A new acorane sesquiterpenes of Lysionotus pauciflorus maxim. Form Guizhou province, China

Acorane sesquiterpenes from the deep-sea derived Penicillium bilaiae fungus with anti-neuroinflammatory effects

“…In this study, the bioinformatics approach in association with the molecular networking data provides an effective method to detect the metabolite patterns produced by marine-derived fungi, and a total of 18 new acorane-type sesquiterpenes are obtained from the deep-sea-derived fungus P. bilaiae F-28. Although the spiro[4.5] decane core of analogs from the F-28 strain is similar to that reported in the literature (Zhang et al, 2020), the distinct stereogenic centers of the analogs from this fungus to those derived from plants or the Trichoderma genus suggest the synthases with distinct stereospecific selections, implying a group of new synthases in this fungus. Bilaiacorenols A and B are structurally featured by the unique tricyclic acorane-type sesquiterpenes in nature.…”

“…Hitherto, less than 30 acorane-based sesquiterpenes have been reported from plants and microorganisms. Acrorans in plants are characteristic of the volatile metabolites which play crucial roles as biocontrol and biostimulant agents and are also considered the chemotaxonomic markers of the plant (Zhang et al, 2020). Biogenetically, acrorans are synthesized from farnesyl diphosphate (FPP) as a common precursor by catalysis using sesquiterpene synthases, of which EfCAS in the plant catalyzes the cyclization of FFP to afford a spiro [4.5]decane core such as eupho-acorenols A and B (Zhu et al, 2021).…”