A New Acylated Flavonol Glycoside and Antioxidant Effects of <i>Hedyotis diffusa</i>

Lu, Chai-Ming; Yang, Jeng-Fu; Wang, Phen-Yuh; Lin, Chun‐Ching

doi:10.1055/s-2000-8544

Cited by 68 publications

(44 citation statements)

References 7 publications

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“…[33] The extract protected renal tissues, significantly suppressed the production of TNF-α, IL-1, IL-6 and MCP-1, as well as significantly promoted the production of IL-10 in serum and renal tissues.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

“…Iridoids are one of the most important components in H. diffusa with various bioactivities, such as anti-oxidant, neuroprotective and anti-inflammatory effects [33,53]. Accompanied with the analysis of the NMR spectra of the pure compounds, the methods of tandem mass spectrometry (MS n ) and time-of-flight mass spectrometry (TOF/MS) have become more popular for the identification of these compounds [11,14,15,25,52].…”

Section: Iridoids and Triterpenesmentioning

confidence: 99%

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The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

et al. 2016

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Hedyotis diffusa Willd (H. diffusa) is a well-known Chinese medicine with a variety of activities, especially its anti-cancer effect in the clinic. Up to now, 171 compounds have been reported from H. diffusa, including 32 iridoids, 26 flavonoids, 24 anthraquinones, 26 phenolics and their derivatives, 50 volatile oils and 13 miscellaneous compounds. In vitro and in vivo studies show these phytochemicals and plant extracts to exhibit a range of pharmacological activities of anti-cancer, antioxidant, anti-inflammatory, anti-fibroblast, immunomodulatory and neuroprotective effects. Although a series of methods have been established for the quality control of H. diffusa, a feasible and reliable approach is still needed in consideration of its botanical origin, collecting time and bioactive effects. Meanwhile, more pharmacokinetics researches are needed to illustrate the characteristics of H. diffusa in vivo. The present review aims to provide up-to-date and comprehensive information on the phytochemistry, pharmacology, quality control and pharmacokinetic characteristics of H. diffusa for its clinical use and further development.

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Section: Antioxidant Effectsmentioning

confidence: 99%

Section: Iridoids and Triterpenesmentioning

confidence: 99%

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

et al. 2016

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“…12,13) Our results showed that inhibition of malondialdehyde (MDA) formation increases with increasing concentrations of test compounds and trolox. The peracylates 2a and 2b also showed notable inhibitory effects with IC 50 values 21.81 and 13.59 mg/ml, respectively.…”

Section: Resultsmentioning

confidence: 85%

“…1 H-NMR (400 MHz) and 13 C-NMR (100 MHz) spectra were recorded on a Varian Mercury-400 (400 MHz; Varian Inc., CA, U.S.A.) spectrometer whereas the EI-MS was taken on a TurboMass mass spectrometer and FAB-MS on a JMS-HX 110 mass spectrometer (Perkin Elmer Inc., MA, U.S.A.). Optical specific rotation was measured by Jasco model DIP-370 Digital Polarimeter (JASCO Inc, MD, U.S.A.).…”

Section: Resultsmentioning

confidence: 99%

Antioxidative Effects of 6-Methoxysorigenin and Its Derivatives from Rhamnus nakaharai

Lin

2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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Oxidative stress is well known as a major cause of various chronic diseases, namely cardiovascular diseases, rheumatism, diabetes mellitus, and cancer.1,2) Reactive oxygen species (ROS) are generated in vivo during shock, inflammation, and ischemia/reperfusion injury.3) Antioxidant therapy has been clinically demonstrated to be valuable in the prevention of certain chronic diseases. 3,4) Antioxidants also play an important role in the food industry, because excessive formation of free radicals can accelerate oxidation of lipids in foods and thereby decreases food quality.Rhamnus nakaharai HAYATA (Rhamnaceae) is traditionally used as a folk medicine in Taiwan for treating constipation, inflammation, malignant tumors, and asthma. 5) 3-O-Methyquercetin, the main constituent of the plant, has been reported to inhibit cAMP-and cGMP-phosphodiesterase activity of guinea pig trachealis.6) It was also demonstrated a selective and competitive inhibitor of phosphosdiesterase subtype 3/subtype 4. 5) Isotorachrysone (1), an acetonaphthone isolated from R. nakaharai, showed antioxidant 7) and platelet aggregation inhibitory 8) activities. 6-Methoxysorigenin (2), isolated from the wood of R. nakaharai, possesses a structure closely analogous to 1 (Fig. 1) and is rich in glycosides. 9)To evaluate the antioxidant effect of 2 and its derivatives, glycosides from the wood of R. nakaharai were isolated and characterized. They were 6-methoxysorigenin-8-O-glucoside (3), a-sorinin (4), 6-methoxysorigenin-8-O-rutinoside (5). In addition, peracylates 2a and 2b, and 2 were prepared and evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal chelating, and electron spin resonance (ESR) assays as well as FeCl 2 -ascorbic acid-induced lipid peroxidation assay in rat liver homogenates in vitro. Their antioxidant activities were compared with those of trolox and with EDTA for results of metal chelating assay. Results and DiscussionDPPH · is a stable free radical that accepts an electron or hydrogen radical to become a stable diamagnetic molecule. 10)In this assay, all test compounds effectively reduced the stable radical DPPH to the yellow-colored diphenylpicrylhydrazine and their scavenging effect was dose-dependent. It was found that compound 2 possesses the most potent DPPH radical-scavenging activity, with an IC 50 value of 3.48 mg/ml, which is close to that of trolox (IC 50 : 3.18 mg/ml) ( Table 1).Chelating agents, which form s-bonds with a metal, are effective as secondary antioxidants because they reduce the redox potential thereby stabilizing the oxidized form of the metal ion.11) Chelation may inhibit lipid oxidation by stabilizing transition metals. In this study, all test compounds including trolox and EDTA interfered with the formation of ferrous and ferrozine complexes, suggesting that they have chelating activity and are able to capture ferrous ion before ferrozine. Compound 2 (IC 50 : 615.90 mg/ml) showed a stronger iron-binding capacity than trolox (IC 50 : 1848.83 mg/ In the search for potentia...

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“…In previous studies, it was found that many Taiwanese folk herbs have pharmacological functions such as anti-inflammation, anti-virus, anti-cancer, immune enhancement, antioxidant, anti-aggregation and hepatoprotection (Chang et al, 2005;Hsu et al, 2005;Kuo et al, 2004;Lin et al, 2000Lin et al, , 2002Lin et al, , 2007Lu et al, 2000;Wu et al, 2004;Yang et al, 2005Yang et al, , 2007Yen et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperlipidemic activity of spider brake (Pteris multifida) with rats fed a high cholesterol diet

Wang¹,

Lin²,

Lee³

et al. 2009

Pharmaceutical Biology

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A New Acylated Flavonol Glycoside and Antioxidant Effects of Hedyotis diffusa

Cited by 68 publications

References 7 publications

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics

Antioxidative Effects of 6-Methoxysorigenin and Its Derivatives from Rhamnus nakaharai

Anti-hyperlipidemic activity of spider brake (Pteris multifida) with rats fed a high cholesterol diet

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