A new amino acid, hybrid peptides and BODIPY analogs: synthesis and evaluation of 2-aminotroponyl-l-alanine (ATA) derivatives

Abstract

Natural aromatic α-amino acid residues play critical roles in the structural and functional organization of proteins owing to the π-interactions. Their aromatic residues are derived from the benzenoid scaffolds. The...

Synthesis of N-isoindolinonyl peptides via Pd-catalyzed C(sp2)–H olefination–activation and their conformational studies

“…These peptides were subjected to Pd-catalyzed C–H activation/olefination reactions with different olefins by using our previously reported method. 56 Unfortunately, we could not obtain any olefinated/activated product. We noticed the formation of isoindolinonyl peptides ( 8a ) from peptide 6a and olefin methyl acrylate ( 7a ) under Cu(OAc) 2 /NaOAc at 100 °C in the presence of Pd catalyst.…”