A neurosarcoidosis case with pituitary stalk involvement manifesting as hypogonadism and hyperprolactinemia

Hypothalamic-Pituitary Axis Dysfunction, Central Diabetes Insipidus, and Syndrome of Inappropriate Antidiuretic Hormone Secretion as the First Clinical Presentation of Neurosarcoidosis: Why Early Diagnosis and Treatment is Important?

“…Moreover, endocrine changes primarily occur in previously undiagnosed cases of neurosarcoidosis, further reinforcing the importance of considering this condition as a differential diagnosis when evaluating the underlying reason for HP dysfunction. Correct and prompt diagnosis and treatment should be ensured since early treatment may salvage pituitary function [7][8][9][10].…”

“…The significant limitation of this study is that it included only four patients. Published cases over the last several years show that the initial manifestations of sarcoidosis may be panhypopituitarism, hyperprolactinemia, hypogonadotropic hypogonadism, thyrotropin dysfunction and amenorrhoea, hypothermia, syndrome of inappropriate antidiuretic hormone secretion (SIADH), and central diabetes insipidus (DI) [9,10,[12][13][14][15][16]. The diagnosis of neurosarcoidosis was delayed in a substantial number of cases.…”