A new Ag-nanostructured hydroxyapatite porous scaffold: Antibacterial effect and cytotoxicity study

Calabrese, Giovanna; Petralia, Salvatore; Franco, Domenico; Nocito, Giuseppe; Fabbi, Claudia; Forte, Lucia; Guglielmino, Salvatore; Squarzoni, Stefano; Traina, Francesco; Conoci, Sabrina

doi:10.1016/j.msec.2020.111394

Cited by 65 publications

(52 citation statements)

References 47 publications

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“…Moreover, the development of multifunctional polymer-based nanocomposites exhibiting several functionalities combined in a single device is one of the most favorable approaches to reach new smart materials [ 22 , 23 , 24 ]. In this perspective, silver nanoparticles (Ag NPs) are considered one of the most promising candidates in biomedical applications thanks to their multiple functions [ 25 , 26 ]. In addition, recent research has shown promising results for their innovative and potential applications in the food field, which also include their integration into intelligent food packaging systems and their direct incorporation into food matrices as a flavor carrier system [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

et al. 2021

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Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment such as antibiotic resistances or low drug selectivity and toxicity during systemic applications. Some functional hybrid nanomaterials are designed to handle the drug release process under remote-control. More attention has recently been paid to synthetic polyelectrolytes for their intrinsic properties which allow them to rearrange into compact structures, ideal to be used as drug carriers or probes influencing biochemical processes. The presence of Ag nanoparticles (NPs) in the Poly methyl acrylate (PMA) matrix leads to an enhancement of drug release efficiency, even using a low-power laser whose wavelength is far from the Ag Surface Plasmon Resonance (SPR) peak. Further, compared to the colloids, the nanofiber-based drug delivery system has shown shorter response time and more precise control over the release rate. The efficiency and timing of involved drug release mechanisms has been estimated by the Weibull distribution function, whose parameters indicate that the release mechanism of nanofibers obeys Fick’s first law while a non-Fickian character controlled by diffusion and relaxation of polymer chains occurs in the colloidal phase.

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Section: Introductionmentioning

confidence: 99%

Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

et al. 2021

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“…They are structures ranging from 1 to 100 nm in size that give rise to peculiar physical-chemical properties distinguished for many purposes. In the biomedical field, NPs are widely exploited for bioimaging [ 12 ], drug delivery systems [ 13 ], therapeutic agents for photodynamic (PDT) [ 14 ], photothermal therapy (PTT) [ 15 ], regenerative medicine [ 16 , 17 ], smart biomaterials [ 18 ], and sensing [ 19 ]. Metal nanoparticles (MNPs) are the most studied, especially noble metal NPs, including Gold (AuNPs) [ 20 ], Silver (AgNPs) [ 21 ], Platinum (PtNPs) [ 22 ] and Palladium (PdNPs) [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

Nocito

Calabrese

Forte³

et al. 2021

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Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy.

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“…HAP is a calcium phosphate with a high specific surface area, low water solubility, corrosion resistance and ion exchange capacity. HAP has mainly been used in dentistry 2 of 16 and implantology [3][4][5][6], but at the same time as the development of nano-HAP, its study as a drug carrier [7,8] has come to the forefront of research.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite and Silicon-Modified Hydroxyapatite as Drug Carriers for 4-Aminopyridine

et al. 2021

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Adsorption and desorption properties of nano-hydroxyapatite (HAP) and silicon-modified hydroxyapatite (Si–HAP) were investigated with 4-aminopyridine (fampridine-4AP). The novelty of this research is the investigation of the suitability of the previously mentioned carriers for drug-delivery of 4AP. UV-VIS spectrophotometric results showed that the presence of silicon in the carrier did not significantly affect its adsorption capacity. The success of the adsorption was confirmed by thermal analysis (TG/DTA), scanning electron microscopy (SEM)/energy dispersive X-ray (EDX), Fourier transform infrared (FTIR) spectroscopy, and X-ray powder diffraction (XRPD). Drug release experiments, performed in simulated body fluid (SBF), revealed a drug release from Si–HAP that was five times slower than HAP, explained by the good chemical bonding between the silanol groups of the carrier and the 4AP functional groups. The electrochemical measurements showed a value of the polarization resistance of the charge transfer (Rct) more than five times smaller in the case of Si–HAP coating loaded with 4AP, so the charge transfer process was hindered. The electrochemical impedance results revealed that electron transfer was inhibited in the presence of 4AP, in concordance with the previously mentioned strong bonds. The silicon substitution in HAP leads to good chemical bonding with the drug and a slow release, respectively.

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A new Ag-nanostructured hydroxyapatite porous scaffold: Antibacterial effect and cytotoxicity study

Cited by 65 publications

References 47 publications

Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

Hydroxyapatite and Silicon-Modified Hydroxyapatite as Drug Carriers for 4-Aminopyridine

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