A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio‐Cerebral Vascular Diseases

Abstract

Objective. This study is aimed to analyze the active ingredients, drug targets, and related pathways in the combination of Salvia miltiorrhiza (SM) and Radix puerariae (RP) in the treatment of cardio-cerebral vascular diseases (CCVDs). Method. The ingredients and targets of SM and RP were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the disease targets were obtained from Therapeutic Target Database (TTD), National Center for Biotechnology Information (NCBI), and Online Mendelian Inheritance in Man (OMIM) Database. The synergistic mechanisms of the SM and RP were evaluated by gene ontology (GO) enrichment analyses and Kyoto encyclopedia of genes and genomes (KEGG) path enrichment analyses. Result. A total of 61 active ingredients and 58 common targets were identified in this study. KEGG pathway enrichment analysis results showed that SM- and RP-regulated pathways were mainly inflammatory processes, immunosuppression, and cardiovascular systems. The component-target-pathway network indicated that SM and RP exert a synergistic mechanism for CCVDs through PTGS2 target in PI3k-Akt, TNF, and Jak-STAT signaling pathways. Conclusion. In summary, this study clarified the synergistic mechanisms of SM and RP, which can provide a better understanding of effect in the treatment of CCVDs.

[Retracted] Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae Ameliorates Hypertensive Renal Damage

“…Simultaneously, treatment with RA may improve TGF-β1-induced renal fibrosis [15]. Studies reveal that RS can improve vascular function and structure and significantly improve the occurrence of hypertension [16], and RS and its extracts have been known to have an antioxidant BioMed Research International property and neuroprotective effects [17]. The combination of RA and RS exerts synergistic effect on HRD.…”

Protective Effect of Bojungikki‐Tang against Radiation‐Induced Intestinal Injury in Mice: Experimental Verification and Compound‐Target Prediction

“…The compound-protein and PPI networks were visualized, and the topological parameters of the signaling pathway-protein network were analyzed using Cytoscape 3.7.2 ( https://cytoscape.org ) [ 29 , 30 ]. After network analysis, functional annotation of genes was performed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID; https://david.ncifcrf.gov/ , version 6.8) system and the Kyoto Encyclopedia of Genes and Genomes (KEGG; https://www.genome.jp/kegg/ , Release 96.0, October 1, 2020) database.…”

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

“…Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is one of the typical blood-activating and stasis-resolving medicines, and it offers therapeutic promise for cerebrovascular diseases ( Ma Y. et al, 2020 ). Salvianolic acids and tanshinones are the main compounds in Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma].…”

“…Extraction components of single CHM (Table 1), CHM formulas (Table 2), and CHM preparations (Table 3) all show some benefit in removing blood stasis, which drives further studies for ischemic diseases more widely. Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is one of the typical blood-activating and stasisresolving medicines, and it offers therapeutic promise for cerebrovascular diseases (Ma Y. et al, 2020). Salvianolic acids and tanshinones are the main compounds in Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma].…”