A neural basis for tonic suppression of sodium appetite

Park, S.; Williams, Kevin W.; Liu, Chen; Sohn, Jong Woo

doi:10.1038/s41593-019-0573-2

Cited by 26 publications

(36 citation statements)

References 41 publications

(62 reference statements)

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“…The PBN consists of many cell types that mediate separable aspects of feeding and aversion ( 3 , 10 , 57 , 58 ). Of these cell types, neurons expressing CGRP located in the ventral/external lateral parabrachial (PBNel) thought to function as a general alarm system that sends aversive signals throughout the brain are of the most notable ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding

et al. 2021

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An animal’s evolutionary success depends on the ability to seek and consume foods while avoiding environmental threats. However, how evolutionarily conserved threat detection circuits modulate feeding is unknown. In mammals, feeding and threat assessment are strongly influenced by the parabrachial nucleus (PBN), a structure that responds to threats and inhibits feeding. Here, we report that the PBN receives dense inputs from two discrete neuronal populations in the bed nucleus of the stria terminalis (BNST), an extended amygdala structure that encodes affective information. Using a series of complementary approaches, we identify opposing BNST-PBN circuits that modulate neuropeptide-expressing PBN neurons to control feeding and affective states. These previously unrecognized neural circuits thus serve as potential nodes of neural circuitry critical for the integration of threat information with the intrinsic drive to feed.

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Section: Discussionmentioning

confidence: 99%

Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding

et al. 2021

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“…Many authors have contemplated the functional roles of projections from the PB to specific target regions. These include: regulating body temperature in the preoptic area and hypothalamus (Geerling et al, 2016; Nakamura & Morrison, 2008, 2010); influencing attention or arousal through the hypothalamus, thalamus, amygdala, basal forebrain, or cerebral cortex (Chou et al, 2002; Fuller, Sherman, Pedersen, Saper, & Lu, 2011; Kaur et al, 2013; Kaur et al, 2017; Qiu, Chen, Fuller, & Lu, 2016; Saper, 1982; Saper & Loewy, 1980); relaying danger signals to a variety of brain regions (Campos et al, 2018; Chiang et al, 2019; Palmiter, 2018; Saper, 2016); inhibiting food, salt, and water intake in the CeA or hypothalamus (Carter et al, 2013; Carter et al, 2015; Kim et al, 2020; Park et al, 2020; Ryan et al, 2017); and modulating autonomic function in the hindbrain, hypothalamus, CeA, or BST (Chamberlin & Saper, 1992, 1994; Davern, 2014; Saper & Loewy, 1980; Yokota, Kaur, VanderHorst, Saper, & Chamberlin, 2015). For the most part, we will reserve discussion of brain regions not innervated by FoxP2 or Pdyn neurons for future publications focusing on the PB subpopulations that do target those regions, but here we will highlight three functionally relevant observations derived from our new neuroanatomical data.…”

Section: Discussionmentioning

confidence: 99%

“…This groundwork of neuroanatomical knowledge helped identify a role for PB neurons in a wide variety of homeostatic functions. These include taste signaling (Norgren, 1976; Norgren & Leonard, 1971, 1973), hunger (Carter, Han, & Palmiter, 2015; Carter, Soden, Zweifel, & Palmiter, 2013; Garfield et al, 2015; Kim et al, 2020; Li et al, 2019; Wu, Clark, & Palmiter, 2012), thirst and sodium appetite (Geerling et al, 2011; Lee et al, 2019; Park, Williams, Liu, & Sohn, 2020; Ryan, Ross, Campos, Derkach, & Palmiter, 2017), thermoregulation (Geerling et al, 2016; Nakamura & Morrison, 2008, 2010; Yahiro, Kataoka, Nakamura, & Nakamura, 2017), nociception (Bester, Menendez, Besson, & Bernard, 1995; Chiang et al, 2019), breathing (Chamberlin & Saper, 1994; St John, Glasser, & King, 1972), hypercapnic arousal (Kaur et al, 2013; Kaur et al, 2017), cardiovascular control (Chamberlin & Saper, 1992; Miller et al, 2012), itch (Mu et al, 2017), and alarm (Campos, Bowen, Roman, & Palmiter, 2018; Palmiter, 2018; Saper, 2016).…”

