A Neurofunctional Evaluation Strategy for Presurgical Selection of Temporal Lobe Epilepsy Patients

Chacón, Lilia María Morales; Catasús, Carlos Sánchez; Bender, J.; Bosch-Bayard, Jorge; García, María Eugenia; Maeso, Iván García; Pedré, Lourdes Lorigados; Díaz, Bárbara Estupiñán; Quincoses, Otto Trápaga; Martín, Margarita Báez; Coroneaux, Abel Sánchez; Madrigal, Digna Pérez; Guevara, Miriam; Bermúdez, Marilyn Zaldivar; Águila, Ángel

doi:10.37757/mr2009v11.n1.9

Cited by 7 publications

(1 citation statement)

References 39 publications

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“…One of the quantitative approaches used for many years has been the classical method based on regions of interest (ROI). Although this method is useful in several situations (e.g., see [5][6][7][8]), its main constrain is that the analysis is based on the average across all voxels in each ROI. The voxel-based approach overcomes this problem [9,10].…”

Section: Introductionmentioning

confidence: 99%

Brain connectivity by single-photon emission computed tomography and graph theory: a mini-review

Sanchez-Catasus,

Batista-García-Ramó,

Melie-Garcia

2023

Academia Medicine

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Current neuroimaging technologies play an important role in neurological disorders. Among these technologies, nuclear medicine neuroimaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) play a key role. The relevance of brain SPECT is that it has lower costs and greater availability compared to brain PET. Quantitative methods used in brain SPECT are generally univariate. The main limitation of these methods is that they do not allow investigating the relationship between brain regions (i.e. connectivity). One of the multivariate methods that has proven to be useful is graph theory. In this article, we review brain connectivity modeling based on this approach applied to brain SPECT. We also include some clinical studies to illustrate the potential of this method to detect subtle changes in brain connectivity. Recent advancements in new SPECT technology detectors could be the basis for the next level of use of this analysis methodology in the near future.

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Section: Introductionmentioning

confidence: 99%

Brain connectivity by single-photon emission computed tomography and graph theory: a mini-review

Sanchez-Catasus,

Batista-García-Ramó,

Melie-Garcia

2023

Academia Medicine

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Epilepsy surgery in low- and middle-income countries: A scoping review

Watila

Xiao

Keezer

et al. 2019

Epilepsy & Behavior

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Background: Epilepsy surgery is an important treatment option for people with drug resistant epilepsy. Although surgical procedures are under-utilized worldwide, it is far worse in Low-and Middle-Income Countries (LMIC) and it is less clear to what extent people with drug resistant epilepsy receive such treatment at all. Here we review the existing evidence for the availability and outcome of epilepsy surgery in LMIC, and discuss some challenges and priority. Methods: We used the six stage methodological framework developed by Arskey and O'Malley as a guide. We searched PubMed, Embase, Global Health Archives, Index Medicus for South East Asia Region (IMSEAR), Index Medicus for Eastern Mediterranean Region (IMEMR), Latin American & Caribbean Health Sciences Literature (LILACS), African Journal Online (AJOL), and African Index Medicus (AIM) to identify the relevant literature. Results: We retrieved 148 articles on epilepsy surgery from 31 countries representing 22% of the 143 LMIC. Epilepsy surgery appears established in some of these centers in Asia and Latin America, while some are in their embryonic stage reporting procedures in a small cohort performed mostly by motivated neurosurgeons. The commonest surgical procedure reported was temporal lobectomies. The post-operative seizure-free rates and quality of life are comparable to those in the high-income countries (HIC). Some models have shown that epilepsy surgery can be performed within a resourcelimited setting through collaboration with international partners and through the use of information and communication technology. The cost of surgery is a fraction of what is available in HIC. Conclusion: This review has demonstrated the availability of epilepsy surgery in few LMIC. The information available is inadequate to make any reasonable conclusion of its existence as routine practice. Collaborations with international partners can provide an opportunity to bring high-quality academic training and technological transfer directly to surgeons working in these regions and should be encouraged.

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Improving Electroencephalographic Source Localization of Epileptogenic Zones With Time-Frequency Analysis

Cuspineda-Bravo¹,

Martı́nez-Montes

Farach-Fumero³

et al. 2014

Clin EEG Neurosci

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The combination of recently developed methods for electroencephalographic (EEG) space-time-frequency analysis can provide noninvasive functional neuroimages necessary for obtaining an accurate localization of the epileptogenic zone. The aim of this study was to determine if time-frequency (TF) analysis, followed by EEG source localization, would improve the detection and identification of epileptogenic and related activity. Seventeen patients with refractory frontal lobe epilepsy (FLE) were studied using video EEG recording. TF analysis identified the first epileptogenic EEG changes. Using the Bayesian model averaging (BMA) approach, we compared brain electromagnetic tomographic (BET) images, constructed from the TF domain, with BET images constructed from the time domain only. We determined if the localization identified by BET images was concordant with the localization from medical history and video EEG recording. TF analysis provided a clear display of subtle EEG features, including EEG lateralization, and more concordant and delimited epileptogenic zones, compared with time-domain source analysis. In conclusion, EEG TF analysis improves source localization. After a thorough validation, this methodology could become a useful noninvasive tool for localizing the epileptogenic zone in clinical practice.

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A Neurofunctional Evaluation Strategy for Presurgical Selection of Temporal Lobe Epilepsy Patients

Cited by 7 publications

References 39 publications

Brain connectivity by single-photon emission computed tomography and graph theory: a mini-review

Brain connectivity by single-photon emission computed tomography and graph theory: a mini-review

Epilepsy surgery in low- and middle-income countries: A scoping review

Improving Electroencephalographic Source Localization of Epileptogenic Zones With Time-Frequency Analysis

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