A New Angle-Independent Doppler Ultrasonic Device for Assessment of Blood Flow Volume in the Extracranial Internal Carotid Artery

Soustiel, Jean F.; Levy, Eli; Zaaroor, Menashe; Bibi, Roni; Lukaschuk, Sergei; Manor, David

doi:10.7863/jum.2002.21.12.1405

Cited by 34 publications

(29 citation statements)

References 29 publications

(31 reference statements)

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“…140 -143 These requirements are achieved, for instance, with the Quantix-ND system (CardiosonixNeoprobe), which uses pulse-wave digital Doppler to integrate with high-resolution temporal and spatial variations commonly overlooked by duplex imaging. 141,143 Interpretation Angle-independent dual-beam flow is based on the simultaneous use of 2 ultrasound beams with a known geometrical configuration. Using dedicated digital Doppler technology, hundreds of sample volumes of Ͻ200 m in length at successive depths are simultaneously sampled along each ultrasound beam.…”

Section: Technical Requirementsmentioning

confidence: 99%

“…Because the angle between the 2 beams is known, the insonation angles of the 2 beams can be drawn from simple calculation based on trigonometric and Doppler considerations. 143 Further process- Graphic user interface of a computer system after a typical ICA BFV measurement. Along with flow data, spectra of both channels (spectrum A and spectrum B) with corresponding flow velocities (Flow) and diameters (Da and Db) are displayed to assess during the test and thereafter the adequate alignment of the ultrasound beam along the vessel axis, which represents a critical condition for accurate measurements.…”

Section: Technical Requirementsmentioning

confidence: 99%

“…Accordingly, focal CBF impairments confined to a rather small area or secondary to single vessel pathology may be masked by a remaining and otherwise preserved hemispheric flow. 143 …”

Section: Feasibilitymentioning

confidence: 99%

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Comparative Overview of Brain Perfusion Imaging Techniques

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et al. 2005

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420

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Background and Purpose-Numerous imaging techniques have been developed and applied to evaluate brain hemodynamics. Among these are positron emission tomography, single photon emission computed tomography, Xenonenhanced computed tomography, dynamic perfusion computed tomography, MRI dynamic susceptibility contrast, arterial spin labeling, and Doppler ultrasound. These techniques give similar information about brain hemodynamics in the form of parameters such as cerebral blood flow or cerebral blood volume. All of them are used to characterize the same types of pathological conditions. However, each technique has its own advantages and drawbacks. Summary of Review-This

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Section: Technical Requirementsmentioning

confidence: 99%

Section: Technical Requirementsmentioning

confidence: 99%

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Comparative Overview of Brain Perfusion Imaging Techniques

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Sesay

Barbier

et al. 2005

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“…Patients were studied in a semidarkened room after resting for 10 min. Blood flow in both ICAs was measured with an angle-independent dual-beam flow (ADBF) Doppler system (Quantix ND, Cardiosonix) as described by Soustiel et al (35). Briefly, ADBF is based on simultaneous interrogation of two ultrasound beams with known geometric configuration.…”

