 commercial optical biosensor literature

Rich

Myszka

2003

J of Molecular Recognition

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We have compiled 819 articles published in the year 2002 that involved commercial optical biosensor technology. The literature demonstrates that the technology's application continues to increase as biosensors are contributing to diverse scientific fields and are used to examine interactions ranging in size from small molecules to whole cells. Also, the variety of available commercial biosensor platforms is increasing and the expertise of users is improving. In this review, we use the literature to focus on the basic types of biosensor experiments, including kinetics, equilibrium analysis, solution competition, active concentration determination and screening. In addition, using examples of particularly well-performed analyses, we illustrate the high information content available in the primary response data and emphasize the impact of including figures in publications to support the results of biosensor analyses.

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A New Antibody Recognizing the vIII Mutation of Human Epidermal Growth Factor Receptor

Cited by 34 publications

References 15 publications

Prognostic Significance of EGFR Gene Amplification and Overexpression in Diffuse Astrocytomas—A Literature Study

Prognostic Significance of EGFR Gene Amplification and Overexpression in Diffuse Astrocytomas—A Literature Study

Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases

A survey of the year 2002 commercial optical biosensor literature

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