A new allergen family involved in pollen food-associated syndrome: Snakin/gibberellin-regulated proteins

Identification of gibberellin‐regulated protein as a new allergen in orange allergy

“…The conformation or proper exposure of peptidic epitopes in glycoproteins is also frequently modulated by glycosylation mediated by intramolecular carbohydrate‐protein interactions. In addition, a recent French study showed that a protein with a molecular weight of 14 kDa from cypress pollen was allergenic and cross‐reactive with fruit‐ and vegetable‐originated GRPs, as determined with an immunoblotting inhibition assay …”

“…In addition, a recent French study showed that a protein with a molecular weight of 14 kDa from cypress pollen was allergenic and cross-reactive with fruit-and vegetable-originated GRPs, as determined with an immunoblotting inhibition assay. 27 To date, searches of all databases available in the U.S. National…”

The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross‐reactive gibberellin‐regulated protein in cypress pollen: BP14

“…Snakin-1 is 82% identical to Pru p 7 (and not necessarily homologous) and has been used as a surrogate of peamaclein in the JACI paper (reference #38 of the CEA paper). 6 None of the BP14+ cypress pollen-allergic patients tested was allergic to potato (table S1 in Ref. 6 ) but IgE cross-reactivities with snakin-1 were readily observed.…”

“…6 None of the BP14+ cypress pollen-allergic patients tested was allergic to potato (table S1 in Ref. 6 ) but IgE cross-reactivities with snakin-1 were readily observed. Crossed inhibition experiments with BP14 (not a total cypress pollen extract but the isolated allergen itself) showed a partial cross-reactivity with snakin-1 6 and a total crossreactivity with Pru p 7.…”

“…3 Like Pru p 7, BP14 is a member of the GRP family. The results of cross-reactivity were published in three scientific papers [4][5][6] and mentioned in two reviews, one in English 7 and one in French. 8 The scientific paper in French in Rev Fr Allergol was, in fact, a response to a paper published in the same journal by Klingebiel et al 9 (reference #16 in CEA paper).…”