A Network of Krüppel-like Factors (Klfs)

Eaton, Sally A.; Funnell, Alister P. W.; Sue, Nancy; Nicholas, Hannah R.; Pearson, Richard; Crossley, Merlin

doi:10.1074/jbc.m804831200

Cited by 99 publications

(52 citation statements)

References 51 publications

(32 reference statements)

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“…In particular, we observed a marked increase specifically of histone 3 lysine 4 tri-methylation (H3K4me3) in Klf3 −/− cells at the ORR1A0 promoter (approximately 12-fold). We found that this mark was also increased at the promoters of previously validated KLF3 target genes such as Klf8 [50] and Fam132a / adipolin [49,54] (Figure 2E). H3K4me3 is a mark typically found at actively transcribed promoters [55].…”

Section: Resultsmentioning

confidence: 65%

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

et al. 2014

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BackgroundRetroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized.ResultsHere we show that the zinc finger protein Krüppel-like Factor 3 (KLF3) specifically silences transcription from the ORR1A0 long terminal repeat in murine fetal and adult erythroid cells. In the absence of KLF3, we detect widespread transcription from ORR1A0 elements driven by the master erythroid regulator KLF1. In several instances these aberrant transcripts are spliced to downstream genic exons. One such chimeric transcript produces a novel, dominant negative isoform of PU.1 that can induce erythroid differentiation.ConclusionsWe propose that KLF3 ensures the integrity of the murine erythroid transcriptome through the selective repression of a particular retroelement and is likely one of multiple sequence-specific factors that cooperate to achieve global silencing.

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Section: Resultsmentioning

confidence: 65%

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

et al. 2014

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“…KLF2, for example, positively regulates KLF1 in primitive erythroid cells (12). KLF8 is up-regulated by KLF1 and down-regulated by KLF3 (45). KLF1 also can activate KLF3 by directly binding to its promoter (46).…”

Section: Discussionmentioning

confidence: 99%

Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding

Alhashem

Vinjamur

Basu

et al. 2011

Journal of Biological Chemistry

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“…The Fog2-Gatamut sequence was synthesized by Epoch Biolabs (Sugar Land, TX) and inserted into the pMXspuro vector. The cDNA for full-length murine Ctbp2 (26) was inserted into the retroviral pMSCVpuro vector (27).…”

Section: Methodsmentioning

confidence: 99%

GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control Adipogenesis

Jack

Crossley

2010

Journal of Biological Chemistry

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A Network of Krüppel-like Factors (Klfs)

Cited by 99 publications

References 51 publications

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor

Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding

GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control Adipogenesis

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