A new 68Ge/68Ga radioisotope generator system

Arino, Hirofumi; Skraba, Walter J.; Kramer, H.H.

doi:10.1016/0020-708x(78)90035-2

Cited by 26 publications

(6 citation statements)

References 5 publications

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“…Various generator systems have been studied. [56] Recently developed “ionic” 68 Ge/ 68 Ga generators provide Ga +3 for labeling of molecules. [78] Somatostatin peptide analogues like DOTATATE, DOTANOC, and DOTATOC have been labeled with 68 Ga for somatostatin receptor imaging.…”

Section: Introductionmentioning

confidence: 99%

Quality control of positron emission tomography radiopharmaceuticals: An institutional experience

et al. 2013

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Purpose of the Study:To study quality control parameters of routinely prepared positron emission tomography (PET) radiopharmaceuticals.Materials and Methods:Three PET radiopharmaceuticals fluorine-18 fluorodeoxyglucose (F-18 FDG), N-13 ammonia (N-13 NH3), and Ga-68 DOTATATE (n = 25 each), prepared by standardized protocols were used. The radionuclide purity, radiochemical purity, residual solvents, pH, endotoxins, and sterility of these radiopharmaceuticals were determined.Results:The physical half-life of radionuclide in radiopharmaceuticals, determined by both graphical and formula method, demonstrated purity of radionuclides used. pH of all PET radiopharmaceuticals used was in the range of 5-6.5. No microbial growth was observed in radiopharmaceutical preparations. The residual solvents, chemical impurity, and pyrogens were within the permissible limits.Conclusions:All three PET radiopharmaceuticals were safe for intravenous administration.

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Section: Introductionmentioning

confidence: 99%

Quality control of positron emission tomography radiopharmaceuticals: An institutional experience

et al. 2013

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“…appeared to be adequate, because they effectively adsorb the parent radionuclide 68 Ge IV . 1,25,26,33,39 Alternatively, organic resins have been developed which require more concentrated HCl soltuions for eluting the 68 Ga. 3,45 Figure 4 gives a schematic overview.…”

Section: +mentioning

confidence: 99%

68Ge/68Ga Generators and 68Ga Radiopharmaceutical Chemistry on Their Way into a New Century

Rösch¹

2013

Journal of Postgraduate Medicine, Education and Research

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68Ga faces a renaissance initiated by the development of new 68Ge/68Ga radionuclide generators, sophisticated 68Ga radiopharmaceuticals, preclinical research and state-of-the-art clincial diagnoses via positron emission tomography/computed tomography (PET/CT). A new type of 68Ge/68Ga generator became commercially available in the first years of the 21st century, with eluates based on hydrochloric acid. These generators provided ‘cationic’ 68Ga instead of ‘inert’ 68Gacomplexes, and opened new pathways of MeIII radiopharmaceutical chemistry. The last decade has seen a 68Ga rush. Increasing interest in generator-based 68Ga radiopharmaceuticals in diagnostic applications has been accompanied by its potential use in the context of diease treatment planning, made possible by the inherent option expressed by theranostics. However, widespread acceptance and clinical application requires optimization of 68Ge/68Ga generators both from chemical and regulatory perspectives. How to cite this article Rösch F. 68Ge/68Ga Generators and 68Ga Radiopharmaceutical Chemistry on Their Way into a New Century. J Postgrad Med Edu Res 2013;47(1):18-25.

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“…In the last 30 years the positron emission tomography (PET) has acquired relevance among the current conventional imaging methods such as X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) [ 3 ]. PET gives insights in the metabolism of living organisms and allows to detect diseases of neurological or oncological origin [ 4 – 5 ]. It is a nuclear medicine imaging technique that produces 3D images of functional processes in the body.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials

Saadat¹,

Renz²

2016

Beilstein J. Nanotechnol.

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SummaryCoated magnetite nanoparticles were linked to 68Ga complexes used in the positron emission tomography (PET) for a new technical approach to detect cancer tissue with radiopharmaceuticals. By substitution of the Ga isotope with an alpha emitter the same compound could be used for cancer treatment. Furthermore the nanoparticles were connected to pH-sensitive complexes, enabling a pH-controlled assembly/disassembly and therefore the spreading of the particles in the tissue. With this novel method of combining detection and treatment simultaneously, the amount of medical exposure could be minimized for the patient. The results demonstrate that magnetite nanoparticles can effectively be functionalized with PET isotopes and pH sensitive complexes in order to use them as a new type of radiopharmaceuticals.

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A new 68Ge/68Ga radioisotope generator system

Cited by 26 publications

References 5 publications

Quality control of positron emission tomography radiopharmaceuticals: An institutional experience

Quality control of positron emission tomography radiopharmaceuticals: An institutional experience

68Ge/68Ga Generators and 68Ga Radiopharmaceutical Chemistry on Their Way into a New Century

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials

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