A new antibacterial compound from Ibicella lutea

Cerdeiras, María Pía; Fernández, José-Antonio; Soubes, Matilde; Vero, Silvana; Ferreira, Fernando; Moyna, Patrick; Olano, I; Vázquez, Álvaro

doi:10.1016/s0378-8741(00)00339-1

Cited by 17 publications

(21 citation statements)

References 13 publications

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“…The bactericidal activities of both ethyl acetate and methanol extracts on both Gram-negative Pseudomonas aeruginosa (ACC) , a multidrug-resistant bacterium at a concentration of (0.100 ± 0.00) mg/mL, and Escherichia coli (ATCC 35150) , multidrug-resistant reference strains also at the same concentration of (0.100 ± 0.00) mg/mL of the plant under investigation, further establish the findings obtained in our previous study [25] that volatile oil from the leaves and flowers of C. citrinus is more effective against Gram-negative bacteria. The high fatty acid content as shown in Tables 1 and 2 of both methanol and ethyl acetate extracts might also contribute to the excellent antimicrobial activity recorded in this work because previous documentation by these researchers [77–79] have attested to the fact that high fatty acid components might be responsible for the antibacterial, anti-inflammatory, and antiviral potentials of Pentanisia prunelloides and Helichrysum pedunculatum . In addition to this, the disparities seen in the antimicrobial properties of both ethyl acetate and methanol extracts might be due to discrepancy in the chemical constituents of the two extracts coupled with some bioactive compounds such as alkaloids, tannins, terpenoids, ether, and phenolic compounds like flavonoids, which are considered to be bacteriostatic and bactericidal as reported in our previous study [25].…”

Section: Resultsmentioning

confidence: 58%

Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus

Larayetan

Ololade

Ogunmola³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Plants are reservoir for potentially useful bioactive compounds, and owing to the rising occurrences of drug resistance to malaria parasites, there is a need to discover and develop new phytochemicals in plant that can be used as antimalarial agents. In this study, we gave a detailed description of the phytochemicals present in both ethyl acetate and methanolic extracts of Callistemon citrinus (C. citrinus) using Gas Chromatography-Mass Spectrometry (GC-MS) analysis; both extracts were also evaluated for their in vitro antimalarial, antitrypanosomal, and cytotoxicity activities against Trypanosoma brucei brucei (T. b brucei) parasites, Plasmodium falciparum (P. falciparum) malaria parasites 3D7 strain, and human cervix adenocarcinoma cells (HeLa cells); in addition, the antimicrobial and antioxidant efficacies were determined using standard methods. Both extracts were characterized by a high amount of fatty acids (52.88 and 62.48%). The ethyl acetate extract exhibited a greater activity with minimum inhibitory concentration (MIC) values ranging from 0.025 to 0.10 mg/mL while the methanol extract ranged from 0.025 to 0.15 mg/mL. Both extracts were bactericidal to Escherichia coli ATCC 35150 (E. coli) and Pseudomonas aeruginosa ACC (P. aeruginosa). Qualitative and quantitative phytochemical screenings conducted for both extracts revealed the presence of alkaloids, glycosides, saponins, steroids, and triterpenoids, fat and oils, flavonoids, phenols, and tannins in varying amounts. Both crude extracts exhibited antitrypanosomal potentials with an IC50 of 6.6/9.7 μg/mL and antiplasmodial activities with an IC50 of 8.4/13.0 μg/mL. Conclusion from this study indicates that apart from the folkloric uses of this plant in traditional settings, the extracts possess a broad spectrum of antimicrobial, antitrypanosomal, and antimalarial activities and some pharmaceutically essential bioactive components with remarkable antioxidant capacities that may be used in the synthesis of novel drugs for the management of different varieties of ailments.

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Section: Resultsmentioning

confidence: 58%

Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus

Larayetan

Ololade

Ogunmola³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…According to Cerdeiras et al [15] and Simirgiotis et al [38], the stearic acid glycoside and the 20 S, 24 R-epoxy-3a-acetoxy-1b, 12 b, 25-trihydroxydammarane were responsible for the antibacterial activity of the extract against a group of bacterial isolates.…”

Section: Concentration Of I Luteamentioning

confidence: 95%

“…In an earlier study, the antimicrobial activity of the aqueous and ethanolic extracts of I. lutea was assessed and the aqueous extract showed activity against some Gram positive and negative pathogens determined by an agar-diffusion method [6]. Several extracts (H 2 O, EtOH:H 2 O 70:30, EtOH, CH 2 Cl 2 :MeOH 3:1, acetone and CHCl 3 ) of I. lutea aerial parts were tested for antibacterial activity and it was concluded that the most active was the chloroformic one [15]. According to these authors, the extract was active against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation

Sosa

Zunino

2009

J Infect Dev Ctries

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Background: Proteus mirabilis, an important uropathogen that can cause complicated urinary tract infections (UTI), has emerged as a therapeutic problem following mutations that compromise the use of antimicrobial drugs. Due to the serious effects associated with uropathogenic P. mirabilis and the problems related to the use of antibiotics, it is necessary to develop alternative strategies for its control. The objective of this study was to assess the effect of Ibicella lutea extract, a South American indigenous plant, on growth, virulence and biofilm production of uropathogenic P. mirabilis. Methodology: This study was based on the extract generation and the assessment of its effect on bacterial features related to virulence. These assays involved determination of antibacterial activity, swarming motility, Western blot to assess expression of fimbriae and flagella, biofilms formation, haemagglutination, haemolysis, and electron microscopy. Results and Conclusions: I. lutea extract had an effect on bacterial growth rate and bacterial morphology. It also affected P. mirabilis swarming differentiation, hemagglutination and biofilm formation on glass and polystyrene. These findings suggest that I. lutea may have a role as an agent for the control of P. mirabilis UTI.

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“…A partir de l'extrait chloroformique d'Ibicella lutea, le composé antibactérien principal a été isolé et identifié par plusieurs méthodes MS et RMN en tant que nouveau composé (Cerdeiras et al, 2000). L'extrait de cette plante a eu un effet sur le taux de croissance bactérien et la morphologie bactérienne.…”

Section: Intérêt éConomiqueunclassified

Découverte d’Ibicella lutea (Lindl.) Van Eselt. (Martyniaceae) en Kabylie (Béjaia, Algérie)

Rebbas¹

2020

abm

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A new antibacterial compound from Ibicella lutea

Cited by 17 publications

References 13 publications

Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus

Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus

Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation

Découverte d’Ibicella lutea (Lindl.) Van Eselt. (Martyniaceae) en Kabylie (Béjaia, Algérie)

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