A new antibacterial clerodane diterpenoid from the resinous exudate of Haplopappus uncinatus

Urzúa, Alejandro; Jara, Francisco; Tojo, Emília; Wilkens, Marcela; Mendoza, Leonora; Rezende, Marcos Caroli

doi:10.1016/j.jep.2005.09.042

Cited by 33 publications

(28 citation statements)

References 12 publications

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“…This is not surprising since lupeol (1) and many of its derivatives (Tolstikova et al, 2006). Clerodane diterpenoids are known to possess antitumoral, antibacterial and antifungal activities (Biswanath et al, 2005;Urzúa et al, 2006). Excepted for Staphylococcus aureus ATCC 25922, compound 5 was more effective than 4.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial diterpenoids and triterpenoids from the stem bark of Croton macrostachys

Téné¹,

Bl²,

Tane³

et al. 2009

International Journal of Biological and Chemical Sciences

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Antimicrobial-guided fractionation of the EtOAc extract of the stem bark of Croton macrostachys afforded five known compounds including two lupane triterpenoids, lupeol (1) and betulin (2), and three clerodane diterpenoids, floridolide A (3), hardwickic acid (4) and 12-oxo-hardwickic acid (5). Their structures were elucidated on the basis of spectral studies and comparison with published data. The EtOAc extract and compounds 1, 2, 4 and 5 were evaluated for their antibacterial and antifungal activities by macro-dilution method. The extract displayed significant antibacterial and antifungal activities (MIC = 31.25-1000 µg/ml). Betulin (2) and 12-oxo-hardwickic acid (5) were the most active compounds (MIC = 7.81-500 µg/ml). The most sensitive microorganisms were Staphylococcus aureus ATCC 25922 for bacteria and two Candida species, Candida albicans ATCC 24433 and Candida krusei ATCC 6258, for fungi. The isolation of these active antibacterial and antifungal principles supports the use of C. macrostachys in traditional medicine for the treatment of microbial infections.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial diterpenoids and triterpenoids from the stem bark of Croton macrostachys

Téné¹,

Bl²,

Tane³

et al. 2009

International Journal of Biological and Chemical Sciences

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“…This is the case with Lomatia hirsuta (Simonsen et al, 2006), two Baccharis species (Simonsen et al, 2009), four Pseudognaphalium speices (Mendoza et al, 1997), and nine Haplopappus species (Urzúa et al, 2006(Urzúa et al, , 1995. Buddleja globosa was recently reported to have a slight effect on proliferation of fibroblasts, but it was not significant, and at higher concentrations it seemed to be cytotoxic (Houghton et al, 2005;Mensah et al, 2001).…”

Section: Familymentioning

confidence: 99%

Antimicrobial evaluation of Huilliche plant medicine used to treat wounds

Mølgaard

Holler

Asar

et al. 2011

Journal of Ethnopharmacology

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“…Double layers agar of ZoBell agar medium was used for this susceptibility test (Horikawa et al 1999;Isnansetyo and Kamei 2005;Urzúa et al 2006). Melted ZoBell medium with 0.7% agar kept in a water bath at 50°C was inoculated with a 24 h-culture of strain S2V2 in ZoBell broth medium, to give an initial bacterial density of 10 6 cells ml -1 , and overlaid onto ZoBell plate.…”

Section: Susceptibility Test To Antibioticsmentioning

confidence: 99%

A potential bacterial biocontrol agent, strain S2V2 against pathogenic marine Vibrio in aquaculture

Isnansetyo

Istiqomah

Muhtadi

et al. 2009

World J Microbiol Biotechnol

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We isolated a marine bacterium strain S2V2 which inhibited the growth of pathogenic marine Vibrio spp. The aims of this research were to identify a new antibioticproducing marine bacterium strain S2V2, and evaluate its spectrum activity and pathogenic property. Analysis of 16S rDNA sequence placed strain S2V2 in the genus Pseudoalteromonas, but the sequence similarity was low (95.46%) implying the strain might be a new species in this genus. Strain S2V2 inhibited the growth of 67.9% of 28 Vibrio strains tested. This strain inhibited V. alginolyticus, V. anguillarum, V. fluvialis, V. harveyi, V. metschnikovii, V. splendidus, V. ordalii, V. parahaemolyticus, and V. vulnificus, but inactive against V. campbellii, Aeromonas hydrophyla and Staphylococcus aureus. Strain S2V2 produced extracellular non proteinaceous antibacterial substances. The highest antibacterial activity was found when strain S2V2 was cultured for 96 h in ZoBell broth medium. An artificial infection to post larvae of Lithopenaeus vanname indicated that strain S2V2 was a non pathogenic bacterium. Non pathogenic property and specific antibacterial activity against a broad range of fish pathogenic marine Vibrio of strain S2V2 suggest that this strain is a prospective source of unique antibiotic and a potential biocontrol agent in marine aquaculture.

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A new antibacterial clerodane diterpenoid from the resinous exudate of Haplopappus uncinatus

Cited by 33 publications

References 12 publications

Antimicrobial diterpenoids and triterpenoids from the stem bark of Croton macrostachys

Antimicrobial diterpenoids and triterpenoids from the stem bark of Croton macrostachys

Antimicrobial evaluation of Huilliche plant medicine used to treat wounds

A potential bacterial biocontrol agent, strain S2V2 against pathogenic marine Vibrio in aquaculture

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