A new and simple parameter for diagnosis pulmonary edema: Expiratory air humidity

Adar, Adem; Can, Emine Yılmaz; Elma, Yusuf; Ferah, Meryem Akpolat; Kececi, Mete; Müderrisoğlu, Haldun; Akbay, Ertan; Akıncı, Si̇nan; Çoner, Ali; Haberal, Cevahir; Cakan, Fahri; Özer, Orhan

doi:10.1016/j.hrtlng.2022.01.009

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…It was proposed that humidity in the exhaled air was significantly lower in rats developing acute pulmonary edema (induced by a-naphthylthiourea) compared to healthy rats. The result supports the hypothesis that humidity in expiratory air can be considered an important parameter to follow-up pulmonary edema in patients (Adar et al 2022 ). S ee PROPOSAL 3.…”

Section: Data That Are Consistent With But Not Proof Of Interstitial ...supporting

confidence: 89%

A century of exercise physiology: lung fluid balance during and following exercise

Miserocchi

Beretta

2022

Eur J Appl Physiol

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Purpose This review recalls the principles developed over a century to describe trans-capillary fluid exchanges concerning in particular the lung during exercise, a specific condition where dyspnea is a leading symptom, the question being whether this symptom simply relates to fatigue or also implies some degree of lung edema. Method Data from experimental models of lung edema are recalled aiming to: (1) describe how extravascular lung water is strictly controlled by “safety factors” in physiological conditions, (2) consider how waning of “safety factors” inevitably leads to development of lung edema, (3) correlate data from experimental models with data from exercising humans. Results Exercise is a strong edemagenic condition as the increase in cardiac output leads to lung capillary recruitment, increase in capillary surface for fluid exchange and potential increase in capillary pressure. The physiological low microvascular permeability may be impaired by conditions causing damage to the interstitial matrix macromolecular assembly leading to alveolar edema and haemorrhage. These conditions include hypoxia, cyclic alveolar unfolding/folding during hyperventilation putting a tensile stress on septa, intensity and duration of exercise as well as inter-individual proneness to develop lung edema. Conclusion Data from exercising humans showed inter-individual differences in the dispersion of the lung ventilation/perfusion ratio and increase in oxygen alveolar-capillary gradient. More recent data in humans support the hypothesis that greater vasoconstriction, pulmonary hypertension and slower kinetics of alveolar-capillary O2 equilibration relate with greater proneness to develop lung edema due higher inborn microvascular permeability possibly reflecting the morpho-functional features of the air–blood barrier.

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Section: Data That Are Consistent With But Not Proof Of Interstitial ...supporting

confidence: 89%

A century of exercise physiology: lung fluid balance during and following exercise

Miserocchi

Beretta

2022

Eur J Appl Physiol

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“…[40] Additionally, chrysin has demonstrated gastrointestinal protective properties in cases of colitis, inflammatory bowel disease, diarrhea, and gastric ulcers. [41] In terms of the respiratory tract, chrysin has demon-strated protective effects for the respiratory tract against pneumonia, asthma, lung fibrosis, pulmonary edema, pulmonary arterial hypertension, and allergic inflammation as well as pulmonary hypertension, pleurisy, and lung injury [42,43] Additionally, endometriosis, early ovarian failure, ovarian torsion, reproductive toxicity, and benign prostate hyperplasia have all been linked to chrysin's protective effects on the reproductive system. [33] In diseases such diabetic retinopathy, cataracts, agerelated macular degeneration, and uveitis, chysin has demonstrated ocular protective properties.…”

Section: Biological Activities Of Chrysinmentioning

confidence: 99%

Chrysin, The Flavonoid Molecule of Antioxidant Interest

Mohammed,

Sulaiman,

Albukhaty

et al. 2023

ChemistrySelect

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Chrysin, the natural bioactive flavone compound, has been identified in several edible materials such as honey, propolis, and passionflower with numerous biological potentials and pharmaceutical effects including antitumor, anti‐inflammatory, antiviral and antioxidant. The compound has been reported to have lower in vitro antioxidant activity compared to other flavone‐based structures such as quercetin, luteolin, and myricetin, which is mostly attributed to the higher hydroxylation and the presence of conjugated en‐diol structures in these flavonoids and the lack of these structural features in chrysin. On the contrary to the in vitro antioxidant effect of chrysin, the compound has exerted remarkable in vivo antioxidant activities in several models related to the liver, brain, heart, kidneys, and other soft tissues. The current review includes a discussion of the in vivo and in vitro antioxidant activity of chrysin compared to other common flavonoids. The study also covers subjects linked to chrysin antioxidants, such as its metabolism, bioavailability, and current formulations that aim to increase chrysin antioxidant impact and overcome its low bioavailability.

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“…Valid help would come from an in vivo estimate of vascular permeability [ 65 ]. It is of interest to recall the recently proposed methods allowing to relate the time course of edema based on water evaporation from exhaled air [ 66 ].…”

Section: Conclusion and Summary Of Unknown Points To Be Addressed In ...mentioning

confidence: 99%

Early Endothelial Signaling Transduction in Developing Lung Edema

Miserocchi

2023

Life

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The lung promptly responds to edemagenic conditions through functional adaptations that contrast the increase in microvascular filtration. This review presents evidence for early signaling transduction by endothelial lung cells in two experimental animal models of edema, hypoxia exposure, and fluid overload (hydraulic edema). The potential role of specialized sites of the plasma membranes considered mobile signaling platforms, referred to as membrane rafts, that include caveolae and lipid rafts, is presented. The hypothesis is put forward that early changes in the lipid composition of the bilayer of the plasma membrane might trigger the signal transduction process when facing changes in the pericellular microenvironment caused by edema. Evidence is provided that for an increase in the extravascular lung water volume not exceeding 10%, changes in the composition of the plasma membrane of endothelial cells are evoked in response to mechanical stimuli from the interstitial compartment as well as chemical stimuli relating with changes in the concentration of the disassembled portions of structural macromolecules. In hypoxia, thinning of endothelial cells, a decrease in caveolae and AQP-1, and an increase in lipid rafts are observed. The interpretation of this response is that it favors oxygen diffusion and hinder trans-cellular water fluxes. In hydraulic edema, which generates greater capillary water leakages, an increase in cell volume and opposite changes in membrane rafts were observed; further, the remarkable increase in caveolae suggests a potential abluminal–luminal vesicular-dependent fluid reabsorption.

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A new and simple parameter for diagnosis pulmonary edema: Expiratory air humidity

Cited by 5 publications

References 14 publications

A century of exercise physiology: lung fluid balance during and following exercise

A century of exercise physiology: lung fluid balance during and following exercise

Chrysin, The Flavonoid Molecule of Antioxidant Interest

Early Endothelial Signaling Transduction in Developing Lung Edema

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