A nested case-control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency

Abraham, Anuja; Mathews, Jiji Elizabeth; Sebastian, Ajit; Chacko, Kuruvilla P.; Sam, Dibu

doi:10.1111/ajo.12057

Cited by 6 publications

(4 citation statements)

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“…In relation to folate, some studies suggest a negative association between high maternal folate status and risk of low birth weight or small-for-gestational-age babies (van Uitert and SteegersTheunissen 2013). Meanwhile,vitamin B 12 deficiency has been associated with reduced birth weight (Wadhwani et al 2013), but no association with small-for-gestational-age babies has been found (Abraham et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

et al. 2014

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In this study, we evaluated the effects of dietary intake of vitamin B 12 and folate during pregnancy and their interactions with maternal polymorphism of MTHFR (677C[T; 1298A[C) on intrauterine development. Anthropometric parameters were obtained from 231 newborns that belong to a prospective birth cohort in Morelos, Mexico. Maternal dietary intake of vitamin B 12 and folate was assessed using a semi-quantitative questionnaire administered during the first and third trimesters of the pregnancy. Maternal MTHFR 677C[T and 1298 A[C genotypes were determined by PCR-RFLP. The associations between deficient dietary intake of vitamin B 12 (\2.0 lg/d) and folate (\400 lg/d) in the first and third trimesters and maternal polymorphisms of MTHFR on anthropometric parameters at birth were estimated using a multivariate linear regression model. During pregnancy, the deficient dietary intake was roughly 60 % for folate and 19 % for vitamin B 12 . Allelic frequencies of 677T and 1298C were 59 and 10 %, respectively. After adjusting for confounders, deficiency in maternal dietary intake of vitamin B 12 (\2.0 lg/d) was associated with a significant reduction in length (b * -2.4; 95 % CI -4.3; -0.6) and length-for-age at birth (b * -1.2; 95 % CI -2.3; -0.1) among infants whose mothers were carriers of the 677TT genotype (p for interaction = 0.02). In contrast, no association was observed between deficiency in maternal dietary intake of folate (\400 lg/d) and any anthropometric parameter of newborns. These results suggest that supplementation with vitamin B 12 during pregnancy could have a favorable impact on intrauterine fetal development mainly in populations that are genetically susceptible.

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Section: Introductionmentioning

confidence: 99%

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

et al. 2014

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“…Although the relationship between vitamin B 12 levels and birth weight is controversial, present study revealed significant association of first and second trimesters vitamin B 12 deficiency with LBW. Vitamin B 12 deficiency has been associated with LBW and intrauterine growth restriction (Rogne et al, ; Youssry, Radwan, Gebreel, & Patel, ; Ahmed, Akhter, Sharmin, Ara, & Hoque, ); however, a few studies did not find any association (Oztürk, Keskin, Tas, Akgün, & Avflar, ; Abraham, Mathews, Sebastian, Chacko, & Sam, . There is a need to improve the vitamin B 12 status among pregnant women as impaired status of maternal vitamin B 12 throughout pregnancy is a predictor for a high‐risk vitamin B 12 deficiency in infants (Finkelstein et al, ).…”

Section: Discussionmentioning

confidence: 99%

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

Mishra

Tomar

Puri

et al. 2020

American J Hum Biol

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Objective: To evaluate the effect of folate and vitamin B 12 levels on pregnancy progression and outcomes. Methods: The present study is a prospective follow up study of 100 pregnant women. Biochemical investigations (plasma homocysteine, folate, and vitamin B 12 levels) were performed on all pregnant women in first, second, and third trimesters. Nonparametric tests were used to compare the differences in median levels and odds ratio analysis for the assessment of the risk between the selected biomarkers and adverse pregnancy progression and outcomes. Results: The pregnant women at their first antenatal care visit were found to be predominantly folate replete (97%) and vitamin B 12 deficient (60%). Hyperhomocysteinemia in first and second trimesters was found to pose more than 3-fold increased risk for adverse pregnancy outcomes (P = .006 and .0002, respectively). Low birth weight (LBW) was found to be the most common adverse pregnancy outcome (52%), and was significantly associated with vitamin B 12 deficiency in the first and second trimesters (82%, P < .0001; 71.4%, P = .04, respectively). Conclusion: The vitamin B 12 deficiency is more common among Indian pregnant women as compared to folate deficiency. Hyperhomocysteinemia is an independent risk factor for pregnancy complications. Vitamin B 12 deficiency in first and second trimesters is associated with LBW babies.

