A neurophysiological insight into the potential link between transcranial magnetic stimulation, thalamocortical dysrhythmia and neuropsychiatric disorders

Fuggetta, Giorgio; Noh, Nor Azila

doi:10.1016/j.expneurol.2012.10.010

Cited by 46 publications

(44 citation statements)

References 58 publications

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“…With the results of this study, we support the current opinion in functional neuroimaging literature that the application of a "resting-state" experimental design, which is not dependent on subject compliance or on task-specific factors, is suitable for studying both neuropsychiatric disorders (Greicius, 2008;Hinkley et al, 2011) and healthy subjects (Fuggetta and Noh, 2012). Our results also suggest that qEEG measures of spectral power (in …”

Section: Discussionsupporting

confidence: 86%

“…An electrophysiological conception considers the fundamental role of dysfunctional oscillations in patients (at rest or while performing a task) in the generation of cognitive deficits and symptomatology in a range of neurological and psychiatric disorders (Fuggetta and Noh, 2012;Llinas et al, 1999;Schulman et al, 2011;Uhlhaas and Singer, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative electroencephalography as a biomarker for proneness toward developing psychosis

Fuggetta

Bennett

Duke

et al. 2014

Schizophrenia Research

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The fully dimensional approach to the relationship between schizotypal personality traits and schizophrenia describes schizotypy as a continuum throughout the general population ranging from low schizotypy (LoS) and psychological health to high schizotypy (HiS) and psychosisproneness. However, no biological markers have yet been discovered that reliably quantify an individual's degree of schizotypy and/or psychosis. This study aimed to evaluate quantitative electroencephalographic (qEEG) measures of power spectra as potential biomarkers of the proneness towards the development of psychosis in schizotypal individuals. The resting-state oscillatory brain dynamics under eyes-closed condition from 16 LoS and 16 HiS individuals were analysed for qEEG measures of background rhythm frequency, relative power in δ, θ, low-α, high-α, low-β, high-β and low-γ frequency bands, and the high-temporal crosscorrelation of power spectra between low-and high-frequency bands observed by averaging signals from whole-head EEG electrodes. HiS individuals at rest locked the thalamocortical loop in the low-α band at a lower-frequency oscillation and displayed an abnormally high level of neural synchronisation. In addition, the high-α band was found to be positively correlated with both the high-β and low-γ bands unlike LoS individuals, indicating widespread thalamocortical resonance in HiS individuals. The increase of regional alpha oscillations in HiS individuals suggests abnormal high-level attention, whereas the pattern of correlation between frequency bands resembles the thalamocortical dysrhythma phenomenon which underlies the symptomatology of a variety of neuropsychiatric disorders including schizophrenia. These qEEG biomarkers may aid clinicians in identifying HiS individuals with a high-risk of developing psychosis.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Quantitative electroencephalography as a biomarker for proneness toward developing psychosis

Fuggetta

Bennett

Duke

et al. 2014

Schizophrenia Research

Self Cite

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“…Third, symptoms could be caused by abnormal connectivity within a brain network, and stimulation of any node of this network could alter such connectivity (35,42,126,(134)(135)(136)(137)(138)(139). Finally, symptoms could be caused by pathological oscillations occurring within a network, and stimulation of any node of the network could break this pathological rhythm (33,(140)(141)(142)(143)(144).…”

Section: Brain Diseases Treated With Both Invasive and Noninvasive Stmentioning

confidence: 99%

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Fox

Buckner

Liu

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

514

435

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Significance Brain stimulation is a powerful treatment for an increasing number of psychiatric and neurological diseases, but it is unclear why certain stimulation sites work or where in the brain is the best place to stimulate to treat a given patient or disease. We found that although different types of brain stimulation are applied in different locations, targets used to treat the same disease most often are nodes in the same brain network. These results suggest that brain networks might be used to understand why brain stimulation works and to improve therapy by identifying the best places to stimulate the brain.

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“…In additon, functional connectivity between the pgACC and the left amygdala was negatively associated with depression symptom reduction, suggesting that syncronization of this circuit may play a role in maintaining depression (Salvadore et al, 2010). We hypothesized that TMS temporarily interferes with the pathologic synchronization of anterior cingulate gyrus function and that this interference could make combined ketamine/TMS treatment a very useful therapy in the everyday toolbox at the clinic (Allen, Pasley, Duong, & Freeman, 2007;Briggs & Usrey, 2008;Esser, Hill, & Tononi, 2005;Fuggetta & Noh, 2013;Johnson, Hamidi, & Postle, 2010;Massimini, Ferrarelli, Sarasso, & Tononi, 2012;Sherman, 2007;Thut et al, 2011).…”

Section: Scientific Rationalementioning

confidence: 99%

Rapid Relief of Treatment Resistant Depression by Facilitated Ketamine Infusion: A Preliminary Report

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2014

Act Nerv Super

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By combining transcranial magnetic stimulation (TMS) with intravenous ketamine therapy, we sought to increase the therapeutic value of TMS and, at the same time, to improve the efficacy of intravenous ketamine therapy among depressed patients previously classified as non-responders. In this preliminary report, we provide evidence for a new and much more reliable method of treating patients with treatment resistant depression. Twenty-eight patients with various degrees of treatment unresponsive depression were treated with a combination of TMS and ketamine infusion. Of these patients, twenty received pretreatment for 3 days to 2 weeks involving intensive (thrice daily) rTMS treatment administered 6 or 7 days/week or priming TMS treatment immediately prior to the combination TMSketamine infusion combination therapy. Eight patients received neither pretreatment nor priming. All of the 28 patients who did fully participate in the first month of treatment experienced relief of psychiatric symptoms, and showed significant psychosocial recovery. In contrast to previous studies examining ketamine or rTMS individually, the positive outcomes presented here suggest a synergistic effect of the combination therapy of TMS and ketamine infusion.

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A neurophysiological insight into the potential link between transcranial magnetic stimulation, thalamocortical dysrhythmia and neuropsychiatric disorders

Cited by 46 publications

References 58 publications

Quantitative electroencephalography as a biomarker for proneness toward developing psychosis

Quantitative electroencephalography as a biomarker for proneness toward developing psychosis

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

Rapid Relief of Treatment Resistant Depression by Facilitated Ketamine Infusion: A Preliminary Report

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