A neuropharmacological study of Lisanul Asafir (seeds of Wrightia tinctoria, Br.) — a Unani herbal drug

Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

“…The higher dose of 200 and 300 mg/kg showed significant supramaximal electroshock seizure indicating anticonvulsant activity of test drug with LD 50 determined to 891.25 mg/kg in the mice. These results indicate that the drug has central depressant, muscular relaxant and anticonvulsant activity [128]. Murugnandan et al also studied anxiolytic and antidepressant effect of W. tinctoria leaves on brain monoamines and metabolites in rats [129].…”

“…Moreover, neuropharmacological potential of seeds of W. tinctoria has also been studied [128]. 50% alcoholic extract when studied for central action on mice, the drug diminished the alertness, grooming and spontaneous locomotory activity and pain response in gross behavioral studies.…”