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“…Levels of S-adenosylmethionine are also concomitantly reduced, decreasing the level of DNA methylation and are thereby thought to epigenetically reduce fetal growth [ 36 , 37 ]. Study results been conflicting regarding the association of vitamin B12 and birthweight with some reporting a positive association [ 38 – 41 ] and others observing no such association [ 42 – 46 ]. A recent study which did not observe an association between birth weight or length and maternal vitamin B12 levels found that when the ratio of maternal plasma folate to vitamin B12 was examined there was an inverse association with neonatal weight, length, head circumference and chest circumference but no association was observed with neonatal triceps or subscapular skinfold thickness [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

The association between maternal dietary micronutrient intake and neonatal anthropometry – secondary analysis from the ROLO study

Horan

McGowan

Gibney

et al. 2015

Nutr J

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BackgroundMicronutrients are necessary for fetal growth. However increasingly pregnant women are nutritionally replete and little is known about the effect of maternal micronutrient intakes on fetal adiposity in mothers with increased BMI. The aim of this study was to examine the association of maternal dietary micronutrient intake with neonatal size and adiposity in a cohort at risk of macrosomia.MethodsThis was a cohort analysis of 554 infants from the ROLO study. Three day food diaries from each trimester were collected. Neonatal weight, length, circumferences and skinfold thicknesses were measured at birth. Multiple linear regression was used to identify associations between micronutrient intakes and neonatal anthropometry.ResultsBirthweight was negatively associated with maternal trimester 3 vitamin D intake and positively associated with trimester 3 vitamin B12 intake R2adj 19.8 % (F = 13.19, p <0.001). Birth length was positively associated with trimester 3 magnesium intake R2adj 12.9 % (F = 8.06, p <0.001). In terms of neonatal central adiposity; abdominal circumference was positively associated with maternal trimester 3 retinol intake and negatively associated with trimester 3 vitamin E and selenium intake R2adj 11.9 % (F = 2.93, p = 0.002), waist:length ratio was negatively associated with trimester 3 magnesium intake R2adj 20.1 % (F = 3.92, p <0.001) and subscapular:triceps skinfold ratio was negatively associated with trimester 1 selenium intake R2adj7.2 % (F = 2.00, p = 0.047).ConclusionsMaternal micronutrient intake was associated with neonatal anthropometry even in women not at risk of malnutrition. Further research is necessary to determine optimal micronutrient intake in overweight and obese pregnant women.Trial registrationCurrent Controlled Trials ISRCTN54392969.Electronic supplementary materialThe online version of this article (doi:10.1186/s12937-015-0095-z) contains supplementary material, which is available to authorized users.

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A nested case-control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency

Abstract: No association between maternal vitamin B12 levels and fetal growth restriction was found in this study. Low birth weight babies were more common in women of low socioeconomic status.

Cited by 6 publications

References 13 publications

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

The association between maternal dietary micronutrient intake and neonatal anthropometry – secondary analysis from the ROLO study

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A nested case-control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency

Abstract: No association between maternal vitamin B12 levels and fetal growth restriction was found in this study. Low birth weight babies were more common in women of low socioeconomic status.

Cited by 6 publications

References 13 publications

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Trends of folate, vitamin B12, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes

The association between maternal dietary micronutrient intake and neonatal anthropometry – secondary analysis from the ROLO study

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Trends of folate, vitamin B₁₂, and homocysteine levels in different trimesters of pregnancy and pregnancy outcomes