A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137

Zhang, Jingyu; Li, Bixiao; Qin, Yuyue; Karthik, Loganathan; Zhu, Guoliang; Hou, Chengjian; Jiang, Lan; Liu, Miaomiao; Ye, Xin; Liu, Mei; Hsiang, Tom; Dai, Huanqin; Zhang, Lixin; Liu, Xueting

doi:10.1007/s00253-019-10217-2

Cited by 24 publications

(9 citation statements)

References 55 publications

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“…Further, this secondary metabolite inhibited E. faecalis and B. thuringiensis at the MIC values of 8.0 and 2.0 µg/mL, respectively. A novel polyketide compound abyssomicin Y (Figure 6, Compound 13) was isolated from the marine-sediment-derived Verrucosispora strain MS100137, which exhibited potent antiviral activity against the influenza A virus at a concentration of 10 µM [133]. Certain marine bacteria have great potential for producing varied and remarkable characteristics, such as pigment production [134].…”

Section: Antimicrobial Potential Of Marine Sediment-derived Bacteriamentioning

confidence: 99%

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

et al. 2021

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The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996–2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora.

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Section: Antimicrobial Potential Of Marine Sediment-derived Bacteriamentioning

confidence: 99%

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

et al. 2021

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“…Berezin et al proved that the extracts of extremophilic actinomycetes strains K-192-2S, K-340-2S, and K-362-2N had significant antiviral activity through the inhibition of NA activity of all tested strains of influenza A virus, indicating that their commercial value may be higher than that of oseltamivir [114]. In recent years, metabolites of marine organisms have also attracted extensive attention owing to their greater diversity in structure and function compared to terrestrial organisms [115]. Actinomycetes are widely distributed in the ocean and can produce metabolites with diverse biological activities.…”

Section: Development and Role Of Microbial Metabolites In Influenza Vmentioning

confidence: 99%

“…Actinomycetes are widely distributed in the ocean and can produce metabolites with diverse biological activities. For example, the sea Verrucosispora is a rare actinomycetes that can secrete a variety of biologically active metabolites, such as Compounds 1-3, with a good inhibitory effect on H1N1 influenza virus [115]. In addition, Wang et al isolated a new sesterterpene called L435-3 from the phytopathogenic fungus Bipolaris oryzae and proved that L435-3 has strong antiviral activity against influenza, including against WSN and PR8 viruses [116,117].…”

Section: Development and Role Of Microbial Metabolites In Influenza Vmentioning

confidence: 99%

Development and Effects of Influenza Antiviral Drugs

et al. 2021

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Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development.

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“…Although markedly understudied, the Verrucosispora genus has attracted some attention due to the demonstratable bioactive potential of its secondary metabolites. Since the taxon was established in 1998, there have been discoveries of novel antibiotic (9), antitumor (10), anti-influenza A (11), and anti-HIV activities (12,13).…”

Section: Introductionmentioning

confidence: 99%

Phenogenomic characterization of a newly domesticated and novel species from the genus Verrucosispora

Kennedy

Atkinson

Tomlinson

et al. 2021

Preprint

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The concept of bacterial dark matter stems from our inability to culture most microbes and represents a fundamental hole in our knowledge of microbial diversity. Herein we present the domestication of such an organism: a previously uncultured, novel species from the rare-Actinomycetes genus Verrucosispora. Although initial recovery took >4 months, isolation of phenotypically distinct, domesticated generations occurred within weeks. Two isolates were subjected to phenogenomic analyses, revealing domestication correlated with enhanced growth rates in nutrient-rich media, but diminished capacity to metabolize diverse amino acids. This is seemingly mediated by genomic decay through the pseudogenization of amino acids metabolism genes. Conversely, later generational strains had enhanced spore germination rates, potentially through the reversion of a sporulation-associated kinase from pseudogene to true gene status. We observed that our most wild-type isolate had the greatest potential for antibacterial activity, which correlated with extensive mutational attrition of biosynthetic gene clusters in domesticated strains. Comparative analyses revealed wholesale genomic reordering in strains, with widespread SNP, indel and pseudogene mutations observed. We hypothesize that domestication of this previously unculturable organism resulted from the shedding of genomic flexibility required for life in a dynamic marine environment, parsing out genetic redundancy to allow for a newfound cultivable amenability.

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A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137

Cited by 24 publications

References 55 publications

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

Development and Effects of Influenza Antiviral Drugs

Phenogenomic characterization of a newly domesticated and novel species from the genus Verrucosispora

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