A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption

Bortolin, Rafael Calixto; Vargas, Amanda Rodrigues de; Gasparotto, Juciano; Chaves, Paula dos Santos; Schnorr, Carlos Eduardo; Martinello, Kátia da Boit; Silveira, Alexandre Kleber; Rabelo, Thallita Kelly; Gelain, Daniel Pens; Moreira, Julia

doi:10.1038/ijo.2017.225

Cited by 170 publications

(173 citation statements)

References 40 publications

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“…The HFHF diet group also showed a higher degree of steatosis than the HF diet group [168]. In a recent study, an HF sucrose pellet diet was administered to rats for 16 weeks, inducing significantly more pronounced steatosis, an increase in liver triglycerides and obesity compared to a pure HF diet treatment [169]. Surprisingly, the HF diet group in this study showed no increase in body weight or white fat deposits compared to the control diet group.…”

Section: Western Dietscontrasting

confidence: 52%

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

et al. 2019

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Nonalcoholic fatty liver disease (NAFLD) is a common disease in Western society and ranges from steatosis to steatohepatitis to end-stage liver disease such as cirrhosis and hepatocellular carcinoma. The molecular mechanisms that are involved in the progression of steatosis to more severe liver damage in patients are not fully understood. A deeper investigation of NAFLD pathogenesis is possible due to the many different animal models developed recently. In this review, we present a comparative overview of the most common dietary NAFLD rodent models with respect to their metabolic phenotype and morphological manifestation. Moreover, we describe similarities and controversies concerning the effect of NAFLD-inducing diets on mitochondria as well as mitochondria-derived oxidative stress in the progression of NAFLD.

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Section: Western Dietscontrasting

confidence: 52%

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

et al. 2019

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“…The aim of this study was to investigate whether weight loss improves the integrity of the DNA, which plays an important role in the etiology of various diseases that are associated with increased body mass (e.g., cancer, infertility, cognitive dysfunctions). Weight reduction was either achieved via restricted consumption of a Western diet (by 40%), which reflects the uptake of macronutrients in industrialized Western countries, [39] or by feeding an HCLP chow.…”

Section: Discussionmentioning

confidence: 99%

Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage

Setayesh

Mišík

Langie

et al. 2019

Molecular Nutrition Food Res

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Scope Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material. Methods and Results Overweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage (“comet” formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses indicate that the reduction of DNA damage is associated with a decrease of pro‐inflammatory cytokines and lower insulin levels. Conclusion The study indicates that weight loss may prevent obesity‐associated adverse health effects due to reduction of overall DNA damage.

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“…Diet-induced obesity has been modeled in mammals by supplementing diet with refined carbohydrates and fats (Levin et al 1989;Buettner et al 2007;Bortolin et al 2018). These studies have shown that diets high in fat and carbohydrates are capable of producing obesity in rat and mouse models with similar pathology to human obesity and produce associated comorbidities and metabolic syndromes.…”

Section: Discussionmentioning

confidence: 99%

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

et al. 2020

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Obesity and its comorbidities are a growing health epidemic. Interactions between genetic background, the environment, and behavior (i.e., diet) greatly influence organismal energy balance. Previously, we described obesogenic mutations in the gene Split ends (Spen) in Drosophila melanogaster, and roles for Spen in fat storage and metabolic state. Lipid catabolism is impaired in Spen-deficient fat storage cells, accompanied by a compensatory increase in glycolytic flux and protein catabolism. Here, we investigate gene–diet interactions to determine if diets supplemented with specific macronutrients can rescue metabolic dysfunction in Spen-depleted animals. We show that a high-yeast diet partially rescues adiposity and developmental defects. High sugar partially improves developmental timing as well as longevity of mated females. Gene–diet interactions were heavily influenced by developmental-stage-specific organismal needs: extra yeast provides benefits early in development (larval stages) but becomes detrimental in adulthood. High sugar confers benefits to Spen-depleted animals at both larval and adult stages, with the caveat of increased adiposity. A high-fat diet is detrimental according to all tested criteria, regardless of genotype. Whereas Spen depletion influenced phenotypic responses to supplemented diets, diet was the dominant factor in directing the whole-organism steady-state metabolome. Obesity is a complex disease of genetic, environmental, and behavioral inputs. Our results show that diet customization can ameliorate metabolic dysfunction underpinned by a genetic factor.

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A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption

Cited by 170 publications

References 40 publications

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage

Gene–Diet Interactions: Dietary Rescue of Metabolic Defects in spen-Depleted Drosophila melanogaster

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