“…In this model, wtf4 533 exploits protein aggregation control pathways to induce selective cell death. The Wtf4 poison forms 534 distributed toxic aggregates and the Wtf4 antidote co-assembles with the Wtf4 poison and neutralizes 535 of any other meiotic driver described to date(Grognet et al, 2014;Didion et al, 2015; Long et 537 al., 2008; Dawe et al, 2018;Rhoades et al, 2019; Dalstra et al, 2005; Hammond et al, 2012; 538Vogan et al, 2019, Chen et al, 2008Akera et al, 2017;Bauer et al, 2012; Pieper et al, 2018; 539Herrmann et al, 1999;Shen et al,2017; Yu, et al, 2018;Bauer et al, 2007; Wu et al, 1988; 540Xie, et al, 2019;Kruger et al, 2019;Lin et al, 2018), but there are very few mechanistically541 characterized gamete-killing drive systems (reviewed in Bravo Núñez et al, 2018). 542 543 Continued investigation into how fission yeast and budding yeast species handle Wtf4 544 aggregates may elucidate important biological features of the two yeasts as well as a more 545 detailed Wtf4 mechanism.…”