A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes
Giusy del Giudice,
Angela Serra,
Alisa Pavel
et al.
Abstract:Hazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity. However, systems toxicology emphasises how system properties significantly contribute to the observed response. Hence, systems theory states that interactions store more information than individual elements, leading to the adoption of network based models to represent complex syst… Show more
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