A Neural Probe With Up to 966 Electrodes and Up to 384 Configurable Channels in 0.13 $\mu$m SOI CMOS

Abstract

Mora Lopez, C. et al. (2017) A neural probe with up to 966 electrodes and up to 384 configurable channels in 0.13 μm SOI CMOS. IEEE Transactions on Biomedical Circuits and Systems, 11(3), pp. 510-522. (doi:10.1109/TBCAS.2016.2646901) This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/139992/

Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites

“…In this application, the implanted probe shank needs to be sufficiently long to reach deep brain structures ( Figure 1 a), but it also needs to have a reduced cross section to minimize tissue damage. Active silicon neural probes that have been recently developed consist of a large number of tiny active electrodes that can locally amplify/buffer the neural signals [ 1 , 2 , 3 , 4 ]. However, with such limited space for each active electrode, the CMOS (complementary metal-oxide-semiconductor) pixel amplifiers (PA) underneath the electrodes are restricted to a bare minimum, while most of the signal processing is done in the ‘base’ (i.e., non-implantable part) of the probe.…”

Time multiplexed active neural probe with 678 parallel recording sites

“…Together, these blocks implement the noise reduction technique described in Section 2.2, with individual blocks further described in Section 4. The outputs of 20 channels are multiplexed and digitized with the help of a 10-bit successive approximation register (SAR) analog to digital converter (ADC) [4]. The number of multiplexed According to the simulation results, the power dissipation limits that would produce a 1 • C increase in the tissue temperature are 4.5 mW for the entire implanted shank and 45 mW for the base.…”

A Novel General Purpose Combined DFVF/VCII Based Biomedical Amplifier

“…Due to all the aforementioned aspects, electronic recording circuits and systems require a very low noise first interfacing stage that in most cases is formed by a high-impedance input voltage amplifier. Several architectures implementing such circuits have been proposed in the literature [27][28][29][30][31][32][33], but there is a continuous demand for novel and improved-performance topologies in order to achieve an ultra-large-scale integrated solution. In particular, in the biomedical acquisition system literature, different electronic interfaces have been proposed, in order to minimize the interference voltage contribution, usually by achieving a very high input impedance and high CMRR values.…”