Section: Methodsmentioning

confidence: 99%

Cerebral blood flow is increased during controlled ovarian stimulation

Nevo¹,

Soustiel²,

Thaler³

2007

American Journal of Physiology-Heart and Circulatory Physiology

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Estrogen appears to enhance cerebral blood flow (CBF). An association between CBF and physiologically altered hormonal levels due to menstrual cycle, menopause, or exogenous manipulations such as ovariectomy or hormone replacement therapy has been demonstrated. The purpose of this study was to determine the association between ovarian stimulation and CBF in vivo by measuring blood flow in the internal carotid artery (ICA) after pituitary suppression and during controlled ovarian stimulation in women undergoing in vitro fertilization treatment cycles. ICA volume flows were measured by angle-independent dual-beam ultrasound Doppler in 12 women undergoing controlled ovarian stimulation. Measurements were performed after pituitary/ovarian suppression, in the late follicular phase, and at midluteal phase. Blood flow in the ICA increased by 22.2% and 32% in the late follicular and midluteal phases compared with the respective values obtained during ovarian suppression (P Ͻ 0.0005 and P Ͻ 0.0001, respectively). There was a significant correlation between increments in estrogen levels and increments in CBF when the late follicular phase was compared with the ovarian suppression period (r ϭ 0.8, P Ͻ 0.001). Mean blood flow velocity significantly increased (by 15.7% and 16.9%, respectively) and cerebral vascular resistance significantly decreased (by 17.6% and 26.5%) during the late follicular and midluteal phases compared with respective measures during ovarian suppression. There was a significant correlation between an increase in estrogen levels and a decrease in cerebral vascular resistance when the late follicular phase was compared with the ovarian suppression period (r ϭ Ϫ0.6, P Ͻ 0.05). These changes imply sex hormone-associated intracranial vasodilation leading to increased CBF during controlled ovarian stimulation.estrogen; progesterone; angle-independent Doppler; in vitro fertilization RECENT REPORTS HAVE SUGGESTED that the cerebral circulation may be affected by hormonal status. Increased cerebral blood flow (CBF) velocities were observed in the presence of high levels of estradiol (3,25). Progesterone was shown to increase peripheral blood flow in pigs (24) and to have neuroprotective properties in male rats (12). However, there is little information regarding the effect of estrogen and progesterone on CBF in human subjects.During controlled ovarian stimulation that is utilized for in vitro fertilization (IVF) treatment cycles, there is a significant increase in serum estradiol levels during the hyperstimulated follicular phase and the luteal phase (13). The source of estrogen during an IVF cycle is the hyperstimulated follicles in the follicular phase and the corpora lutea during the luteal phase. Progesterone levels start to increase after the induction of final oocyte maturation by human chorionic gonadotropin (hCG), and supraphysiological levels are encountered during the luteal phase (11). Progesterone is secreted during the luteal phase from multiple corpora lutea that develop after trigger of oocyte ma...

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“…A recent report has suggested the implementation of digital Doppler ultrasound and angle-independent dual-beam technology for improvement of accuracy in the assessment of hemispheric CBF. 5 The aim of the present study was to evaluate this novel ultrasound device by means of the 133 xenon-clearance technique.…”

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confidence: 99%

Assessment of Cerebral Blood Flow by Means of Blood-Flow-Volume Measurement in the Internal Carotid Artery

Soustiel

Glenn

Vespa

et al. 2003

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Background and Purpose-We sought to evaluate a new, angle-independent ultrasonic device for assessment of blood flow volume (BFV) in the internal carotid artery (ICA). Methods-Nineteen patients and 4 healthy volunteers were enrolled in a comparative study conducted in the Care Unit of the Division of Neurosurgery at UCLA Medical Center. All patients had been admitted because of severe brain injury: 15 patients with severe head trauma (Glasgow Coma Scale scoreՅ8) and 4 patients with subarachnoid hemorrhage due to aneurysm rupture. In all patients and subjects, cerebral blood flow (CBF) values obtained with the 133 xenon-clearance technique were compared with BFV measurements in the ipsilateral ICA. Results-Hemispheric CBF values showed a close and linear correlation with BFV measurements (rϭ0.76, PϽ0.0001).Global CBF values showed a higher correlation with the total BFV value obtained from both ICAs (rϭ0.84, PϽ0.0001). With 37 mL · min Ϫ1 · 100 g Ϫ1 as a cutoff value for the ischemic range, a BFV value of 220 mL/min would yield a positive predictive value of 91.7% and a negative predictive value of 82.6% (sensitivity 73.3%, specificity 95%). Conversely, BFV sensitivity and specificity were 60% and 96%, respectively, for the hyperemic range defined by a CBF value Ͼ55 mL · min Ϫ1 · 100 g Ϫ1 (positive predictive value of 85.7% and negative prediction value of 85.7%). Conclusions-BFV

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A New Angle-Independent Doppler Ultrasonic Device for Assessment of Blood Flow Volume in the Extracranial Internal Carotid Artery

Cited by 34 publications

References 29 publications

Comparative Overview of Brain Perfusion Imaging Techniques

Comparative Overview of Brain Perfusion Imaging Techniques

Cerebral blood flow is increased during controlled ovarian stimulation

Assessment of Cerebral Blood Flow by Means of Blood-Flow-Volume Measurement in the Internal Carotid Artery

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