Section: Introductionmentioning

confidence: 99%

Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice

Huang

Grady

Peltekian

et al. 2020

J of Comparative Neurology

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The parabrachial nucleus (PB) is a complex structure located at the junction of the midbrain and hindbrain. Its neurons have diverse genetic profiles and influence a variety of homeostatic functions. While its cytoarchitecture and overall efferent projections are known, we lack comprehensive information on the projection patterns of specific neuronal subtypes in the PB. In this study, we compared the projection patterns of glutamatergic neurons here with a subpopulation expressing the transcription factor Foxp2 and a further subpopulation expressing the neuropeptide Pdyn. To do this, we injected an AAV into the PB region to deliver a Cre-dependent anterograde tracer (synaptophysin-mCherry) in three different strains of Cre-driver mice. We then analyzed 147 neuroanatomical regions for labeled boutons in every brain (n = 11). Overall, glutamatergic neurons in the PB region project to a wide variety of sites in the cerebral cortex, basal forebrain, bed nucleus of the stria terminalis,

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“…The PBN consists of many cell-types that may mediate separable aspects of feeding and aversion (Campos et al, 2018; Fu et al, 2019; Park et al, 2020; Ryan et al, 2017). Of these cell-types, neurons expressing calcitonin gene-related peptide (CGRP) located in the vental/external lateral parabrachial (PBNel) thought to function as a general alarm system that sends aversive signals throughout the brain are of the most notable (Palmiter, 2018).…”

Section: Discussionmentioning

confidence: 99%

Extended amygdala-parabrachial circuits alter threat assessment to regulate feeding

Bhatti

Pedersen²,

Mulvey³

et al. 2020

Preprint

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29An animal's evolutionary success depends on the ability to seek and consume foods while 30 avoiding environmental threats. However, how evolutionarily conserved threat detection circuits 31 modulate feeding is unknown. In mammals, feeding and threat assessment are strongly 32 influenced by the parabrachial nucleus (PBN), a structure that responds to threats and inhibits 33 feeding. Here, we report that the PBN receives dense inputs from the bed nucleus of the stria 34 terminalis (BNST), an extended amygdala structure that encodes affective information. Using a 35 series of complementary approaches, we identify opposing BNST-PBN circuits that modulate a 36 genetically-defined population of PBN neurons to control feeding. This previously unrecognized 37 neural circuit integrates threat assessment with the intrinsic drive to eat. 38 39 Keywords: extended amygdala; bed nucleus of the stria terminalis; parabrachial nucleus; 40 feeding; threat assessment; anxiety; motivation 41 Main text: 42 43 Introduction 44All animals must successfully seek and consume food while avoiding environmental 45 threats to survive. The internal state of an animal directly impacts the expression of risky 46 behaviors, such as exploring a dangerous environment to obtain rewards and maintain 47 homeostasis. Animals must adaptively prioritize certain behaviors to appropriately respond to their 48 internal state (Alhadeff et al., 2018; Burnett et al., 2016). While many studies have explored the 49 interaction of metabolic need states with behavior, how mammals integrate affective-threat 50 assessment with internal need states remains largely unknown. 51Several recent reports have found that in mammals, food consumption and threat 52 assessment are heavily influenced by the parabrachial nucleus (PBN), a pontine structure that 53 integrates visceral and sensory information to encode metabolic needs (Campos et al., 2016(Campos et al., , 54 2018 Carter et al., 2013; Essner et al., 2017; Han et al., 2015; Mu et al., 2017; Roman et al., 55 2016; Ryan et al., 2017; Zséli et al., 2016). The amygdala and extended amygdala are 56 evolutionarily conserved brain regions that encode and integrate valence, stress, and threat to 57 alter behavioral states. Anatomical data suggest that the PBN receives input from several regions 58 that may encode affective information, including the bed nucleus of the stria terminalis (BNST), a 59 structure in the extended amygdala (Douglass et al., 2017; Kim et al., 2013; Mazzone et al., 2018; 60 Zséli et al., 2016). However, the neural circuit mechanisms that underlie the integration of an 61 animal's own motivation to eat with internal affective states regarding environmental threats are 62 still unknown. Here, we identified two previously unknown afferents from distinct populations 63 within the BNST to the PBN that underlie the complex integration of threat-assessment and 64 feeding signals to modulate PBN activity and ultimately regulate state-dependent feeding. 65 66 67 Results 68 Anatomical and Molecular...

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A neural basis for tonic suppression of sodium appetite

Cited by 26 publications

References 41 publications

Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding

Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding

Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice

Extended amygdala-parabrachial circuits alter threat assessment to regulate feeding

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