A Neonatal Specialist With Recurrent Methicillin-Resistant Staphylococcus aureus (MRSA) Carriage Implicated in the Transmission of MRSA to Newborns

Méan, Marie; Mallaret, Marie-Reine; Andrini, P; Recule, C.; Debillon, Thierry; Pavèse, Patricia; Croizé, J.

doi:10.1086/513616

Cited by 18 publications

(10 citation statements)

References 18 publications

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“…2 It is well known that HCWs who are nasal carriers play an important role as sources of S. aureus transmission, and neonatal outbreaks due to HCWs colonizing strains have been previously reported. 8,27,33,42 In the present study, most HCWs were colonized with MSSA clonal types that were endemic in the unit and, therefore, may be acting as reservoirs of potential pathogenic MSSA strains inside the NICU. CA-MRSA outbreaks have been also described in NICUs due to vertical transmission from colonized parents.…”

Section: Discussionmentioning

confidence: 64%

Staphylococcus aureusReservoirs and Transmission Routes in a Portuguese Neonatal Intensive Care Unit: A 30-Month Surveillance Study

Conceição

Aires-de-Sousa²,

Miragaia³

et al. 2012

Microbial Drug Resistance

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Although Staphylococcus aureus is a major cause of outbreaks in neonatal intensive care units (NICUs), there are no studies on the epidemiology of S. aureus isolates responsible for infection in Portuguese NICUs. Between July 2005 and December 2007, a total of 54 methicillin susceptible S. aureus (MSSA) isolates were recovered from 16 infected infants, parents, health care workers (HCWs), and the environment in a level III NICU. Isolates were characterized by pulsed-field gel electrophoresis (PFGE), spa typing, and multilocus sequence typing. Virulence determinants were detected by multiplex polymerase chain reaction. Three major MSSA clones were endemic in the NICU, representing 70% (n = 38) of the isolates: PFGE type A-ST5 (n = 17); type B-ST30 (n = 12); and type C-ST1 (n = 9). Leukotoxins and hemolysins were present in all isolates, although none of them carried PVL. HCWs, plastic folders protecting clinical files, and mothers' nipples were identified as potential reservoirs and/or vehicles of dissemination of S. aureus. Consequently, additional infection control measures were implemented in this NICU.

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Section: Discussionmentioning

confidence: 64%

Staphylococcus aureusReservoirs and Transmission Routes in a Portuguese Neonatal Intensive Care Unit: A 30-Month Surveillance Study

Conceição

Aires-de-Sousa²,

Miragaia³

et al. 2012

Microbial Drug Resistance

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“…Since 2000, there has been an increasing number of reported outbreaks and cases caused by CA-MRSA strains. Several neonatal MRSA outbreaks have been linked to CA-MRSA strains (377,435,629), including USA300 (590,591,664,777,803) and USA400 (93) strains, and have been associated with visiting fathers (15), maternal mastitis (750, 807), expressed breast milk (313), peripartum maternal MRSA infection (255), and health care workers colonized or infected with MRSA, implying a community source (65,214,598,803).…”

Section: Neonatal Mrsa Infections and Maternal Colonization And Infecmentioning

confidence: 99%

Community-Associated Methicillin-ResistantStaphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

2010

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SUMMARY Staphylococcus aureus is an important cause of skin and soft-tissue infections (SSTIs), endovascular infections, pneumonia, septic arthritis, endocarditis, osteomyelitis, foreign-body infections, and sepsis. Methicillin-resistant S. aureus (MRSA) isolates were once confined largely to hospitals, other health care environments, and patients frequenting these facilities. Since the mid-1990s, however, there has been an explosion in the number of MRSA infections reported in populations lacking risk factors for exposure to the health care system. This increase in the incidence of MRSA infection has been associated with the recognition of new MRSA clones known as community-associated MRSA (CA-MRSA). CA-MRSA strains differ from the older, health care-associated MRSA strains; they infect a different group of patients, they cause different clinical syndromes, they differ in antimicrobial susceptibility patterns, they spread rapidly among healthy people in the community, and they frequently cause infections in health care environments as well. This review details what is known about the epidemiology of CA-MRSA strains and the clinical spectrum of infectious syndromes associated with them that ranges from a commensal state to severe, overwhelming infection. It also addresses the therapy of these infections and strategies for their prevention.

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“…The prevalence of more resistant and difficult-to-treat organisms such as MRSA [6,44], glycopeptide-resistant enterococci (GRE), Candida spp. and multidrugresistant Gram-negative organisms [4] is rising.…”

Section: Profile Of Infectionsmentioning

confidence: 99%

Recent trends and prevention of infection in the neonatal intensive care unit

Curtis

Shetty

2008

Current Opinion in Infectious Diseases

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A Neonatal Specialist With Recurrent Methicillin-Resistant Staphylococcus aureus (MRSA) Carriage Implicated in the Transmission of MRSA to Newborns

Cited by 18 publications

References 18 publications

Staphylococcus aureusReservoirs and Transmission Routes in a Portuguese Neonatal Intensive Care Unit: A 30-Month Surveillance Study

Staphylococcus aureusReservoirs and Transmission Routes in a Portuguese Neonatal Intensive Care Unit: A 30-Month Surveillance Study

Community-Associated Methicillin-ResistantStaphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

Recent trends and prevention of infection in the neonatal intensive care unit

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