A Neuropsychiatric Presentation of Seronegative Autoimmune Encephalitis: A Case Report

Ismail, Muhammad; Moloney, Eimer; Costello, Daniel J.; Sweeney, Brian; Cassidy, Eugene

doi:10.14740/jmc2297w

Cited by 1 publication

(2 citation statements)

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“…With no positive outcome from other modalities of treatment, TPE was performed using albumin and saline as the replacement fluids (albumin 90%, normal saline 10%) [10]. This experience of sustained remission with clinical improvement in a patient of suspected autoimmune encephalitis following TPE procedures is in-line with a similar case report of adult sero-negative auto-immune encephalitis who responded to plasmapheresis and rituximab [7].…”

Section: Discussionmentioning

confidence: 81%

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Therapeutic Plasma Exchange in Treatment of Autoimmune Encephalitis: A Case Report

Pathak,

Dubey,

Singh

et al. 2023

AJPR

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The present study highlights the Therapeutic Plasma Exchange in treatment of Autoimmune Encephalitis. Due to the similarities in the clinical, imaging, and laboratory findings of many forms of autoimmune and infectious encephalitis, autoimmune encephalitis is frequently a difficult clinical diagnosis. Diagnosis of autoimmune encephalitis is based on the clinical course, serological evidence of autoimmunity, EEG changes, evidence of intrathecal inflammation in the cerebrospinal fluid and neuroimaging by MRI. In view of the suspected diagnosis of Autoimmune Encephalopathy with super refractory Status Epilepticus, Methylprednisolone was later added to the treatment. This case represents an interesting scenario of sero-negative encephalitis in which an early diagnosis could be made and treatment initiated in time.

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Section: Discussionmentioning

confidence: 81%

“…However, in 60% of cases of encephalitis, the cause remains unknown. Seronegative autoimmune encephalitis is a subgroup of encephalitis with suspected immunologic origin but with no identifiable pathogenic autoantibody [7].…”

Section: Discussionmentioning

confidence: 99%