Abstract.A ventricular septal defect (VSD) is the most common congenital heart disease, which can be cured with a high probability if it is detected in an early stage. In our previous researches on heart sounds (HSs) analysis, the detection methods of heart disease using the cardiac sound characteristic waveforms in time domain or in frequency domain were proposed, and have been succeed in discriminating several heart murmurs. In this paper, we are going to apply these methods to detect VSD. Based on analysis results, a new approach by using the feature parameters both in time domain and in frequency domain is proposed to achieve higher discrimination rates.