A network pharmacology study with molecular docking to investigate the possibility of licorice against posttraumatic stress disorder

Qiu, Zhi-Kun; Liu, Zhiting; Pang, Jiali; Wu, Han-Biao; Liu, Xu; Yang, Zhifu; Xiong, Li; Chen, Jisheng

doi:10.1007/s11011-021-00816-2

Cited by 15 publications

(15 citation statements)

References 75 publications

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“…Generally, after 1 year of treatment, the child's sexual development symptoms will gradually disappear, and the height will gradually return to normal growth rate. Tamiflu is a long-acting Lin GnRHa drug, which in large doses can cause long-term competitive inhibition of pituitary GnRH receptor function, leads to the secretion of pituitary cells reduced susceptibility to long-term GnRH, which downregulates the secretion of gonadotropin and sex hormones, finally having an effect of inhibiting the gonads (27). Dafilin is a GnRHa, which can effectively inhibit the development of secondary sexual characteristics and the increase of bone age, and improve adult height.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the efficacy of Dabuyin pill combined with gonadotropin-releasing hormone analogue in the treatment of central precocious puberty girls based on network pharmacology

Chen¹,

Zheng²,

Fei³

et al. 2023

Transl Pediatr

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Background: Traditional Chinese medicine (TCM) believes that central precocious puberty (CPP) is affected by the imbalance of kidney Yin and Yang. Dabuyin pill is a recipe for nourishing Yin and lowering fire. The network pharmacology method was used to analyze the active components, action targets, and molecular pathways of Dabuyin pill in the treatment of CPP. Methods: The main chemical components of Dabuyin pill were obtained from the Integrative database of Traditional Chinese Medicine enhanced by Symptom Mapping (SymMap) database and Traditional Chinese Medicine Systems Pharmacology (TCMSP), and compound targets were retrieved from SymMap and the Encyclopedia of Traditional Chinese Medicine (ETCM). Disease targets were retrieved from the DisGeNET and Gene Expression Omnibus (GEO) databases, and the intersection of compound targets and disease targets was performed to obtain the prediction targets of Dabuyin pill acting on CPP. The key targets enriched by Database for Annotation, Visualization, and Integrated Discovery (DAVID) were then used for Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.Results: GO analysis showed that the biological functions of Dabuyin pill in the treatment of key targets of CPP mainly involved apoptosis, nitric oxide synthesis, estradiol response, angiogenesis, inflammation, and so on. KEGG pathway analysis was mainly enriched in the tumor necrosis factor (TNF) signaling pathway, phosphatidylinositol-3 kinase/protein kinase B (PI3K/Akt) signaling pathway, hypoxia-inducible factor-1 (HIF-1) signaling pathway, and apoptosis. Among them, the regulation effect of Dabuyin pill prescription on apoptosis may both act on TP53 and different signaling pathways of apoptosis, thus playing a synergistic role.Conclusions: Dabuyin pill combined with GnRHa for the prevention and treatment of CPP in girls can effectively intervene CPP, and the effect of Dabuyin pill on sex hormones is one of its protective mechanisms against CPP.

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Section: Discussionmentioning

confidence: 99%

Analysis of the efficacy of Dabuyin pill combined with gonadotropin-releasing hormone analogue in the treatment of central precocious puberty girls based on network pharmacology

Chen¹,

Zheng²,

Fei³

et al. 2023

Transl Pediatr

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“…Li et al explored the active component and mechanism of the anti-gastric-cancer effect of Herba Sarcandrae [ 40 ]. Qiu et al verified molecular evidence of the beneficial effects of licorice for the treatment of post-traumatic stress disorder using network pharmacology [ 41 ]. In addition, Ju et al determined an underlying mechanism of osthole in the treatment of gastric cancer and screened out target genes for osthole against gastric cancer using network pharmacology [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Potential mechanisms of osthole against bladder cancer cells based on network pharmacology, molecular docking, and experimental validation

Jiang

Zhang

Wang

et al. 2023

BMC Complement Med Ther

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Background Osthole was traditionally used in treatment for various diseases. However, few studies had demonstrated that osthole could suppress bladder cancer cells and its mechanism was unclear. Therefore, we performed a research to explore the potential mechanism for osthole against bladder cancer. Methods Internet web servers SwissTargetPrediction, PharmMapper, SuperPRED, and TargetNet were used to predict the Osthole targets. GeneCards and the OMIM database were used to indicate bladder cancer targets. The intersection of two target gene fragments was used to obtain the key target genes. Protein–protein interaction (PPI) analysis was performed using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Furthermore, we used gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to explore the molecular function of target genes. AutoDock software was then used to perform molecular docking of target genes,osthole and co-crystal ligand. Finally, an in vitro experiment was conducted to validate bladder cancer inhibition by osthole. Results Our analysis identified 369 intersection genes for osthole, the top ten target genes included MAPK1, AKT1, SRC, HRAS, HASP90AA1, PIK3R1, PTPN11, MAPK14, CREBBP, and RXRA. The GO and KEGG pathway enrichment results revealed that the PI3K-AKT pathway was closely correlated with osthole against bladder cancer. The osthole had cytotoxic effect on bladder cancer cells according to the cytotoxic assay. Additionally, osthole blocked the bladder cancer epithelial-mesenchymal transition and promoted bladder cancer cell apoptosis by inhibiting the PI3K-AKT and Janus kinase/signal transducer and activator of transcription (JAK/STAT3) pathways. Conclusions We found that osthole had cytotoxic effect on bladder cancer cells and inhibited invasion, migration, and epithelial-mesenchymal transition by inhibiting PI3K-AKT and JAK/STAT3 pathways in in vitro experiment. Above all, osthole might have potential significance in treatment of bladder cancer. Subjects Bioinformatics, Computational Biology, Molecular Biology.

