Experimental and theoretical evidence supporting the L€ owdin model of DNA specificity is presented. Molecular genetic measurements by the transcriptase demonstrate that timedependent point lesions, G-C ! G 0 -C 0 and G-C ! *G-*C, are consequences of keto-amino ! enol-imine arrangement. Product enol-imine protons are shared between two sets of indistinguishable electron lone-pairs, and thus, participate in coupled quantum oscillation at frequencies of $10 13 s À1 . Transcriptase genetic specificity is determined by components contributing to the formation of complementary hydrogen bonds, which in these cases are variable because of coupled quantum oscillations. In an interval Dt \ 10 À13 s, genetic specificities are measured and executed before an entanglement is created between coherent protons and the transcriptase. The ensuing entanglement causes a decoherent transition from quantum to classical, yielding a statistical ensemble of decohered enol and imine isomers that participate in Topal-Fresco substitution replication. Coherent states within *A-*T sites are deleted. Using approximate quantum methods for times t \ $ 100 years, the probability, P(t), of keto-amino ! enol-imine arrangement is P q ðtÞ ¼ 1 =2ðc q = hÞ 2 t 2 where c q is the energy shift between states. This model illustrates biological consequences of coherent states populating inherited (CAG) n repeats in human genomes.