Abstract:Natural aromatic α-amino acid residues play critical roles in the structural and functional organization of proteins owing to the π-interactions. Their aromatic residues are derived from the benzenoid scaffolds. The...
“…These peptides were subjected to Pd-catalyzed C–H activation/olefination reactions with different olefins by using our previously reported method. 56 Unfortunately, we could not obtain any olefinated/activated product. We noticed the formation of isoindolinonyl peptides ( 8a ) from peptide 6a and olefin methyl acrylate ( 7a ) under Cu(OAc) 2 /NaOAc at 100 °C in the presence of Pd catalyst.…”
Isoindolinone is a constituent of several natural products that show wide range of bioactivities such as anticancer, antimicrobial, antiviral and anti-inflamatory properties. It would be interesting to explore the isoindolinone’s...
“…These peptides were subjected to Pd-catalyzed C–H activation/olefination reactions with different olefins by using our previously reported method. 56 Unfortunately, we could not obtain any olefinated/activated product. We noticed the formation of isoindolinonyl peptides ( 8a ) from peptide 6a and olefin methyl acrylate ( 7a ) under Cu(OAc) 2 /NaOAc at 100 °C in the presence of Pd catalyst.…”
Isoindolinone is a constituent of several natural products that show wide range of bioactivities such as anticancer, antimicrobial, antiviral and anti-inflamatory properties. It would be interesting to explore the isoindolinone’s...
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