A nematicidal metabolite fromVerticillium chlamydosporium

Khambay, B. P. S.; Bourne, Jo M; Cameron, Stuart; Kerry, B. R.; Zaki, M. J.

doi:10.1002/1526-4998(200012)56:12<1098::aid-ps244>3.0.co;2-h

Cited by 42 publications

(5 citation statements)

References 5 publications

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“…Different stereoisomers of phomalactone ( F ) were isolated and reported previously from various sources [ 15 , 16 , 17 , 18 ], and some papers did not specify the absolute configuration [ 19 , 20 ], while others assigned the (5 R ,6 R ) absolute configuration to the large positive specific rotation [ 21 ], which was opposite to previous studies [ 15 , 16 , 17 , 18 , 22 ]. In order to determine the absolute configuration of phomalactone independently and unambiguously, we performed TDDFT-ECD, TDDFT-OR, and DFT-VCD studies, which consistently confirmed the (+)- cis -(5 S ,6 S ) absolute configuration (see Supplementary Materials ) [ 23 , 24 ].…”

Section: Resultsmentioning

confidence: 88%

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In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii

et al. 2022

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Toxoplasma gondii is an apicomplexan pathogen able to infect a wide range of warm-blooded animals, including humans, leading to toxoplasmosis. Current treatments for toxoplasmosis are associated with severe side-effects and a lack efficacy to eradicate chronic infection. Thus, there is an urgent need for developing novel, highly efficient agents against toxoplasmosis with low toxicity. For decades, natural products have been a useful source of novel bioactive compounds for the treatment of infectious pathogens. In the present study, we isolated eight natural products from the crude extract of the endophytic fungus Paraboeremia selaginellae obtained from the leaves of the plant Philodendron monstera. The natural products were tested for inhibiting Toxoplasma gondii proliferation, and their cytotoxicity was evaluated in different human cell lines. Six natural products showed antitoxoplasma activity with low or no cytotoxicity in human cell lines. Together, these findings indicate that biphenyl ethers, bioxanthracenes, and 5S,6S-phomalactone from P. selaginellae are potential candidates for novel anti-toxoplasma drugs.

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Section: Resultsmentioning

confidence: 88%

“…[ 16 ]. It has a wide range of activities such as antifungal, immunomodulating, insecticide, nematocidal, and phytotoxic activity [ 15 , 19 , 33 , 34 , 35 ]. In addition, it has been found to be active against the apicomplexan parasite P. falciparum, with an IC 50 of 84.32 µM [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii

et al. 2022

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“…Two compounds namely Phomalactone and Monorden from P. chlamydosporia have nematicidal activity and various biological activities. M. incognita control was less through Phomalactone in comparison with Aldicarb (Khambay et al, 2000). The new compounds which were present in the culture broth of P. chlamydosporia var.…”

Section: Secondary Metabolites Of P Chlamydosporiamentioning

confidence: 86%

Bionomics and the role of antinemic metabolites of the nematophagous fungus, Pochonia chlamydosporia in suppressing phytonematodes - A Comprehensive Review

et al. 2024

Preprint

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Pochonia chlamydosporia, a nematophagous fungus is well-known for its biocontrol potential against plant-parasitic nematodes. This review paper documented colonization patterns of P. chlamydosporia in soil, roots, and the rhizosphere, highlighting the impact of various abiotic factors on its establishment. The biocontrol efficacy of P. chlamydosporia against nematodes, including Meloidogyne spp., Globodera spp., and Heterodera spp., is extensively discussed, covering its mode of action and application methods. Additionally, the review delves into the enzyme secretion, endophytic nature, and secondary metabolites produced by P. chlamydosporia, shedding light on their roles in nematode control and plant growth promotion. P. chlamydosporia application triggers the activation of plant defence mechanisms is also elucidated, emphasizing its potential to induce a robust defence response in host plants. Overall, this comprehensive review consolidates the current knowledge on P. chlamydosporia, offering valuable insights for researchers, practitioners, and policymakers involved in sustainable nematode management strategies.

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“…The gene cluster for the synthesis of RALs compounds in P. chlamydosporia PC-170 has been identified. A total of 30 RALs compounds have been discovered in P. chlamydosporia ( Khambay et al, 2000 ; Hellwig et al, 2003 ; Shinonaga et al, 2009a , b ; Qin et al, 2019 ). RALs compounds have a range of biological activities, but less nematicidal activity has been reported.…”

Section: Discussionmentioning

confidence: 99%

Nematicidal glycosylated resorcylic acid lactones from the fungus Pochonia chlamydosporia PC-170 and their key biosynthetic genes

Li,

Luo,

Zhang

et al. 2024

Front. Microbiol.

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Chemical study of the nematicidal biocontrol fungus Pochonia chlamydosporia PC-170 led to discovery of six resorcylic acid lactones (RALs), including three nematicidal glycosylated RALs, monocillin VI glycoside (1), colletogloeolactone A (2) and monocillin II glycoside (3), and three antibacterial non-glycosylated RALs, monocillin VI (4), monocillin IV (5) and monocillin II (6). The planar structure of the new compound monocillin VI glycoside (1) was elucidated using HRESIMS and NMR data, and its monosaccharide configuration was further determined through sugar hydrolysis experiment and GC–MS analysis method. Furthermore, their two biosynthetic-related PKS genes, pchE and pchI, were identified through the gene knockout experiment. The glycosylated RALs 1–3 exhibited nematicidal activity against Meloidogyne incognita, with LC50 values of 94, 152 and 64 μg/mL, respectively, and thus had great potential in the development of new nematicidal natural products to control M. incognita in the future.

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A nematicidal metabolite fromVerticillium chlamydosporium

Cited by 42 publications

References 5 publications

In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii

In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii

Bionomics and the role of antinemic metabolites of the nematophagous fungus, Pochonia chlamydosporia in suppressing phytonematodes - A Comprehensive Review

Nematicidal glycosylated resorcylic acid lactones from the fungus Pochonia chlamydosporia PC-170 and their key biosynthetic genes

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