A new alkaloid and two organic acids from
            <i>Portulaca oleracea</i>
            L. and their bioactivities

Liu, Peishan; Lan, Xiujuan; Tao, Xiaojun; Tian, Jiayin; Ying, Xixiang; Stien, Didier

doi:10.1080/14786419.2022.2103696

Cited by 7 publications

(2 citation statements)

References 48 publications

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“…Furthermore, in the present work, we found that one alkaloid PT22 (1H-pyrrole-2,5-dicarboxylic acid) from the endophytic fungus P. tephropora FF2 isolated from A. catechu L. could inhibit the quorum sensing signaling molecules, virulence factor production, biofilm formation, motility and expression of QS-related genes, and function as an antibiotic accelerant against P. aeruginosa PAO1 infection. A previous study suggested that PT22 could inhibit IL-1β and TNF-α at 10 μM and 20 μM, respectively ( Liu et al., 2024 ). This is the first report for PT22 as a QSI isolated from A. catechu L. endophytic fungus.…”

Section: Discussionmentioning

confidence: 97%

1H-Pyrrole-2,5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas aeruginosa

Liu,

Wang,

Zeng

et al. 2024

Front. Cell. Infect. Microbiol.

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Pseudomonas aeruginosa has already been stipulated as a “critical” pathogen, emphasizing the urgent need for researching and developing novel antibacterial agents due to multidrug resistance. Bacterial biofilm formation facilitates cystic fibrosis development and restricts the antibacterial potential of many current antibiotics. The capacity of P. aeruginosa to form biofilms and resist antibiotics is closely correlated with quorum sensing (QS). Bacterial QS is being contemplated as a promising target for developing novel antibacterial agents. QS inhibitors are a promising strategy for treating chronic infections. This study reported that the active compound PT22 (1H-pyrrole-2,5-dicarboxylic acid) isolated from Perenniporia tephropora FF2, one endophytic fungus from Areca catechu L., presents QS inhibitory activity against P. aeruginosa. Combined with gentamycin or piperacillin, PT22 functions as a novel antibiotic accelerant against P. aeruginosa. PT22 (0.50 mg/mL, 0.75 mg/mL, and 1.00 mg/mL) reduces the production of QS-related virulence factors, such as pyocyanin and rhamnolipid, and inhibits biofilm formation of P. aeruginosa PAO1 instead of affecting its growth. The architectural disruption of the biofilms was confirmed by visualization through scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Real-time quantitative PCR (RT-qPCR) indicated that PT22 significantly attenuated the expression of QS-related genes followed by docking analysis of molecules against QS activator proteins. PT22 dramatically increased the survival rate of Galleria mellonella. PT22 combined with gentamycin or piperacillin presents significant inhibition of biofilm formation and eradication of mature biofilm compared to monotherapy, which was also confirmed by visualization through SEM and CLSM. After being treated with PT22 combined with gentamycin or piperacillin, the survival rates of G. mellonella were significantly increased compared to those of monotherapy. PT22 significantly enhanced the susceptibility of gentamycin and piperacillin against P. aeruginosa PAO1. Our results suggest that PT22 from P. tephropora FF2 as a potent QS inhibitor is a candidate antibiotic accelerant to combat the antibiotic resistance of P. aeruginosa.

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Section: Discussionmentioning

confidence: 97%

1H-Pyrrole-2,5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas aeruginosa

Liu,

Wang,

Zeng

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Several new compounds with bioactive potential have been isolated from purslane during recent years, indicating the high antioxidant potential of the species. For example, new alkaloids with anti-inflammatory activity were identified in various studies [ 128 , 129 , 130 , 131 , 132 ], while Wang et al [ 133 ] detected two new lignans with similar properties. These novel compounds could be isolated and incorporated in the design of new drug formulations, nutraceutical and pharmaceutical products, thus increasing the added value of purslane.…”

Section: Future Prospects and Conclusionary Remarksmentioning

confidence: 99%

Agronomical Practices and Management for Commercial Cultivation of Portulaca oleracea as a Crop: A Review

Carrascosa

Pascual

Ros

et al. 2023

Plants

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Soil is an essential resource, and its degradation is challenging modern agriculture, while its impact is expected to increase in the near future. One of the strategies to address this issue is to incorporate new alternative crops able to tolerate arduous conditions, as well as for the use of sustainable agricultural practices in order to recover and/or improve soil health. Additionally, the increasing market for new functional/healthy natural foods promotes the search for potential alternative crop species with promising bioactive compounds content. For this purpose, wild edible plants are a key option because they have already been consumed for hundreds of years in traditional gastronomy and there is well-established evidence of their health-promoting effects. Moreover, since they are not a cultivated species, they are able to grow under natural conditions without human intervention. Among them, common purslane is an interesting wild edible species and a good candidate for integration in commercial farming systems. With worldwide spread, it is able to tolerate drought, salinity and heat stress and is already used in traditional dishes, while it is highly appreciated for its high nutritional value due to its bioactive compound content, especially omega-3 fatty acids. In this review, we aim to present the breeding and cultivation practices of purslane, as well as the effects of abiotic stressors on yield and chemical composition of the edible parts. Finally, we present information that helps to optimize purslane cultivation and facilitate its management in degraded soils for their exploitation in the existing farming systems.

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The molecular basis of the immunomodulatory effects of natural products: A comprehensive review

Beigoli,

Boskabady

2024

Phytomedicine

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A new alkaloid and two organic acids from Portulaca oleracea L. and their bioactivities

Cited by 7 publications

References 48 publications

1H-Pyrrole-2,5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas aeruginosa

1H-Pyrrole-2,5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas aeruginosa

Agronomical Practices and Management for Commercial Cultivation of Portulaca oleracea as a Crop: A Review

The molecular basis of the immunomodulatory effects of natural products: A comprehensive review

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