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“… 38 Glycyrrhizin and other bioactive compounds in the root and stem of Licorice have been proven neuroprotective, antidepressant, and effective for PTSD remission. 35 The bioactive alkaloid―piperine, contained in Piper nigrum L, has shown antidepressive, antidiarrheal, analgesic, and immunomodulatory pharmacotherapeutic effects. 36 The phytochemicals in Zingiber officinal —6-shogaol and 6-gingerol, have induced antiviral, anti-inflammatory, immunomodulatory, neuroprotective, antiarthritic, antiasthmatic, and appetizing effects.…”

Section: Discussionmentioning

confidence: 99%

“… 29 , 30 Ashwagandha ( Withania sominfera ), Guduchi ( Tinospora cordifolia ), Tulsi ( Ocimum tenuiflorum ), seabuckthorn ( Hippophaes rhamnoides ), raisins ( Vitis vinifera ), Mulethi ( Licorice ), black pepper ( Piper nigrum L ), and ginger ( Zingiber officinal ) are the prominent medicinal plants containing vital phytochemicals with antimicrobial, antiviral, disinfectant, anti-inflammatory, neuroprotective, antidepressive, anxiolytic, atherosclerotic, hepatoprotective, antioxidant, immunomodulatory, analgesic, regenerative, appetizing, rejuvenating, and pharmacotherapeutic effects on COVID-19 infections and its neuropsychiatric comorbidities. 16 , 31 – 39 Reducing SARS-Cov-2 infection, inflammation, cytokine storm, degeneration, and distress using these Ayurvedic formulations might mitigate COVID-19-induced neuropsychiatric comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Online Yoga and Ayurveda Intervention as Tertiary Prevention of Psychological Comorbidities in COVID-19 Survivors: A Randomized Controlled Trial

Bhandari

2022

Annals of Neurosciences

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Background and Purpose About 56% of symptomatic COVID-19 survivors have been found with neuropsychological comorbidities, such as depression, anxiety, posttraumatic stress disorders (PTSD), and impaired quality of life (QoL). Alongside, antimicrobial, anti-inflammatory, neuroprotective, regenerative, immunomodulatory, cardio-pulmonary health promotive, and psychological benefits of yogic and Ayurvedic intervention are well documented. Therefore, this study aimed to assess the effect of online Yoga (OYI) and Yoga cum Ayurveda intervention (OYAI) on COVID-19-induced depression, anxiety, PTSD, and poor QoL. Method Seventy-two participants (males/females: 33/26) with at least a 3-month back history of symptomatic COVID-19 infection and age (mean ± SD: 32.33 ± 9.9 and 33.04 ± 12.9 for males and females, respectively) were recruited from Patanjali Ayurveda Hospital, Haridwar, India, and All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, before random allocation into an equal-sized control group (CG), Yoga group (YG) and Yoga cum concoction (YCG) group. Split-plot analysis of variance and Kruskal–Wallis tests with Bonferroni adjusted post hoc comparisons were computed for normal and nonnormal data using IBM SPSS (25th Version, SPSS South Asia Private Limited, Bangalore, India). Results Both the treatments—the 30-day OYI and OYAI, significantly improved depression ( P < .002, ES: -0.99 and P < .001, ES: -2.11), anxiety ( P < .001, ES: -1.32 and -1.89), PTSD ( P < .001, ES: -1.8 and -1.83) and QoL related constructs ( P < .001, ES: 0.63 and 0.76; 0.71 and 0.93 for each OYI and OYAI versus general health and physical health; P < .001, ES: 0.65 for OYAI versus psychological health; and P < .003, ES: 0.54 for OYI versus environment) of the participants compared to the controls. Conclusion OYAI may better ameliorate COVID-19-induced psychological comorbidities than OYI with no adverse effects.

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A network pharmacology study with molecular docking to investigate the possibility of licorice against posttraumatic stress disorder

Cited by 15 publications

References 75 publications

Analysis of the efficacy of Dabuyin pill combined with gonadotropin-releasing hormone analogue in the treatment of central precocious puberty girls based on network pharmacology

Analysis of the efficacy of Dabuyin pill combined with gonadotropin-releasing hormone analogue in the treatment of central precocious puberty girls based on network pharmacology

Potential mechanisms of osthole against bladder cancer cells based on network pharmacology, molecular docking, and experimental validation

Online Yoga and Ayurveda Intervention as Tertiary Prevention of Psychological Comorbidities in COVID-19 Survivors: A Randomized Controlled Trial

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